Hubungan Antara Status Kolesterol High Density Lipoprotein (HDL) Serum dan Tingkat Risiko Terjadinya Obstructive Sleep Apnea ( OSA ) pada Penduduk di Kecamatan Sekarbela Mataram.

  • Fatarosdiana Fatarosdiana Fakultas Kedokteran Universitas Mataram
  • Herpan Syafii Harahap Fakultas Kedokteran Universitas Mataram
  • Novrita Padauleng Fakultas Kedokteran Universitas Mataram

Abstract

Latar belakang: Obstructive sleep apnea (OSA) adalah salah satu faktor risiko penyakit kardiovaskular, dan sebelumnya dilaporkan berhubungan dengan status kolesterol HDL serum. Tujuan penelitian ini adalah untuk mengetahui korelasi antara status kolesterol HDL serum dan tingkat risiko OSA pada penduduk di Kecamatan Sekarbela Mataram.

Metode: Penelitian ini merupakan jenis penelitian deskriptif analitik dengan desain potong lintang. Penduduk berusia lebih dari 50 tahun di beberapa lingkungan Kelurahan Karang Pule dan Tanjung Karang, Kecamatan Sekarbela Mataram diikutsertakan dalam penelitian ini. Sebanyak 65 partisipan memenuhi kriteria inklusi. Tingkat risiko OSA diestimasi berdasarkan STOP-Bang questionnaire yang meliputi mendengkur, kelelahan pada siang hari, henti napas saat tidur, riwayat hipertensi, IMT, usia, lingkar leher, jenis kelamin. Pengukuran status kolesterol HDL serum juga dilakukan. Analisis data menggunakan uji korelasi Somers’d.

Hasil: Dari 65 partisipan, 43 (66%) memiliki tingkat risiko OSA yang tinggi. Sebanyak 30 (54%), 14 (21%) dan 16 (25%) partisipan dikategorikan status kolesterol HDL serum rendah, borderline dan optimal. Analisis korelasi Somers’d menunjukkan tidak ada korelasi antara status kolesterol HDL serum dengan tingkat risiko OSA (p > 0,05).

Kesimpulan: Tidak terdapat korelasi antara status kolesterol HDL serum dan tingkat risiko OSA di Sekarbela Mataram

References

1. Jean-Louis G, Zizi F, Brown D, Ogedegbe G, Borer JS, McFarlane SI. Obstructive sleep apnea and cardiovascular disease: evidence and underlying mechanisms. Minerva Pneumologica, 2009; 48(4),277–293. Available from:. [Accessed Sep 11, 2015].

2. Young T, Peppard P, Palta M, Dempsey J, Nieto FJ, Hla KM. Population-based study of sleep disordered breathing as a risk factor for hypertension. Arch Intern Med, 1997; 157:1746–52. Available from: [Accessed March 12, 2016].

3. Butt M, Dwivedi G, Khair O, Lip GY. Obstructive sleep apnea and cardiovascular disease. International Journal of Cardiology, 2010; 139(1), pp.7–16. Available from: [Accessed Apr 24, 2016].

4. Chung F, Chung SA, Islam S, Liao P, Vairavanathan S, Yegneswaran B et al. STOP Questionnaire. the American Society of Anesthesiologists, 2008; 108(5), pp.812–821. Available from: [Accessed 22 Des 22, 2015].

5. Chung F. Screening for Obstructive Sleep Apnea Syndrome in the Preoperative Patients. The Open Anesthesiology Journal, 2011; 5, pp.7–11. Available from: [Accessed Des 22, 2015].

6. Borgel J, Sanner BM, Bittlinsky A, Keskin F, Bartels NK, Buechner N et al. Obstructive sleep apnoea and its therapy influence high-density lipoprotein cholesterol serum levels. Eur Respir J, 2006; 27(1), pp.121–127. Available from: [Accessed Aug 7, 2016].

7. Mabry JE, Herbert WG, Myers JN, Hosig KW, Hanowski RJ, Zedalis D et al. Obstructive Sleep Apnea Risk in Abdominal Aortic Aneurysm Disease Patients: Associations with Physical Activity Status, Metabolic Syndrome, and Exercise Tolerance. 2013. Available from: [Accessed Aug 7, 2016].

8. Sastroasmoro S, dan Ismael S. Studi cross-sectional. In: Ghazali, M.V., Sastromihardjo, S., Soedjarwo, S.R. ,Soelaryo, T., Pramulyo, H.S., ed. Dasar-dasar Metodologi Penelitian Klinis. 4th ed. Jakarta : Sagung Seto, 2011, p.130-131.

9. Dahlan MS. Besar Sampel dan Cara Pengambilan Sampel dalam Penelitian Kedokteran dan Kesehatan. Edisi 3. Jakarta: Salemba Medika, 2013.

10. Jellinger PS, Smith DA, Mehta AE, Ganda O, Handelsman Y, Rodbard HW et al. Guidelines for Management of Dyslipidemia and Prevention of Atherosclerosis. AACE Guidelines, 2012; 18(1), p.1-58. Available from: [Accessed Jul 29 2016].

11. Dahlan MS. Statistik Untuk Kedokteran dan Kesehatan. Edisi 5. Jakarta: Salemba Medika, 2013.

12. Javadi HR, Jalilolghadr S, Yazdi Z, Majd ZR et al. Correlation between Obstructive Sleep Apnea Syndrome and Cardiac Disease Severity. Cardiovascular Psychiatry and Neurology, 2014, pp.1–5. Available from: [Accessed Aug 18, 2016].

13. Zamarron C, Cuadrado LV, dan Sala RA. Pathophysiologic Mechanisms of Cardiovascular Disease in Obstructive Sleep Apnea. Sleep Medicine Clinics, 2013; 2(4), pp.539–547. Available from: [Accessed Des 22, 2015].

14. Kim HJ, Park HA, Cho YG, Kang JH, Kim KW, Kang JH et al. Gender Difference in the Level of HDL Cholesterol in Korean Adults. Korean J Fam Med, 2011; 32(3), pp.173–181. Available from: [Accessed Aug 18, 2016].

15. Quintana-gallego E, Anchez-Armengol A, Botebol-Benhamou G,Carmona-Bernal C, Capote F, Padillo JP et al. Gender differences in obstructive sleep apnea syndrome : a clinical study of 1166 patients, 2004, pp.984–989. Available from: [Accessed Aug 16, 2016].

16. Bixler EO, Have TT, Lin HM, Rein J, Vela-Bueno A, Vgontzas AN et al. Prevalence of Sleep-disordered Breathing in Women Effects of Gender. Am J Respir Crit Care Med, 2001; 163, pp.608–613. Available from:[ Accessed Aug 16, 2016].

17. Romero-Corral A, Caples SM, Jimenez L, Somers VK. Interactions between obesity and obstructive sleep apnea: Implications for treatment. Chest, 2010; 137(3), pp.711–719. Available from: [Accessed Jun 24, 2016].

18. Fawale MB, Ibigbami O, Ismail I, Mustapha AF, Komolafea MA, Olamayegun MA et al. Risk of obstructive sleep apnea , excessive daytime sleepiness and depressive symptoms in a Nigerian elderly population. Sleep Science, 2016; pp.1–6. Available from: [Accessed Aug 8, 2016].

19. Schellenberg JB, Maislin G, & Schwab RJ. Physical Findings and the Risk for Obstructive Sleep Apnea The Importance of Oropharyngeal Structures, 2000. Available from: [Accessed Aug 8, 2016].

20. Ansari A, Al-Saey H, Al-Sulaiti M, S Ganesan, Sattar AH, P Balamurugam et al. Original Body Mass Index ( BMI ) and Neck Circumference ( NC ) in Diagnosing Obstructive Sleep Apnea. Qatar Medical Journal, 2007; 16(1), pp.45–47. Available from: [Accessed Aug 8, 2016].

21. Medeiros CAM, Bruin VMS, Castro-Silva C, Araujo SMH, Junior CMC, Bruin PFC. Neck circumference , a bedside clinical feature related to mortality of acute ischemic stroke. Rev Assoc Med Bras, 2011; 57(5), pp.547–552. Available from: [ Accessed Aug 8, 2016].

22. Carr MC. The Emergence of the Metabolic Syndrome with Menopause. The Journal of Clinical Endocrinology & Metabolism, 2016; 88(8), pp.2404–2411. Available from: [Accessed Aug 18 2016].

23. Polotsky HN & Polotsky AJ. Metabolic implications of menopause. Semin. Reprod. Med, 2010; 28, 426–434. Available from: [Accessed Aug 18, 2016].

24. Anagnostis P, Stevenson JC, Crook D, Johnston DG, Godsland IF. Effects of menopause, gender age on lipids and high-density lipoprotein cholesterol subfractions. Maturitas, 2015; 81: 62–68. Available from: [Accessed Aug 18 2016].

25. Fernandez ML & Murillo AG. Postmenopausal Women Have Higher HDL and Decreased Incidence of Low HDL than Premenopausal Women with Metabolic Syndrome. Healthcare, 2016; 4(20), pp.1–10. Available from: [Accessed Aug 18 2016].
Published
2017-11-28
Section
Research