Beberapa Khasiat Buah Tin (Ficus Carica) Dari Antikonvulsan, Anti Alergik, Anti Inflamasi, Antihiperglikemik, Antitumor, Anti Kanker Hingga Terapi Hati

  • fadhilah nur azizah ruslan universitas muslim indonesia
  • Armanto Makmun


Buah tin  (Ficus carica) adalah sumber zat besi, kalsium, fosfor, dan serat. Buah tin telah digunakan di seluruh dunia untuk mengobati berbagai gangguan kesehatan. Ficus carica Berasal dari Timur Tengah dan Asia Barat, tetapi menyebar ke banyak wilayah lain di dunia. Produk dari Ficus carica banyak digunakan sebagai sumber makanan dan obat-obatan untuk mengobati berbagai penyakit. Berdasarkan uraian yang disebutkan, maka peneliti tertarik untuk mengkaji lebih lanjut mengenai manfaat yang terkandung dalam Buah tin. 


1. Butu M, Rodino S. Fruit and Vegetable-Based Beverages—Nutritional Properties and Health Benefits [Internet]. Natural Beverages. Elsevier Inc.; 2019. 303–338 p. Available from:
2. Choubane S, Cheba BA, Benourrad A. Screening and Phenotypic Diversity of Amylase Producing Rhizospheric Bacteria from Some North African Plants. Procedia Technol. 2016;22:1197–204.
3. Fernandez-Flores A, Llamas Velasco M, Saeb Lima M. Guarumbo (Cecropia obtusifolia) for Warts in Zapotec Medicine. Actas Dermosifiliogr [Internet]. 2020;111(3):189–91. Available from:
4. Alzahrani HR, Kumakli H, Ampiah E, Mehari T, Thornton AJ, Babyak CM, et al. Determination of macro, essential trace elements, toxic heavy metal concentrations, crude oil extracts and ash composition from Saudi Arabian fruits and vegetables having medicinal values. Arab J Chem [Internet]. 2017;10(7):906–13. Available from:
5. Chai L, Chai P, Chen S, Flaishman MA, Ma H. Transcriptome analysis unravels spatiotemporal modulation of phytohormone-pathway expression underlying gibberellin-induced parthenocarpic fruit set in San Pedro-type fig (Ficus carica L.). BMC Plant Biol. 2018;18(1):1–15.
6. Sharma SH, Kumar JS, Chellappan DR, Nagarajan S. Molecular chemoprevention by morin – A plant flavonoid that targets nuclear factor kappa B in experimental colon cancer. Biomed Pharmacother [Internet]. 2018;100(December 2017):367–73. Available from:
7. Mashile SP, Tshisikhawe MP, Masevhe NA. Indigenous fruit plants species of the Mapulana of Ehlanzeni district in Mpumalanga province, South Africa. South African J Bot [Internet]. 2019;122:180–3. Available from:
8. Nirwana I, Rianti D, Helal Soekartono R, Listyorini RD, Basuki DP. Antibacterial activity of fig leaf (Ficus carica Linn.) extract against Enterococcus faecalis and its cytotoxicity effects on fibroblast cells. Vet World. 2018;11(3):342–7.
9. Ling WT, Liew FC, Lim WY, Subramaniam S, Chew BL. Shoot induction from axillary shoot tip explants of fig (Ficus carica) cv. japanese BTM 6. Trop Life Sci Res. 2018;29(2):165–74.
10. Zhang Y, Wan Y, Huo B, Li B, Jin Y, Hu X. Extracts and components of ficus carica leaves suppress survival, cell cycle, and migration of triple-negative breast cancer MDA-MB-231 cells. Onco Targets Ther. 2018;11:4377–86.
11. Pathania D, Sharma S, Singh P. Removal of methylene blue by adsorption onto activated carbon developed from Ficus carica bast. Arab J Chem [Internet]. 2017;10:S1445–51. Available from:
12. Shivaprasad H V., Rajaiah R, Frey BM, Frey FJ, Vishwanath BS. “Pergularain e I” - a plant cysteine protease with thrombin-like activity from Pergularia extensa latex. Thromb Res [Internet]. 2010;125(3):e100–5. Available from:
13. Sheikh BY, Sarker MMR, Kamarudin MNA, Ismail A. Prophetic medicine as potential functional food elements in the intervention of cancer: A review. Biomed Pharmacother [Internet]. 2017;95(2017):614–48. Available from:
14. Comparin BC, Santos CHM dos, Dourado DM, Reichel PMG, Paola RS de, Pontes ERJC. Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extract. J Coloproctology [Internet]. 2018;38(4):283–9. Available from:
15. Aldhebiani AY, Elbeshehy EKF, Baeshen AA, Elbeaino T. Inhibitory activity of different medicinal extracts from Thuja leaves, ginger roots, Harmal seeds and turmeric rhizomes against Fig leaf mottle-associated virus 1 (FLMaV-1) infecting figs in Mecca region. Saudi J Biol Sci [Internet]. 2017;24(4):936–44. Available from:
16. Veselská T, Kola?ík M. Fungal metabolic profile dataset was not influenced by long-term in vitro preservation of strains. Data Br. 2019;27.
18. Mijit M, HE Z, HONG J, LU M guang, LI S fang, ZHANG Z xiang. Analysis of fig tree virus type and distribution in China. J Integr Agric [Internet]. 2017;16(6):1417–21. Available from:
19. Raafat K, Wurglics M. Phytochemical analysis of Ficus carica L. active compounds possessing anticonvulsant activity. J Tradit Complement Med [Internet]. 2019;9(4):263–70. Available from:
20. Yeganehzad S, Kiumarsi M, Nadali N, Rabie Ashkezary M. Formulation, development and characterization of a novel functional fruit snack based on fig (Ficus carica L.) coated with sugar-free chocolate. Heliyon [Internet]. 2020;6(7):e04350. Available from:
21. Lu X, Wo G, Li B, Xu C, Wu J, Jiang C, et al. The anti-inflammatory NHE-06 restores antitumor immunity by targeting NF-?B/IL-6/STAT3 signaling in hepatocellular carcinoma. Biomed Pharmacother [Internet]. 2018;102(December 2017):420–7. Available from:
22. Turan A, Celik I. Antioxidant and hepatoprotective properties of dried fig against oxidative stress and hepatotoxicity in rats. Int J Biol Macromol [Internet]. 2016;91:554–9. Available from:
23. Zhang Y, Li Y, Ma P, Chen J, Xie W. Ficus carica leaves extract inhibited pancreatic ?-cell apoptosis by inhibiting AMPK/JNK/caspase-3 signaling pathway and antioxidation. Biomed Pharmacother [Internet]. 2020;122(November 2019):109689. Available from:
24. Abbasi S, Kamalinejad M, Babaie D, Shams SM, Sadr Z, Gheysari M, et al. A new topical treatment of atopic dermatitis in pediatric patients based on Ficus carica L. (Fig): A randomized, placebo-controlled clinical trial. Complement Ther Med [Internet]. 2017;35(August 2017):85–91. Available from:
25. Hedayat KM, Lapraz J-C. A general Endobiogenic approach to regulation of the immune system. The Theory of Endobiogeny. 2019;49–61.
26. Essid A, Aljane F, Ferchichi A. Morphological characterization and pollen evaluation of some Tunisian ex situ planted caprifig (Ficus carica L.) ecotypes. South African J Bot [Internet]. 2017;111:134–43. Available from:
27. Hamed MB, El-Badry MO, Kandil EI, Borai IH, Fahmy AS. A contradictory action of procoagulant ficin by a fibrinolytic serine protease from Egyptian Ficus carica latex. Biotechnol Reports [Internet]. 2020;27:e00492. Available from:
28. Hald MM, Magnussen B, Appel L, Christensen JT, Hansen CH, Henriksen PS, et al. Fragments of meals in eastern Denmark from the Viking Age to the Renaissance: New evidence from organic remains in latrines. J Archaeol Sci Reports [Internet]. 2020;31(April):102361. Available from:
29. Ayoub L, Hassan F, Hamid S, Abdelhamid Z, Souad A. Phytochemical screening, antioxidant activity and inhibitory potential of Ficus carica and Olea europaea leaves. Bioinformation. 2019;15(3):226–32.
30. Bayoudh C, Elair M, Labidi R, Majdoub A, Mahfoudhi N, Mars M. Efficacy of tissue culture in virus elimination from caprifig and female fig varieties (Ficus carica L.). Plant Pathol J. 2017;33(3):288–95.
31. Mopuri R, Ganjayi M, Meriga B, Koorbanally NA, Islam MS. The effects of Ficus carica on the activity of enzymes related to metabolic syndrome. J Food Drug Anal [Internet]. 2018;26(1):201–10. Available from:
32. Mahjour M, Khoushabi A, Miri Ghale Novi M, Feyzabadi Z. Food strategies of renal atrophy based on Avicenna and conventional medicine. J Tradit Complement Med [Internet]. 2017;7(4):375–9. Available from:
33. Ergül M, Ergül M, Eruygur N, Ata? M, Uçar E. In vitro evaluation of the chemical composition and various biological activities of ficus carica leaf extracts. Turkish J Pharm Sci. 2019;16(4):401–9.
35. Lazreg-Aref H, Gaaliche B, Ladhari A, Hammami M, Hammami SO. Co-evolution of enzyme activities and latex in fig (Ficus carica L.) during fruit maturity process. South African J Bot [Internet]. 2018;115:143–52. Available from:
36. Gaaliche B, Ladhari A, de Medeiros AG, Ben Mimoun M, Hajlaoui MR. Relationship between phytochemical profiles and phytotoxic proprieties of Tunisian fig leaf cultivars. South African J Bot [Internet]. 2017;112:322–8. Available from:
37. Allegra A, Gallotta A, Carimi F, Mercati F, Inglese P, Martinelli F. Metabolic profiling and post-harvest behavior of “dottato” fig (Ficus carica L.) fruit covered with an edible coating from O. ficus-indica. Front Plant Sci. 2018;9(September):1–10.
38. Ahmed S, Hasan MM, Khan H, Mahmood ZA, Patel S. The mechanistic insight of polyphenols in calcium oxalate urolithiasis mitigation. Biomed Pharmacother [Internet]. 2018;106(July 2018):1292–9. Available from:
39. Mori K, Shirasawa K, Nogata H, Hirata C, Tashiro K, Habu T, et al. Corrigendum: Identification of RAN1 orthologue associated with sex determination through whole genome sequencing analysis in fig (Ficus carica L.) (Scientific Reports, (2017), 7, 1, (41124), 10.1038/srep41124). Sci Rep. 2017;7(1):1–3.
40. Nadeem M, Zeb A. Impact of maturity on phenolic composition and antioxidant activity of medicinally important leaves of Ficus carica L. Physiol Mol Biol Plants [Internet]. 2018;24(5):881–7. Available from:
41. Naghdi M, Maghbool M, Seifalah-Zade M, Mahaldashtian M, Makoolati Z, Kouhpayeh SA, et al. Effects of common fig (Ficus carica) leaf extracts on sperm parameters and testis of mice intoxicated with formaldehyde. Evidence-based Complement Altern Med. 2016;2016:18–20.
42. Agustina E. Uji Aktivitas Senyawa Antioksidan Dari Ekstrak Daun Tiin (Ficus carica Linn) dengan Pelarut Air, Metanol dan Campuran Metanol-Air. Klorofil. 2017;1(1):38–47.
43. Janghel V, Patel P, Chandel SS. Plants used for the treatment of icterus (jaundice) in Central India: A review. Ann Hepatol [Internet]. 2019;18(5):658–72. Available from:
44. Bouyahya A, Abrini J, Et-Touys A, Bakri Y, Dakka N. Indigenous knowledge of the use of medicinal plants in the North-West of Morocco and their biological activities. Eur J Integr Med [Internet]. 2017;13(March 2017):9–25. Available from:
45. Mlinari? S, Antunovi? Duni? J, Štolfa I, Cesar V, Lepeduš H. High irradiation and increased temperature induce different strategies for competent photosynthesis in young and mature fig leaves. South African J Bot. 2016;103:25–31.
46. Taghizadeh M, Maghaminejad F, Aghajani M, Rahmani M, mahboubi M. The effect of tablet containing Boswellia serrata and Melisa officinalis extract on older adults’ memory: A randomized controlled trial. Arch Gerontol Geriatr. 2018;75(December 2017):146–50.
47. Mahmoudi S, Khali M, Benkhaled A, Benamirouche K, Baiti I. Phenolic and flavonoid contents, antioxidant and antimicrobial activities of leaf extracts from ten Algerian Ficus carica L. varieties. Asian Pac J Trop Biomed [Internet]. 2016;6(3):239–45. Available from:
48. Mopuri R, Islam MS. Antidiabetic and anti-obesity activity of Ficus carica: In vitro experimental studies. Diabetes Metab [Internet]. 2016;42(4):300. Available from:
49. Zhang Y, Chen J, Zeng Y, Huang D, Xu Q. Involvement of AMPK activation in the inhibition of hepatic gluconeogenesis by Ficus carica leaf extract in diabetic mice and HepG2 cells. Biomed Pharmacother [Internet]. 2019;109(October 2018):188–94. Available from:
50. Solorzano Zambrano L, Usai G, Vangelisti A, Mascagni F, Giordani T, Bernardi R, et al. Cultivar-specific transcriptome prediction and annotation in Ficus carica L. Genomics Data [Internet]. 2017;13(July):64–6. Available from: