Immune Response to Sports

  • Ida Ayu Eka Widiastuti universitas Mataram


The physiological function of the immune system is to defend against infectious microbes; even non-infectious foreign substances and damaged cell products that can elicit an immune response. The response from exercise, both acute and chronic, will have an effect on the components of the immune system. The immune response that occurs depends on the intensity and duration of exercise. Moderate intensity exercise will stimulate various parameters related to cellular immunity so that it can reduce the risk of infection, while high intensity exercise will result in a reduction in the same parameters, which will increase the risk of infectious diseases. The response from exercise or doing regular physical activity can affect immune cells, such as: neutrophils, antigen precenting cells (APC), natural killer cells (NK cells), and lymphocytes as well as  cytokine production.


1. Terra R, Gonzalves da Silva SA, Pinto, VS, Dutra PML. Effect of exercise on the immune system: response, adaptation and cell signaling. Rev Bras Med Esporte 2012;18(3):208-214.
2. Plowman SA, Smith DL. Exercise physiology for health, fitness, and performance. Baltimore: Lippincott Williams and Wilkins;2008
3. Nielsen HG. Exercise and immunity. In Tech: Current Issues in Sports and Exercise Medicine. Tersedia di cdn. and immunity.pdf.
4. Sudiono J. Sistem kekebalan tubuh. Jakarta: Penerbit Buku Kedokteran EGC;2014
5. Abbas AK, Lichtman AH, Pillai S. Cellular and molecular immunology. Philadelphia: Elsevier;2018
6. Wahid S, Miskad UA. Imunologi: lebih mudah dipahami. Surabaya: Brilian Internasional;2016.
7. Gavriele, Ashlagi-Amiri RT, Eliakim A, Nemet D, Zigel L, Berger-Achituv S, et al. The Effect of Aerobic Exercise on Neutrophil Functions. Med Sci Sports Exerc 2008;40:1623-8.
8. Butterfield TA, Best TM, Merrick MA. The Dual Roles of Neutrophils and Macrophages in Inflammation: A Critical Balance Between Tissue Damage and Repair. J Athle Training 2006;41:457-465.
9. Brickson S, Hollander J, Corr DT, Ji LL, Best TM. Oxidant production and immune response after stretch injury in skeletal muscle. Med Sci Sports Exerc 2001;33:2010-5.
10. Wolach B, Falk B, Gavrieli R, Kodesh E, Eliakim A. Neutrophil function response to aerobic and anaerobic exercise in female judoka and untrained subjects. Br J Sports Med 2000;34:23-7.
11. Suzuki K. Exhaustive exercise-induced neutrophil-associated tissue damage and possibility of its prevention. Journal of Nanomedicine & Biotherapeutic Discovery 2017;7(2)
12. Walsh, N. Effect of oral glutamine supplementation on human neutrophil lipopolysaccharide-stimulated degranulation following prolonged exercise. Int J Sport Nutr Exerc Metab 2000 ;10 :39-50.
13. Gleeson M, McFarlin B, Flynn, M. Exercise and Toll-like receptors. Exerc Immunol Rev 2006;12:34-5.
14. Kizaki T, Takemasa T, Sakurai T, Izawa T, Hanawa T, Kamiya T, et al. Adaptation of macrophages to exercise training improves innate immunity. Biochem Biophys Res Communic 2008;372:152-6.
15. Jost J, Weiss M, Weicker R. Sympathoadrenergic regulation and the adrenoceptor system. J Appl Physiol 1990;68:897-904.
16. Chiang LM, Chen YJ, Chiang J, Lai LY, Chen YY, Liao HF. Modulation of Dendritic Cells by Endurance Training. Int J Sports Med 2007;28:798-803.
17. Malm C, Sjodin TL, Sjoberg B, Lenkei R, Renstrom P, Lundberg IE, et al. Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill running. J Physiol 2004;556:983-1000.
18. Navalta, JW, Sedlock DA, Park KS. Effect of Exercise Intensity on Exercise-Induced Lymphocyte Apoptosis. Int J Sports Med 2007;28:539-42.
19. Pedersen BK, Febbraio MA. Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6. Physiol Rev 2008;88:1379-406.
20. Toft AD, Jensen LB, Bruunsgaard H, Ibfelt T, Halkjaer-Kristensen J, Febbraio M, et al. Cytokine response to eccentric exercise in young and elderly humans. Am J Physiol 2002;283:C289-95.