HBA1C SEBAGAI KANDIDAT BIOMARKER UNTUK PREDIKSI PROGESIVITAS GANGGUAN KOGNITIF TERKAIT DIABETES MELITUS TIPE 2

  • Putri Nurhayati Fakultas Kedokteran Universitas Mataram
  • Achmad Mujahidin Irham Universitas Mataram
  • I Dewa Bagus Ketut Widya Pramana Fakultas Kedokteran Universitas Mataram
  • Herpan Syafii Harahap Fakultas Kedokteran Universitas Mataram
Keywords: Type 2 diabetes mellitus, insulin resistance, hyperglycemia, cognitive impairment, HbA1c

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia which underlie its complications, including cognitive impairment. T2dm-associated cognitive impairment is generally characterized by the decrease in at least one cognitive domain. However, its progression can be slowed by appropriate blood glucose control. Hb1Ac is a candidate of appropriate biomarker in predicting the progression of T2DM-associated cognitive impairment. This is based on several important characteristics it has, including a good blood glucose index, low daily biological variability, relatively unaffected by stress conditions, and unaffected by variations due to loading the amount of glucose.

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Published
2022-03-30
Section
Literature Review