Gut-Brain Connection : The Role Of Gut Microbiome in Preventing Stroke

  • Baiq Annisa Pratiwi Universitas Mataram
  • Putu Diah Ananda Putri Atmaja Universitas Mataram
  • Qurrata’yuni Pratiwi Mataram University
  • Ilsa Hunaifi Universitas Mataram
Keywords: Gut-Brain Connection, Gut-Brain Axis, Microbiome, Stroke

Abstract

Stroke is the second most prevalent cause of death in the world and placed third in disability causes worldwide. Beside affecting health, the reduced quality of life and the expensive cost of its treatment also has a huge impact on social, physical, and psychological aspect of a patient. Currently, the management of stroke is centered on currative and rehabilitative effort. Hence, the preventive efforts are on demand. Several studies have showed that there is a link between gut microbiota and the nervous system in somehing called the Gut-Brain Axis (GBA). Intestinal microbiota plays an important role in GBA. Therefore, maintaining the balance of intestinal microbiota, through neuronal or non-neuronal two-way communication between both of those system, is a promising way to prevent stroke.

References

[1] N. Venketasubramanian, B. W. Yoon, J. Pandian and a. J. C. Navarro, "Stroke Epidemiology in South, East, and South-East," Journal of stroke, vol. 19, no. 3, pp. 286-294, (2017).
[2] W. Johnson, O. Onuma, M. Owolabi and S. Sachdev, "Stroke: a global response is needed," Bulletin of the World Health Organization, vol. 94, no. 9, pp. 633-708, 2016.
[3] Y. Turana, K. Kario and e. al, "Hypertension and stroke in Asia: A comprehensive review from HOPE Asia," The Journal of Clinical Hypertension, vol. 23, no. 3, pp. 513-521, 2020.
[4] Kementrian Kesehatan RI, "Pusdatin Kemenkes," 28 Oktober 2019. [Online]. Available: https://pusdatin.kemkes.go.id/download.php?file=download/pusdatin/infodatin/infodatin-stroke-dont-be-the-one.pdf. [Accessed 12 April 2021].
[5] A. K. Hasan, "STUDY KASUS GANGGUAN PERFUSI JARINGAN SEREBRAL DENGAN PENURUNAN KESADARAN PADA KLIEN STROKE HEMORAGIK SETELAH DIBERIKAN POSISI KEPALA ELEVASI 30º," Jurnal Ilmiah Multi Science Kesehatan Volume 9 NO 2, 2018.
[6] V. M. Adams RD, The Neurology of Aging. In Adams and Victor’s Principle Of Neurology, 9th Edition, USA:The McGraw: Hill Companies, 2009.
[7] A. K. Wijaya, "Patofisiologi Stroke Non-Hemoragik Akibat Trombus," Bagian SMF Ilmu Penyakit Saraf Fakultas Kedokteran universitas Udayana, 2013.
[8] T. d. W. Aninditha, Buku Ajar Neurologi, Jakarta: Departemen Neurologi FKUI, 2017.
[9] M. Carabotti, A. Scirocco, M. A. Maselli and C. Severi, "The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems," Ann Gastroenterol, 2015.
[10] M. Carabotti, A. Scirocco, M. A. Maselli and C. Severia, "The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems," Annals of Gastroenterology, vol. 28, no. 2, pp. 203-209, 2015.
[11] J. Appleton, "The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health," IMCJ, vol. 17, no. 2, pp. 28-32, 2018.
[12] P. David J. Durgan, P. Juneyoung Lee, M. P. Louise D. McCullough and P. Robert M. Bryan Jr, "Examining the Role of the Microbiota-Gut-Brain Axis in Stroke," ahajournals, vol. 50, no. 8, pp. 2270-2277, 2019.
[13] J. Appleton, "The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health," Integrative Medicine : a Clinician's Journal, vol. 17, no. 4, pp. 28-32, 2018.
[14] C. R. Martin, V. Osadchiy, A. Kalani and E. A. Mayer, "The Brain-Gut-Microbiome Axis," CMGH, vol. 6, no. 2, pp. 133-148, 2018.
[15] C. R. Martin, V. Osadchiy, A. Kalani and a. E. A. Mayer, "The Brain-Gut-Microbiome Axis," Cellular and Molecular Gastroenterohepatology, vol. 6, no. 2, pp. 133-148, 2018.
[16] Y. K. K. a. C. Shin, "The Microbiota-Gut-Brain Axis in Neuropsychiatric Disorders: Patho-physiological Mechanisms and Novel Treatments," Current Neuropharmacology, vol. 16, no. 5, pp. 559-573, 2018.
[17] B. Y. Q. Tan, P. R. Paliwal and a. V. K. Sharma, "Gut Microbiota and Stroke," Annals of Indian Academy of Neurology, vol. 23, no. 2, pp. 155-158, 2020.
[18] V. Singh, S. Roth, G. Llovera, R. Sadler, D. Garzetti, B. Stecher, M. Dichgans and a. A. Liesz, "Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke," The Journal of Neuroscience, vol. 36, no. 28, pp. 7428-7440, 2016.
[19] A. K. Arya and B. Hu, "Brain–gut axis after stroke," Brain Circulation, vol. 4, no. 4, pp. 165-173, 2018.
[20] C. Benakis, D. Brea, S. Caballero, G. Faraco, J. Moore, M. Murphy, G. Sita, G. Racchumi, L. Ling, E. G. Pamer, C. Iadecola and a. J. Anrather, "Commensal microbiota affects ischemic stroke outcome by regulating intestinal ??T cells," Nature Med, vol. 22, no. 5, pp. 516-523, 2016.
Published
2022-03-30
Section
Literature Review