Laryngopharyngeal Reflux Disease

  • Ni Made Puspasari Mahadewi - Universitas Mataram
Keywords: Laryngopharingeal reflux, GERD, laryngitis, review


Laryngopharyngeal reflux (LPR) is a variation of gastric fluid reflux disorder that flows retrogradely to the extra-oesophageal laryngopharyngeal segment. LPR does not have typical symptoms and the symptoms shown vary widely, so it is often confused with other laryngeal symptoms. There are several risk factors that are considered to increase the possibility of LPR such as an unhealthy lifestyle, type of food and a history of certain comorbid diseases such as type 2 diabetes mellitus and hypertension. Although it is difficult to diagnose, this disease is quite often complained of, especially in patients who come to the ENT clinic, which is 10%. In addition, this disease can also increase the risk of other secondary diseases, including diseases of the lower respiratory tract, malignancy, and posterior laryngitis. As the management of LPR cases, in addition to pharmacological therapy, it is very important to pay attention to the lifestyle and types of food consumed.

Keywords: Laryngopharyngeal reflux, GERD, laryngitis, review


1. Toros, A.B. Laryngopharyngeal reflux. 2013. Journal of Medical Updates. 3(3):150–153.
2. Nartey, A. 2017. The Pathophysiology of Cataract and Major Interventions to Retarding Its Progression: A Mini Review. Advances in Ophthalmology & Visual System. 6(3):76–78.
3. Campagnolo, A.M., Priston, J., Thoen, R.H., Medeiros, T., dan Assunção, A.R. 2014. Laryngopharyngeal reflux: Diagnosis, treatment, and latest research. 18(2):184-191.
4. Massawe, W.A., Nkya, A., Abraham, Z.S., Babu, K.M., Moshi, N., Kahinga, A.A., Ntunaguzi, D. dan Massawe, E.R. 2021.Laryngopharyngeal reflux disease, prevalence and clinical characteristics in ENT department of a tertiary hospital Tanzania. World Journal of Otorhinolaryngology - Head and Neck Surgery. 7(1):28–33.
5. Lechien, J.R., Saussez, S., Muls, V., Barillari, M.R., Chiesa-Estomba, C.M., Hans, S., dan Karkos, P.D. 2020. Laryngopharyngeal reflux: A state-of-the-art algorithm management for primary care physicians. Journal of Clinical Medicine. 9(11):3618.
6. Da Silva, C.E.D., Niedermeier, B.T., dan Portinho, F. 2014. Reflux laryngitis: Correlation between the symptoms findings and indirect laryngoscopy. International Archives of Otorhinolaryngology. 19(3):234–237.
7. Wood, J.M., Athanasiadis, T., dan Allen, J. 2014. Laryngitis. BMJ. 349.
8. Brown, S. 2019. Otorhinology Head and Neck Surgery. Edisi ke-8. Vol. 3.
9. Megwalu, U.C. 2013. A systematic review of proton-pump inhibitor therapy for laryngopharyngeal. Ear Nose Throat Journal. 92(8):364-371.
10. Liu, C., Wang, H., dan Liu, K. 2016. Meta-analysis of the efficacy of proton pump inhibitors for the symptoms of laryngopharyngeal reflux. Brazilian Journal of Medical and Biological Research. 47(7):1-5.
11. Wilsono, J.A., Stockeno, D.D., Watsono, G.C., Fouweathero, T., McGlashano, J., MacKenzieo, K., Carding, P., dkk. 2021. Lansoprazole for persistent throat symptoms in secondary care: The TOPPITS RCT. Health Technology Assessment. 25(3):1–118.
12. Spantideas, N., Drosou, E., Bougea, A., dan AlAbdulwahed, R. 2020. Proton Pump Inhibitors for the Treatment of Laryngopharyngeal Reflux. A Systematic Review. Elsevier. 34(6):918-929.
13. Kim, J.H., Sung, I.K., Hong, S.N., Lee, S.Y., Park, H.S., Shim, C.S. 2013. Is the proton pump inhibitor test helpful in patients with laryngeal symptoms? World Journal of Gastroenterology. 58(6):1663–1667.
14. Huestis, M.J., Keefe, K.R., Kahn, C.I., Tracy, L.F. dan Levi, J.R. 2020. Alternatives to Acid Suppression Treatment for Laryngopharyngeal Reflux. 129(10):1030-1039.
15. Pizzorni, N., Ambrogi, F., Eplite, A., Rama, S., Robotti, C., Lechien, J. dan Schindler, A. 2022. Magnesium alginate versus proton pump inhibitors for the treatment of laryngopharyngeal reflux: a non-inferiority randomized controlled trial. European Archives of Oto-Rhino-Laryngology. 279(5):2533–2542.
16. Glicksman, J.T., Mick, P.T., Fung, K., dan Carroll, T.L. 2014. Prokinetic agents and laryngopharyngeal reflux disease: Prokinetic agents and laryngopharyngeal reflux disease: a systematic review. The Laryngoscope. 124(10):2375–2379.
17. Yoon, Y.H., Park, K.W., Lee, S.H., Park, H.S., Chang, J.W. dan Koo, B.S. 2019. Efficacy of three proton-pump inhibitor therapeutic strategies on laryngopharyngeal reflux disease; a prospective randomized double-blind study. Clinical Otolaryngology. 44(4):612–618.
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