Formula Optimization and Evaluation of Soap Gel Preparations of Hibiscus Leaf Ethanol Extract

Authors

  • Raodatul Istiharoh Universitas Mataram
  • Wahida Hajrin
  • Nisa Isnaeni Hanifa

DOI:

https://doi.org/10.29303/jku.v11i3.752

Keywords:

Carbopol 940, Hibiscus leave, HPMC, Optimization, Soap

Abstract

ABSTRACT

 

Purpose: Soaps currently circulating in the market still use synthetic active substances such as triclosan and triclocarban which have side effects such as irritation of the skin. The development of gel soap preparations containing ethanol extract of hibiscus leaves as the active substance needs to be done. In order to obtain good physical properties in gel soap preparations, an additional gelling agent is needed. The purpose of this study was to determine the concentration of carbopol 940 and Hydroxy Propyl Methyl Cellulose (HPMC) in the optimum formula.

Method: The optimization of the formula was carried out using the simplex lattice design method. The response parameters measured in the evaluation of the soap gel were pH, spreadability, foam height, and foam stability.

Result: The optimization results obtained the optimum formula, which is a combination of 0.25% HPMC and 1.75% carbopol 940. The results of the evaluation of the optimum formula in the experiment obtained the value of pH, dispersion, foam height and foam stability, respectively 4.74; 6.5 cm; 8.5 cm; 88.22%. The preparation of the gel soap is green, has a leaf-like aroma with a homogeneous preparation and the viscosity is included in the non-Newton flow.

Conclusion: The optimum formula for hibiscus leaf extract gel soap can be made with a combination of 0.25% HPMC and 1.75% carbopol 940 in order to obtain a gel soap that meets the physical properties requirements of a good gel soap preparation.

References

1. Rosana A, Wijaya IGPS, Bimantoro F. Sistem pakar diagnosa penyakit kulit pada manusia dengan metode dempster shafer. J-Cosine. 2020;4(2):129-138.
2. Zulbayu LOMA, Juliansyah R, Firawati F. Optimasi konsentrasi sukrosa terhadap transparansi dan sifat fisik sabun padat transparan minyak atsiri sereh wangi (Cymbopogon citratus l.). J Mandala Pharmacon Indones. 2020;6(2):91-96. doi:10.35311/jmpi.v6i1.60
3. Tjay TH, Rahardja K. Obat-Obat Penting. 7th ed. PT Elex Media Komputindo; 2015.
4. Isnawati N. Formulation and Effectiveness Test of Eschericia coli Bacteria Organic Liquid Soap Preparations Aloe Vera Leaf ( Aloe Vera Linn ). Heal Media. 2020;1(2):45-49.
5. Tiwari U, Yadav P, Nigam D. Study on phytochemical screening and antibacterial potential of methanolic flower and leaf extracts of Hibiscus rosa sinensis. Int J Innov Arplied Res. 2015;3(6):9-14.
6. Nugraha PG. Daya antibakteri ekstak daun kembang sepatu (Hibiscus rosa-sinensis) terhadap pertumbuhan bakteri Staphylococcus aureus secara in vitro. Published online 2015.
7. Yamlean PVY, Lolo AW. Aktivitas antibakteri salep ekstrak daun kembang sepatu ( Hibiscus rosa sinensis L.) terhadap luka yang terinfeksi bakteri Staphylococcus aureus pada kelinci (Oryctolagus cuniculus). J Ilm Farm. 2016;5(4):298-304.
8. Adiwibowo MT, Herayati H, Erlangga K, Fitria DA. Pengaruh metode dan waktu ekstraksi terhadap kualitas dan kuantitas saponin dalam ekstrak belimbing wuluh untuk aplikasi detergen. J Integr Proses. 2020;9(2):44-50.
9. Lestari FA, Hajrin W, Hanifa NI. Optimasi formula krim ekstrak daun katuk (Sauropus Androgynus) variasi konsentrasi asam stearat, trietanolamin, dan gliserin. J Kefarmasian Indones. 2020;10(2):110-119. doi:10.22435/jki.v10i2.2496
10. Rahayu T, Fudholi A, Fitria A. Optimasi formulasi gel ekstrak daun tembakau (Nicotiana tabacum) dengan variasi kadar karbopol940 dan tea menggunakan metode simplex lattice design (SLD). J Ilm Farm. 2016;12(1):16-24. doi:10.20885/jif.vol12.iss1.art3
11. Saryanti D, Nugraheni D, Astuti NS, Pertiwi NI. Optimasi karbopol dan hpmc dalam formulasi gel antijerawat nanopartikel ekstrak daun sirih (Piper betle linn). J Ilm Manuntung. 2019;5(2):192-199.
12. Adjeng ANT, Hairah S, Herman S, et al. Skrining fitokimia dan evaluasi sediaan sabun cair ekstrak etanol 96% kulit buah salak pondoh (Salacca zalacca (Gaertn.) Voss.) sebagai antioksidan. Pharmauho J Farm Sains, dan Kesehat. 2020;5(2):3-6.
13. Sukasih E, Setyadjit S, Sunarmani S, Pertiwi SRR. Optimasi formula tepung pisang cavendish (musa cavendishii) instan dengan metode respon surface. J Penelit Pascapanen Pertan. 2019;15(1):1-11. doi:10.21082/jpasca.v15n1.2018.1-11
14. Nurmiah S, Syarief R, Sukarno S, Peranginangin R, Nurmata B. Aplikasi response surface methodology pada optimalisasi kondisi proses pengolahan alkali treated cottonii (ATC). J Pascapanen dan Bioteknol Kelaut dan Perikan. 2013;8(1):9-22. doi:10.15578/jpbkp.v8i1.49
15. Rosi DH, Mulyani D, Deni R. Formulasi sediaan sabun padat transparan minyak atsiri kulit jeruk (citrus sinensis) (L.) osbeck. J Farm Higea. 2021;13(2):124-130.
16. Rompis F, Yamlean PVY, Lolo WA. Formulasi dan uji efektivitas antioksidan sediaan masker peel-off ekstrak etanol daun sesewanua (Cleodendron Squamatum vahl.). Pharmacon. 2019;8(2):388-396. doi:10.35799/pha.8.2019.29305
17. Ansel HC, Nicholas GP, Allen L V. Pharmaceutical Dosage Forms and Drug Delivery Systems. 9th ed. Lippincott Williams; 2011.

Downloads

Published

2022-11-02

How to Cite

Istiharoh, R., Wahida Hajrin, & Nisa Isnaeni Hanifa. (2022). Formula Optimization and Evaluation of Soap Gel Preparations of Hibiscus Leaf Ethanol Extract. Jurnal Kedokteran, 11(3), 1073–1078. https://doi.org/10.29303/jku.v11i3.752

Issue

Section

Research