EFFECTIVENESS OF MEFENAMIC ACID COMPARED TO IBUPROPHEN L-ARGININE AS ANALGESIC THERAPY
DOI:
https://doi.org/10.29303/jku.v12i1.848Keywords:
Analgesic, Pain, Ibuprofen, Mefenamic Acid,Abstract
Background: Analgesics are drugs used to reduce or relieve pain or painkillers without losing consciousness. This medication is used to help relieve pain, consciously or unconsciously. Ibuprofen and Mefenamic Acid are the most commonly used NSAID groups and be efficacious as inflammatory and analgesic drugs. From several studies, NSAIDs are better at relieving pain compared to Paracetamol. The most popular NSAID is diclofenac, followed by Ibuprofen, mefenamic acid, and naproxen based on sales data and lists of essential drugs in several countries.
Aims: This research aims to find out the effectiveness of mefenamic acid compared to Ibuprofen L-arginine as an analgesic.
Methods: This research was Quasi-Experimental with a double-blind controlled trial design. Pain stimulus using pain latency with an assessment based on VAS for 3 hours of observation.
Results: The results of this research show that each drug group shows a significant time difference. The Ibuprofen L-Arginine group has an average value of 84.21 seconds, while the Mefenamic Acid group only has an average of 63.04 seconds. Data show that the 600 mg Ibuprofen L-arginine group compared with Mefenamic Acid has a mean difference of 21.17 seconds (p 0.0036).
Conclusion: This research concludes that there is a significant difference in the effectiveness of analgesia between the mefenamic acid and Ibuprofen L-arginine groups, where mefenamic acid has slower analgesia effectiveness than Ibuprofen L-arginine.
Keywords: Analgesic, Pain, Ibuprofen, Mefenamic Acid,
References
Cajaraville, J. P. (2021). Ibuprofen Arginate For Rapid-Onset Pain Relief In Daily Practice: A Review Of Its Use In Different Pain Conditions. In Journal Of Pain Research (Vol. 14, Pp. 117–126). Dove Medical Press Ltd. Https://Doi.Org/10.2147/Jpr.S280571
Darr, U., & Sussman, N. L. (2020). Drug-Induced Liver Injury In The Setting Of Analgesic Use. In Clinics In Liver Disease (Vol. 24, Issue 1, Pp. 121–129). W.B. Saunders. Https://Doi.Org/10.1016/J.Cld.2019.09.008
Ermawati, D. E., & Prilantari, H. U. (2019). Pengaruh Kombinasi Polimer Hidroksipropilmetilselulosa Dan Natrium Karboksimetilselulosa Terhadap Sifat Fisik Sediaan Matrix-Based Patch Ibuprofen. Jpscr?: Journal Of Pharmaceutical Science And Clinical Research, 4(2), 109. Https://Doi.Org/10.20961/Jpscr.V4i2.34525
Isnenia. (2020). Pharmaceutical Journal Of Indonesia Penggunaan Non-Steroid Antiinflamatory Drug Dan Potensi Interaksi Obatnya Pada Pasien Muskuloskeletal. Pharmaceutical Journal Of Indonesia, 6(1), 47–55.
Larasati, D., & Sulistiani, R. (2020). Kajian Efek Analgetik Dispersi Padat Ibuprofen-Peg 6000 Menggunakan Metode Writhing Test The Study Of Analgesic Effect Of Ibuprofen-Peg 6000 Solid Dispersion Using Writhing Test Method. Jurnal Kesehatan Madani Medika, 11(01), 35–43.
Musiam, S., & Alfian, R. (2017). Validasi Metode Spektrofotometri Uv Pada Analisis Penetapan Kadar Asam Mefenamat Dalam Sediaan Tablet Generik. In Jurnal Ilmiah Ibnu Sina (Vol. 2, Issue 1).
Ratnawulan, S., Dan, M., & Husni, P. (2017). Pemberian Pemahaman Mengenai Penggunaan Obat Analgesik Secara Rasional Pada Masyarakat Di Arjasari Kabupaten Bandung. Dharmakarya, 6(3), 193–195. Http://Samples.Jbpub.Com/
Rusnaeni. Sinaga, Desy Ilmawati. Lanuru, Fitria. Payungallo, Imelda Meriyanti. Ulfiani, I. I. (2016). Identifikasi Asam Mefenamat Dalam Jamu Rematik Yang Beredar Di Distrik Heram Kota Jayapura, Papua. Pharmacy, 13(01), 84–91.
Sádaba, B., Campanero, M. A., Muñoz-Juarez, M. J., Gil-Aldea, I., García-Quetglas, E., Esteras, A., & Azanza, J. R. (2006). A Comparative Study Of The Pharmacokinetics Of Ibuprofen Arginate Versus Dexibuprofen In Healthy Volunteers. European Journal Of Clinical Pharmacology, 62(10), 849–854. Https://Doi.Org/10.1007/S00228-006-0180-5
Srivastava, R., Mishra, M. K., Patel, A. K., Singh, A., & Kushwaha, K. (2019). An Insight Of Non-Steroidal Anti-Inflammatory Drug Mefenamic Acid: A Review. Gsc Biological And Pharmaceutical Sciences, 7(2), 052–059. Https://Doi.Org/10.30574/Gscbps.2019.7.2.0066
Wardoyo, A. V., & Zakiah Oktarlina, R. (2019). Literature Review Tingkat Pengetahuan Masyarakat Terhadap Obat Analgesik Pada Swamedikasi Untuk Mengatasi Nyeri Akut. Association Between The Level Of Public Knowledge Regarding Analgesic Drugs And Self-Medication In Acute Pain, 10(2), 156–160. Https://Doi.Org/10.35816/Jiskh.V10i2.138
