Efektifitas Tramadol 100mg Supp dibandingkan dengan Ketoprofen 100mg Supp untuk Mengurangi Nyeri Selama 24 Jam Pasca Operasi Seksio Sesaria dengan Menggunakan Vas Skor di Rumah Sakit Bhayangkara
DOI:
https://doi.org/10.29303/jku.v6i3.1.265Keywords:
Nyeri, Opioid, NSAID, VAS skor.Abstract
Latar Belakang: Rasa nyeri yang ditimbulkan pasca operasi seksio sesaria adalah nyeri ringan hingga sedang. Tramadol dan Ketoprofen merupakan obat yang dapat digunakan untuk mengurangi nyeri pasca operasi seksio sesaria. Tramadol berkerja dengan menghambat reseptor opioid dan ketoprofen berkerja dengan penghambatan jalur siklooksigenase dari metabolisme asam arakidonat.
Tujuan: Penelitian ini membandingkan efektifitas tramadol 100 mg supp dan ketoprofen 100mg supp dalam mengurangi nyeri pasca operasi seksio sesaria.
Metode: Metode Penelitian ini observasi klinik karena sampel penelitian diobservasi sampai waktu tertentu untuk melihat efek yang timbul pada sampel penelitian. Total 48 pasien, yang terbagi dalam 2 kelompok. Kelompok Tramadol 24 pasien dan Kelompok Ketoprofen 24 pasien. Data Disajikan dalam bentuk nilai rerata ± simpang baku, kemudian diuji dengan menggunakan uji Mann Whitney dan Independent t-Test dengan (α = 0,05).
Hasil: Penurunan derajat nyeri pada pasien pasca seksio sesaria yang diberi tramadol 100mg supp lebih efektif dibanding dengan ketoprofen 100mg supp, p=0,000 (p,0,05).
Kesimpulan: terdapat perbedaan bermakna antara kelompok tramadol dan kelompok ketoprofen dalam menurunkan derajat nyeri, p=0,000 (p,0,05).
References
1. American Medical Association (AMA). 2007. Pathophysiology of Pain and Pain Managament.
2. ANZCA, 2010. Acute Pain Management Scientific Evidence, third edition. Australian and New Zealand College of Anasthetics and Faculty of Pain Medicine
3. Augusto, et al. 2002 Pain Measurement Tools and Methodsin Clinical Research in Palliative Care: Recommendations of an Expert Working Group of the European Associationof Palliative Care
4. Ataskhoyi S, Negargar S. 2008. Effect of Tramadol for Prevention of shivering after Spinal Anatshesia for Cesarean Section.
5. Chou R, Gordon DB, T, et al. 2016. Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists’ Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain Available from: http://dx.doi.org/10.1016/j.jpain.2015.12.008
6. Cunningham, F.G et all, 2012. Obstetri Williams, Ed 23. Vol 1. Jakarta : EGC
7. Dewoto HR. 2008. Analgesik Opioid dan Antagonis. In: Gunawan SG, Setiabudy R, Nafrialdi,
8. D. Gould et al, 2001. INFORMATION POINT:Visual Analogue Scale (VAS).Blackwell Science Ltd, Journal of Clinical Nursing.
9. Ferdianto. 2007. Rasionalitas Pemberian AnalgesikTramadol Pasca operasi Di Rumah Sakit DR, KariadiSemarang.
10. Goodman & Gilman. 2011. Manual FarmakologidanTerapi. Jakarta:EGC
11. Guyton Arthur, Hall John. 2008. Buku Ajar Patofisiologi Kedokteran. Edisi 11. EGC: Jakarta.
12. Helmes E, Barone P. 2008. Physiology and Treatment of Pain. Critical Care Nurse, Vol.28, no. 6, pp.38,40-46
13. Ifar IY, Hari HS, Himawan S. 2011. Obat-obat Anti Nyeri. Jurnal Anestesiologi Indonesia.
14. Ismail S, Afshan G, Monem A, Ahmed A, 2012. Postoperative Analgesia Following Caesarean Section : Intravenous Patient Controlled Analgesia versus Conventional Continuous Infusion.;2012(September):120–6.
15. Jabalameli M, Safavi M, Honarmand A, Saryazdi H, Moradi D, 2012. The comparison of intraincisional injection tramadol , pethidine and bupivacaine on postcesarean section pain relief under spinal anesthesia. 2012;1(3).
16. Jaury DF, Kumaat L, Tambajong HF, 2013. Gambaran Nilai Vas Pasca Bedah Seksio Sesar Pada Penderita Yang Diberikan Tramadol.
17. Jensen MP, Chen C, Brugger AM, 2003. Interpretation of visual analog scale ratings and change scores: A reanalysis of two clinical trials of postoperative pain. J Pain.
18. Katzung, Bertram G. 2013. Farmakologi Dasar dan Klinis. Edisi ke-12. Jakarta: Penerbit Buku Kedokteran EGC.
19. Lorimer,et al. 2004. A Randomized Controlled Trial of Intensive Neurophsyiology Education in Chronic Low Back Pain, Clinical Journal Pain, 20(5):324-30. Lippincott Williams & Wilkins: Australia
20. Merijwati, 2001. Evaluasi Efek Analgesi Pemakaian Ketoprofen dan Ketolorak Intravena Pasca Tonsilektomi.
21. Motoc D, Turtoi NC, Vasca V, Vasca E, Schneider F, Goldis V, 2010. Physiology of Pain – General Mechanisms and Individual Differences.;XIII(4):19–23
22. Nikolajsen L, et all 2004. Chronic Pain After Caesarean Section.
23. Ommais M, et all, 2012. Chronic Pain After Caesarean Section, Influence of Anasthetic/Surgical Tecnique and Postoperative Analgesia.
24. Patel NB, 2010. Chapter 3 Physiology of Pain Physiology of Pain Nociceptors and the Transduction.
25. Pritaningrum F. 2010. Perbedaan Skor Visual Analogue Scale Antara Ketolorak dan Deksketoprofen pada Pasien Pasca Bedah. Semarang : Fakultas Kedoktean Diponegoro
26. Putra AS, 2013. Perbandingan Kejadian Mual Muntah Pada Pemberian Tramadol Suppositori 100 Mg Dan Tramadol Intravena 100 Mg Sebagai Analgetik Paska Bedah Pada Operasi.
27. Rencber S et al, 2009. Bioavailability File : Ketoprofen.
28. Rochaniawan, R. (2012). Pengaruh Blok Paravertebra Injeksi Multipel Terhadap Nyeri Pasca Operasi Tumor Payudara Dinilai Dengan Visual Analogue Scale.
29. Rospond M. 2009. Penilaian nyeri[internet].
30. Sardjono, 2012. Farmakologi Fakultas Kedokteran Indonesia.
31. Sristava, et al, 2015. Efficacy of trans abdominis plane block for postcesarean delivery analgesia: A double-blind,randomized trial
32. Steeds CE, 2013. The Anatomy and Physiology of Pain. Surg (United Kingdom)[Internet].ElsevierLtd;;31(2):49–53.Available from:http://dx.doi.org/10.1016/j.mpsur.2009.10.013
33. Tamsuri. 2007. Konsep dan Penatalaksanaan Nyeri. Jakarta: EGC
34. Tariq, M.A., Qadirullah., Iqbal, Z. 2014. To Compare the Effect of Intrathecally Administered Tramadol Plus Bupivacaine with Bupivacaine Alone on the Duration of Post Operative Analgesia
35. Vadivelu et al, 2009. Pain Pathways and Acute Pain Processing.
36. Vyankatesh J et al., 2013. Comparative study of analgesic efficacy of rectal suppository of tramadol versus dicofenac in suppressing postoperative pain after Cesarean section.
37. Warden, V., Hurley, A., & Volicer, L. (2011). Faces Pain Scale Very Hurts just a little bit Hurts a little more Hurts even more Hurts a whole lot Hurts as much as you can imagine Visual Analog Scale ( VAS ) Pain Assessment of Infants Journal of the American Medical Directors Association. Journal of the American Medical Directors Association, 1–4. Retrieved from www.ttuhsc.edu/provost/clinic
38. World Health Organization,(2009). WHO’s Pain Relief Ladder. www.who.int/cancer/palliative/painladder/en/
39. WHO, 2014. Tramadol Update Review Report Expert comitte on Drug Dependence Thirty-six meeting.
2. ANZCA, 2010. Acute Pain Management Scientific Evidence, third edition. Australian and New Zealand College of Anasthetics and Faculty of Pain Medicine
3. Augusto, et al. 2002 Pain Measurement Tools and Methodsin Clinical Research in Palliative Care: Recommendations of an Expert Working Group of the European Associationof Palliative Care
4. Ataskhoyi S, Negargar S. 2008. Effect of Tramadol for Prevention of shivering after Spinal Anatshesia for Cesarean Section.
5. Chou R, Gordon DB, T, et al. 2016. Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists’ Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain Available from: http://dx.doi.org/10.1016/j.jpain.2015.12.008
6. Cunningham, F.G et all, 2012. Obstetri Williams, Ed 23. Vol 1. Jakarta : EGC
7. Dewoto HR. 2008. Analgesik Opioid dan Antagonis. In: Gunawan SG, Setiabudy R, Nafrialdi,
8. D. Gould et al, 2001. INFORMATION POINT:Visual Analogue Scale (VAS).Blackwell Science Ltd, Journal of Clinical Nursing.
9. Ferdianto. 2007. Rasionalitas Pemberian AnalgesikTramadol Pasca operasi Di Rumah Sakit DR, KariadiSemarang.
10. Goodman & Gilman. 2011. Manual FarmakologidanTerapi. Jakarta:EGC
11. Guyton Arthur, Hall John. 2008. Buku Ajar Patofisiologi Kedokteran. Edisi 11. EGC: Jakarta.
12. Helmes E, Barone P. 2008. Physiology and Treatment of Pain. Critical Care Nurse, Vol.28, no. 6, pp.38,40-46
13. Ifar IY, Hari HS, Himawan S. 2011. Obat-obat Anti Nyeri. Jurnal Anestesiologi Indonesia.
14. Ismail S, Afshan G, Monem A, Ahmed A, 2012. Postoperative Analgesia Following Caesarean Section : Intravenous Patient Controlled Analgesia versus Conventional Continuous Infusion.;2012(September):120–6.
15. Jabalameli M, Safavi M, Honarmand A, Saryazdi H, Moradi D, 2012. The comparison of intraincisional injection tramadol , pethidine and bupivacaine on postcesarean section pain relief under spinal anesthesia. 2012;1(3).
16. Jaury DF, Kumaat L, Tambajong HF, 2013. Gambaran Nilai Vas Pasca Bedah Seksio Sesar Pada Penderita Yang Diberikan Tramadol.
17. Jensen MP, Chen C, Brugger AM, 2003. Interpretation of visual analog scale ratings and change scores: A reanalysis of two clinical trials of postoperative pain. J Pain.
18. Katzung, Bertram G. 2013. Farmakologi Dasar dan Klinis. Edisi ke-12. Jakarta: Penerbit Buku Kedokteran EGC.
19. Lorimer,et al. 2004. A Randomized Controlled Trial of Intensive Neurophsyiology Education in Chronic Low Back Pain, Clinical Journal Pain, 20(5):324-30. Lippincott Williams & Wilkins: Australia
20. Merijwati, 2001. Evaluasi Efek Analgesi Pemakaian Ketoprofen dan Ketolorak Intravena Pasca Tonsilektomi.
21. Motoc D, Turtoi NC, Vasca V, Vasca E, Schneider F, Goldis V, 2010. Physiology of Pain – General Mechanisms and Individual Differences.;XIII(4):19–23
22. Nikolajsen L, et all 2004. Chronic Pain After Caesarean Section.
23. Ommais M, et all, 2012. Chronic Pain After Caesarean Section, Influence of Anasthetic/Surgical Tecnique and Postoperative Analgesia.
24. Patel NB, 2010. Chapter 3 Physiology of Pain Physiology of Pain Nociceptors and the Transduction.
25. Pritaningrum F. 2010. Perbedaan Skor Visual Analogue Scale Antara Ketolorak dan Deksketoprofen pada Pasien Pasca Bedah. Semarang : Fakultas Kedoktean Diponegoro
26. Putra AS, 2013. Perbandingan Kejadian Mual Muntah Pada Pemberian Tramadol Suppositori 100 Mg Dan Tramadol Intravena 100 Mg Sebagai Analgetik Paska Bedah Pada Operasi.
27. Rencber S et al, 2009. Bioavailability File : Ketoprofen.
28. Rochaniawan, R. (2012). Pengaruh Blok Paravertebra Injeksi Multipel Terhadap Nyeri Pasca Operasi Tumor Payudara Dinilai Dengan Visual Analogue Scale.
29. Rospond M. 2009. Penilaian nyeri[internet].
30. Sardjono, 2012. Farmakologi Fakultas Kedokteran Indonesia.
31. Sristava, et al, 2015. Efficacy of trans abdominis plane block for postcesarean delivery analgesia: A double-blind,randomized trial
32. Steeds CE, 2013. The Anatomy and Physiology of Pain. Surg (United Kingdom)[Internet].ElsevierLtd;;31(2):49–53.Available from:http://dx.doi.org/10.1016/j.mpsur.2009.10.013
33. Tamsuri. 2007. Konsep dan Penatalaksanaan Nyeri. Jakarta: EGC
34. Tariq, M.A., Qadirullah., Iqbal, Z. 2014. To Compare the Effect of Intrathecally Administered Tramadol Plus Bupivacaine with Bupivacaine Alone on the Duration of Post Operative Analgesia
35. Vadivelu et al, 2009. Pain Pathways and Acute Pain Processing.
36. Vyankatesh J et al., 2013. Comparative study of analgesic efficacy of rectal suppository of tramadol versus dicofenac in suppressing postoperative pain after Cesarean section.
37. Warden, V., Hurley, A., & Volicer, L. (2011). Faces Pain Scale Very Hurts just a little bit Hurts a little more Hurts even more Hurts a whole lot Hurts as much as you can imagine Visual Analog Scale ( VAS ) Pain Assessment of Infants Journal of the American Medical Directors Association. Journal of the American Medical Directors Association, 1–4. Retrieved from www.ttuhsc.edu/provost/clinic
38. World Health Organization,(2009). WHO’s Pain Relief Ladder. www.who.int/cancer/palliative/painladder/en/
39. WHO, 2014. Tramadol Update Review Report Expert comitte on Drug Dependence Thirty-six meeting.
Published
2018-12-14
How to Cite
Hadi, E. A., Kresnoadi, E., & Danianto, A. (2018). Efektifitas Tramadol 100mg Supp dibandingkan dengan Ketoprofen 100mg Supp untuk Mengurangi Nyeri Selama 24 Jam Pasca Operasi Seksio Sesaria dengan Menggunakan Vas Skor di Rumah Sakit Bhayangkara. Jurnal Kedokteran, 6(3.1). https://doi.org/10.29303/jku.v6i3.1.265
Issue
Section
Research
