Uji Aktivitas Antiparamphitomiasis Infus Bunga Widuri (Colotropis gigantea) Terhadap Paramphistomum spp. Secara In Vitro
DOI:
https://doi.org/10.29303/jku.v9i4.454Keywords:
Antiparamphistomiasis, infusa, bunga Calotropis giganteaAbstract
Latar Belakang: Prevalensi paramphistomiasis di provinsi Nusa Tenggara Barat tahun 2014 mencapai 20,7%. Tujuan penelitian untuk membandingkan aktivitas infus bunga Widuri berbagai konsentrasi terhadap Paramphistomum spp. secara in vitro terhadap Albendazol 10% b/v. Metode: Paramphistomum dewasa dikelompokkan ke dalam 5 kelompok : kontrol negatif (larutan NaCl 0,9% b/v), kontrol positif (Albendazol 10% b/v), dan infus bunga Widuri (5, 20 dan 40% b/v). Tiap kelompok diinkubasi pada suhu 37oC, kemudian diamati waktu kematian setiap 15 menit selama 5 jam. Persentase mortalitas ditentukan dan dianalisis secara statistik dengan parametrik dan non-parametrik menggunakan perangkat lunak SPSS v.16; Hasil: Rerata waktu kematian untuk tiap kelompok berturut-turut 270; 23,33 ± 5.77; 16,67 ± 11.55; 103,33 ± 5.77; dan 146,67 ± 5.77 menit. Kesimpulan: Infus bunga Widuri 5% b/v efektif sebagai antiparamphistomiasis ditinjau dari rerata waktu mortalitas yang berbeda bermakna (p<0,05) lebih rendah dibandingkan Albendazol 10% b/v.
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2.Melaku S, Addis M. Prevalence and intensity of Paramphistomum in ruminants slaughtered at Debre Zeit Industrial Abattoir, Ethiopia. Global Veterinaria. 2012 Mar;8(3):315–9.
3.Mastra IK, Saraswati NKH, Sutawijaya IMG, Yunanto. Surveilans dan monitoring parasit gastrointestinal pada sapi Bali di Propinsi Bali, Nusa Tenggara Barat dan Nusa Tenggara Timur. Buletin Veteriner, Balai Besar Veteriner Denpasar. 2014 Des;26(85):1-12.
4.Murtiyeni, Juarini E, Manurung J. Penyakit Parasit pada Ternak Ruminansia. Bogor: Balai Penelitian Veteriner. 2009.
5.Bilal MQ, Hameed A, Ahmad T. Prevalence of gastrointestinal parasites in buffalo and cow calves in Rural Areas of Toba Tek Singh, Pakistan. Journal of Animal and Plant Sciences. 2009 Aug;19(2):67-70.
6.Njoku TRF, Nwoko BEB. Prevalence of Paramphistomiasis among sheep slaughtered in some selected abattoirs in Imo State, Nigeria. Science World Journal. 2010 Feb;4(4):12-5.
7.Ilha MR, Loretti AP, Reis AC. Wasting and mortality in beef cattle parasitized by Eurytrema coelamaticum in the State of Parana, Southern Brazil. Veterinary Parasitology. 2005 Oct; 133(1):49-60.
8.Khan MK, Sajid MS, Khan MN, Iqbal Z, Iqbal MU. Bovine Fasciolosis: Prevalence, effects of treatment on productivity and cost benefit analysis in five districts of Punjab, Pakistan. Research in Veterinary Science. 2009;87(1):70-5.
9.Sardjono TW. Helmintologi kedokteran dan veteriner. Malang: UB Press; 2017. 169-170 p.
10.Toledo R, Fried, B, Editors. Digenetic trematodes. New York: Springer; 2014. 370, 382-5 p.
11.Taylor MA, Coop RL, Wall RL. Veterinary parasitology fourth edition. Oxford: Wiley Blackwell; 2016. 75, 80, 262, 353-4 p.
12.Hsu WH. Handbook of veterinary pharmacology. Ames: Wiley Blackwell; 2008. 380-1, 382-92 p.
13.Ramos F, Portella LP, Rodriguez FDS, Reginanto CZ, Cezar AS, Sanqioni LA, Vogel FSF. Anthelmintic resistance in gastrointestinal nematodes of beef cattle in the state of Rio Grande do Sul, Brazil. International Journal Parasitology Drugs Drug Resistence. 2016 Feb;6(1):93–101.
14.Kumarasingha R, Preston S, Yeo TC, Lim DSL, Tu CL, Palombo EA, Shaw JM, Gasser RB, Boag PR. Anthelmintic activity of selected ethno-medicinal plant extracts on parasitic stages of Haemonchus contortus. Parasites and Vectors. 2016 Apr;9(187):199-206.
15.Iqbal Z, Akhtar SM, Sindhu Z, Khan MN, Jabbar A. Herbal Dewormers in Livestock- A Traditional Therapy. International Journal of Agriculture and Biology. 2003 Jan;5(2):1-7.
16.Pullaiah T, Krishnamurty KV, Bahadur B, Editors. Ethnobotany of India Volume 1. Oakville: Apple Academic Press Inc; 2017. 303 p.
17.Mushir A, Jahan N, Ahmed A. A review on phytochemichal and biological properties of Colotropis gigantea (Linn.) R.Br. Discovery Phytomedicine. 2016 Jul;3(2):15-21.
18.Dongare SD, Mali SS, Dhanawade PP, Mali SS, Patrekar PV. In-vitro anthelmintic activity of Colotropis gigantea againts Indian earth worm Pheretima posthuma. International Journal of Institutional Pharmacy and Life Sciences. 2015 Jan;5(1):117-23.
19.Ahmad W. Preliminary phytochemichal, antimicrobial and photochemical study of Colotropis gigantea leaf exstract. Current Chemistry Latters. 2020 Sept;9(3)105-12.
20.Dash PR. Phytochemical Screening and Pharmacological Investigation on Hedychium coronarium. Hamburg: Anchor Academic Publishing. 2016; 41-2 p.
21.Raaman, N. Phytochemical Techniques. New Delhi: New India Publishing Agency. 2006; 19-2 p.
22.Departemen Kesehatan Republik Indonesia. Materia Medika Indonesia Jilid ke-3. Jakarta: Direktorat Jenderal Pengawasan Obat dan Makanan. 1979.
23.Seniya C, Trivedia SS, Verma SK. Antibacterial efficacy and phytochemical analysis of organic solvent extracts of Colotropis gigantea. 2011 Sept;3(6):330-6.
24.Badan Pengawas Obat dan Makanan Republik Indonesia. Peraturan Badan Pengawas Obat dan Makanan Nomor 11 tahun 2020 tentang Kriteria dan Tata Laksana Registrasi Suplemen Kesehatan. Jakarta: Badan Pengawas Obat dan Makanan Republik Indonesia. 2020.
25.Agrawal AA, Petschenka G, Bingham RA, Weber MG, Rasmann S. Toxic cardenolides: chemical ecology and coevolution of specialized plant-herbivore interactions. Tansley Review. 2012 Des; 194():24-45.
26.Martini R, Tresnani G, dan Pratama IS. Uji antelmintik in vitro ekstrak etanol daun turi (Sesbania grandiflora (l) pers.) terhadap ascaridia galli. BioWallacea Jurnal Ilmiah Ilmu Biologi. 2018 Sep;4(2):51-6.
27.Jones A. Superfamily Paramphistomoidea Fischoeder 1901. In: Jones A, Bray RA, dan Gibson, DI (Eds). Keys to the Trematoda, Vol. 2nd, London: Commonwealth Agricultural Bureau International Publishing and the Natural History Museum. 2005; 234-9 p.
28.Toyyibah Z. Uji efek antelmintik infus bunga widuri (Colotropis gigantea) (L.) Dryand terhadap cacing hati (Fasciola) secara in vitro. Skripsi. 2017.
29.Suryadi BF, Tresnani G, Pratama IS, dan Sukenti K. Pelatihan deteksi cacing parasit pada sapi dan uji coba pengobatan penyakit cacingan pada sapi menggunakan tanaman obat di desa Kesik, kecamatan Masbagik, kabupaten Lombok Timur. Jurnal Warta Desa. 2019 Des;1(3):301-10.
Ibekwe HA. In vitro anthelmintic activities of aqueous crude extract of Azadirachta indica on Paramphistomum cervi and Fasciola hepatica. International Journal of Veterinary Sciences and Animal Husbandry. 2019 Des;4(1): 14-8.
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Published
2021-01-11
How to Cite
Solehah, K. ., Damiyati, S. Y. ., Pratama, I. S., & Tresnani, G. . (2021). Uji Aktivitas Antiparamphitomiasis Infus Bunga Widuri (Colotropis gigantea) Terhadap Paramphistomum spp. Secara In Vitro. Jurnal Kedokteran, 9(4), 286–291. https://doi.org/10.29303/jku.v9i4.454
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