GANGGUAN HEMOSTASIS PADA PENYAKIT GINJAL KRONIK DERAJAT 5
DOI:
https://doi.org/10.29303/jku.v11i3.716Keywords:
Keywords : chronic kidney disease, dialysis, platelet dysfunction, hemostasisAbstract
Patients with chronic kidney disease (CKD) develop hemostatic disorders mainly in the form of bleeding diatheses. Platelet dysfunction is the main factor responsible for hemorrhagic tendencies in advanced kidney disease. Anemia, dialysis, the accumulation of medications due to poor clearance, and anticoagulation used during dialysis have some role in causing impaired hemostasis in CKD patients. Platelet dysfunction occurs both as a result of intrinsic platelet abnormalities and impaired platelet-vessel wall interaction. The normal platelet response to vessel wall injury with platelet activation, recruitment, adhesion, and aggregation is defective in advanced renal failure. Dialysis may partially correct these defects, but cannot totally eliminate them. The hemodialysis process itself may in fact contribute to bleeding. Hemodialysis is also associated with thrombosis as a result of chronic platelet activation due to contact with artificial surfaces during dialysis.
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21. Boccardo P, Remuzzi G (2004). Hemostasis in renal failure. Intensivemedizin und Notfallmedizin;35(6):382-9.
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2. Skorecki K, Green J, Brenner BM (2005). Chronic Renal Failure. In: Harrison’s Principles of Internal Medicine. 16th Edition. Volume 2. Mc Graw Hill ; 1653-63.
3. Hedges SJ, Dehoney SB, Hooper JS, et al (2007). Evidence-based treatment recommendations for uremic bleeding. Nature clinical practice nephrology. Vol 3, no 3 ;138-53.
4. Suharti C (2006). Dasar-dasar Hemostasis. Dalam: Buku Ajar Ilmu Penyakit Dalam. Jilid II. Edisi IV. ; 759-64.
5. Kaw D, Malhotra D (2006). Platelet Dysfunction and End-Stage Renal Disease. Hematology: Issues in the Dialysis Patient ; 317-22.
6. Handin RI (2005). Bleeding and thrombosis. In: Harrison’s Principles of Internal Medicine. 16th Edition. Mc Graw-Hill. Vol1; 337.
7. Boediwarsono (2007). Syndrome of thrombosis and hypercoagulability. Dalam: Current concepts of thrombosis (hematological aspect). Surabaya Hematologi Onkologi Medik Update-V ; 1-9.
8. George JN, Colman RW (2001). Overview of Platelet Structure and Function. In: Homestay and Thrombosis Basic Principles and Clinical Practice. 4th ed. Eds: Colman RW, Hirsh J, Marder VJ, et al. Lippincott Williams & Wilkins, Philadelphia ; 381-6.
9. Ganong WF(1995). Cairan Tubuh Bersirkulasi. Dalam: Buku Ajar Fisiologi Kedokteran. Edisi 14 ; 506-7.
10. Opie LH, White HD, Gersh BJ (2005). Antithrombotic Agents: Platelet Inhibitors, Anticoagulants, and Fibrinolytics. In: Drugs for the heart. Eds: Opie LH, Gersh BJ. Sixth Edition. Elsevier Saunders. Chapter 9 ; 275-80.
11. Levine SP (2004). Qualitative Disorders of Platelet Function. In: Wintrobe’s Clinical Hematology. Lippincott Williams and Wilkins. 11th edition. Vol.2 ; 1603-17.
12. Green D (2006). Coagulation Cascade. Hemodialysis International ;10 : 52-4.
13. Remuzzi G, Schieppati A, and Minetti L (2003). Anemia and Coagulopathy. In: Therapy in Nephrology and Hypertension. Eds: Brenner, Rector. Second Edition. Chapter 72 ; 689-700.
14. Sloand JA (2003). Platelet Dysfunction and coagulation defects. In: Comprehensive Clinical Nephrology. Eds: Johnson RJ, Hally JF. Mosby. 2nd Edition, Section 14, Chapter 71 ; 913-8.
15. Pranawa (2001). Anemia In Chronic Renal Failure : Focus On PERNEFRI Consensus of Anemia Management in Chronic Renal Failure. Dalam: Pendidikan Kedokteran Berkelanjutan XVI Ilmu Penyakit Dalam. FK Unair-RSUD Dr. Sutomo ;281-97.
16. Suwitra K (2006). Penyakit Ginjal Kronik. Dalam: Buku Ajar Ilmu Penyakit Dalam. Jilid I. Edisi IV ;581-4.
17. Bonomini M, Dottori, Amoroso L, et al (2004). Increased platelet phosphatidylserine exposure and caspase activation in chronic uremia. Journal of Thrombosis and Haemostasis;2:1275-81.
18. Charif R, Davenport A (2006). Heparin-induced thrombocytopenia: An uncommon but serious complication of heparin use in renal replacement therapy. Hemodialysis International;10:235-40.
19. Malyszko J, Malyszko JS, Mysliwiec M (2001). Comparison of hemostatic disturbances between patients on CAPD and patients on hemodialysis. Peri Dial Int 21(2): 158-65.
20. Fischer KG (2007). Essential of anti coagulation in hemodialysis. Hemodialysis International ;11(2):178-89.
21. Boccardo P, Remuzzi G (2004). Hemostasis in renal failure. Intensivemedizin und Notfallmedizin;35(6):382-9.
22. Vigano G, Noris M, Remuzzi G (1998). Coagulation disorders. In: Oxford Textbook of Clinical Nephrology. Eds: Davison AM, Cameron JS, Grunfeld JP, Kerr DN, Ritz E, Winearls CG. Oxford Medical Publications. Second Edition, Vol.3, Sections 11-20 ; 1989-93.
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Published
2022-10-28
How to Cite
Ketut Angga Aditya Putra Pramana. (2022). GANGGUAN HEMOSTASIS PADA PENYAKIT GINJAL KRONIK DERAJAT 5. Jurnal Kedokteran, 11(3), 1007–1014. https://doi.org/10.29303/jku.v11i3.716
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