GANGGUAN HEMOSTASIS PADA PENYAKIT GINJAL KRONIK DERAJAT 5

Penulis

  • Ketut Angga Aditya Putra Pramana Fakultas Kedokteran Universitas Mataram

DOI:

https://doi.org/10.29303/jku.v11i3.716

Kata Kunci:

Keywords : chronic kidney disease, dialysis, platelet dysfunction, hemostasis

Abstrak

Patients with chronic kidney disease (CKD) develop hemostatic disorders mainly in the form of bleeding diatheses. Platelet dysfunction is the main factor responsible for hemorrhagic tendencies in advanced kidney disease. Anemia, dialysis, the accumulation of medications due to poor clearance, and anticoagulation used during dialysis have some role in causing impaired hemostasis in CKD patients. Platelet dysfunction occurs both as a result of intrinsic platelet abnormalities and impaired platelet-vessel wall interaction. The normal platelet response to vessel wall injury with platelet activation, recruitment, adhesion, and aggregation is defective in advanced renal failure. Dialysis may partially correct these defects, but cannot totally eliminate them. The hemodialysis process itself may in fact contribute to bleeding. Hemodialysis is also associated with thrombosis as a result of chronic platelet activation due to contact with artificial surfaces during dialysis.

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Diterbitkan

2022-10-28

Cara Mengutip

Ketut Angga Aditya Putra Pramana. (2022). GANGGUAN HEMOSTASIS PADA PENYAKIT GINJAL KRONIK DERAJAT 5. Baphomet University : Situs Slot Online Gacor Terbaik Hari Ini Server Thailand Gampang Maxwin 2024, 11(3), 1007–1014. https://doi.org/10.29303/jku.v11i3.716

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