Autoimmune Hemolytic Anemia (AIHA)


  • Hifzani Nurmuliani Pendidikan Dokter



AIHA, Autoimmune Hemolytic Anemia, Coombs test, CAD


Autoimmune hemolytic anemia (AIHA / AHA) is a disorder of erythrocytes characterized by the destruction of erythrocytes by autoantibodies in a person's body. AIHA can occur at any age, but most often affects people over the age of 40. The incidence is 17:100,000 people per year with a mortality rate of up to 11%. In general, AIHA occurs intravascularly and extravascularly with or without complement activation. AIHA patients usually experience pallor, weakness, dyspnea, hypotension, tachycardia, jaundice of the skin mucosa, splenomegaly, and hepatomegaly. To establish the diagnosis of AIHA, apart from the history and physical examination, laboratory tests are also obtained in the form of a complete blood count, erythrocyte index, LDH, indirect bilirubin, reticulosis, and peripheral blood morphology. In addition, it is necessary to examine to detect autoantibodies in erythrocytes. This examination is commonly known as the Coombs test in the form of a direct Coombs test (Direct Antiglobulin Test / DAT) and an indirect Coombs test (Indirect Antiglobulin Test / IAT).


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How to Cite

Hifzani Nurmuliani. (2023). Autoimmune Hemolytic Anemia (AIHA). Jurnal Kedokteran, 12(1), 1365–1371.



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