Dinamika Ekspresi Cox1 dan Cox2 Sebagai Landasan Tatalaksana Nyeri dan Inflamasi
DOI:
https://doi.org/10.29303/jku.v11i4.868Keywords:
ekspresi, Cox1, Cox2, organAbstract
Siklooksigenase (COX) merupakan enzim yang sangat penting dalam menjaga homeostasis organ tubuh manusia. Enzim ini berperan pada kondisi fisiologis dan patologis khususnya saat terjadi inflamasi. Enzim ini memiliki 3 isoform yaitu Cox1, Cox2, dan Cox3. Isoform yang banyak diteliti dan terbukti sangat berperan dalam tubuh manusia adalah Cox1 dan Cox2, sedangkan Cox3 masih banyak perbedaan pendapat. Ekpresi Cox1 dan Cox2 dapat ditemukan pada berbagai organ dalam tubuh manusia, akan tetapi dalam naskah ini akan dibatasi pembahasannya pada lambung, ginjal, saraf, kardiovaskular, dan platelet. Hal ini dikaitkan dengan peran Cox sebagai target pengobatan nyeri dan inflamasi serta resiko efek samping yang mungkin ditimbulkannya. Perbedaan struktur kimia, karakter, serta perannya dalam menjaga homeostasis sangat perlu dipahami sebagai dasar penyusunan strategi pengobatan dan kewaspadaan terhadap efek samping yang dapat ditimbulkannya.
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14. Blanco FJ, Guitian R, Moreno J, de Toro FJ, Galdo F. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 1999 Jun;26(6):1366–73.
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2. Miciaccia M, Belviso BD, Iaselli M, Cingolani G, Ferorelli S, Cappellari M, et al. Three ? dimensional structure of human cyclooxygenase ( h COX )? 1. Sci Rep [Internet]. 2021;1–18. Available from: https://doi.org/10.1038/s41598-021-83438-z
3. Nørregaard R, Kwon T, Frøkiær J. Kidney Research and Clinical Practice Physiology and pathophysiology of cyclooxygenase-2 and prostaglandin E2 in the kidney. Kidney Res Clin Pract [Internet]. 2015;34(4):194–200. Available from: http://dx.doi.org/10.1016/j.krcp.2015.10.004
4. Willoughby DA, Moore AR, Colville-Nash PR. COX-1, COX-2, and COX-3 and the future treatment of chronic inflammatory disease. Lancet [Internet]. 2000;355(9204):646–8. Available from: https://www.sciencedirect.com/science/article/pii/S0140673699120312
5. Gudis K, Sakamoto C. The Role of Cyclooxygenase in Gastric Mucosal Protection. 2005;50(October):16–23.
6. Asif M. RESEARCH AND REVIEWS?: JOURNAL OF PHARMACEUTICS AND NANOTECHNOLOGY Development of Cyclooxygenases in the Treatment of Pain , Fever and. 2014;2(1):17–22.
7. Aïd S, Bosetti F. Targeting cyclooxygenases-1 and -2 in neuroinflammation: Therapeutic implications. Biochimie. 2011;93(1):46–51.
8. Félétou M, Huang Y, Vanhoutte PM. Endothelium-mediated control of vascular tone: COX-1 and COX-2 products. Br J Pharmacol. 2011;164(3):894–912.
9. Brooks P, Emery P, Evans JF, Fenner H, Hawkey CJ, Patrono C, et al. Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2. Rheumatology. 1999;38(8):779–88.
10. Rouzer CA, Marnett LJ. Cyclooxygenases: Structural and functional insights. J Lipid Res. 2009;50(SUPPL.):29–34.
11. Jackson LM, Wu KC, Mahida YR, Jenkins D, Hawkey CJ. Cyclooxygenase (COX) 1 and 2 in normal, inflamed, and ulcerated human gastric mucosa. Gut. 2000;47(6):762–70.
12. Day RO, Graham GG. The vascular effects of COX-2 selective inhibitors. Aust Prescr. 2004;27(6):142–5.
13. Sellers RS, Radi ZA, Khan NK. Pathophysiology of cyclooxygenases in cardiovascular homeostasis. Vet Pathol. 2010;47(4):601–13.
14. Blanco FJ, Guitian R, Moreno J, de Toro FJ, Galdo F. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 1999 Jun;26(6):1366–73.
15. Tegeder I. COX-1 and COX-2 in Pain. In: Gebhart GF, Schmidt RF, editors. Encyclopedia of Pain [Internet]. Berlin, Heidelberg: Springer Berlin Heidelberg; 2013. p. 791–4. Available from: https://doi.org/10.1007/978-3-642-28753-4_915
16. Steiner AA, Hunter JC, Phipps SM, Nucci TB, Oliveira DL, Roberts JL, et al. Cyclooxygenase-1 or -2--which one mediates lipopolysaccharide-induced hypothermia? Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R485-94.
17. Katzung BG. Katzung Basic & Clinical Pharmacology 12th Ed2. McGraw-Hill Education. 2018. 262–263 p.
18. Chou C-I, Shih C-J, Chen Y-T, Ou S-M, Yang C-Y, Kuo S-C, et al. Adverse Effects of Oral Nonselective and cyclooxygenase-2-Selective NSAIDs on Hospitalization for Acute Kidney Injury: A Nested Case-Control Cohort Study. Medicine (Baltimore). 2016 Mar;95(9):e2645.
19. Brunton, Laurence?; Parker, Keith; Blumental, Donald; Buxton L. Goodman & Gilman’s Manual of Pharmacology and Therapeutics. NewYork; 2008. 430 p.
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Published
2022-12-30
How to Cite
Mohammad Fathul Qorib. (2022). Dinamika Ekspresi Cox1 dan Cox2 Sebagai Landasan Tatalaksana Nyeri dan Inflamasi. Jurnal Kedokteran, 11(4), 1233–1239. https://doi.org/10.29303/jku.v11i4.868
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