Risk Factors Analysis of Thyroid Tumor In Family Cluster in The Coastal Area of West Nusa Tenggara Province

Authors

  • Athalita Andhera Nabil Athalita Andhera Nabil
  • Arina Windri Rivarti Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Mataram, Mataram, Indonesia
  • Legis Ocktaviana Saputri
  • Nurhidayati Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Mataram, Mataram, Indonesia

DOI:

https://doi.org/10.29303/jku.v12i3.967

Keywords:

thyroid tumors, risk factors, family claster, coastal area

Abstract

Background: Neoplasia is an uncontrolled growth of new tissue in the body, caused by uncontrolled gene mutations. One of the dominating endocrine neoplasia is thyroid neoplasia. Risk factors for thyroid tumors include age, place of residence, socioeconomics, and iodine intake. This study sampled families at risk of thyroid tumors at 6.1% who lived in the coastal province of West Nusa Tenggara (NTB) with an incidence rate of 0.85 per 100 population.                                      

Methode: This studied is analytics with a cross-sectional studied design. Sample in this studied was using rule of thumb with a total sample of 50 people who fit the inclusion criteria. This research used a google form which contains a series of questionnaires and short interviews. Hypothesis testing using fisher test with probability value (p) <0.05 and logistic regression.

Result: Iodine intake and age have association with the incidence of thyroid tumors, whereas Water Iodine Concentration (WIC) and socioeconomics have no association with p values ​​0.038, 0.009, 0.126, and 0.129. The most influential risk factor was iodine intake with an OR/exp. B of 243,132,352.0. The probability value of each family member with a risk factors is 59% and not with a risk factors of 0%.  

Conclusion: The risk factors that influence the incidence of thyroid tumors in the family cluster in this study are iodine intake and age.

Keywords: Thyroid tumors, risk factors, family cluster, coastal area.

References

Agodirin, O., Olatoke, S., Rahman, G., Kolawole, O., Oguntola, S., Olasehinde, O., Ayandipo, O., Olaogun, J., Katung, A., Etonyeaku, A., Habeeb, O., Adeyeye, A., Agboola, J., Akande, H., Akanbi, O., Fatudimu, O., & Ajiboye, A. (2021). Determinants of late detection and advanced-stage diagnosis of breast cancer in Nigeria. PLoS ONE, 16(November), 1–13. https://doi.org/10.1371/journal.pone.0256847

Aldi R.H., M., Trisnandari, L., Ikaputra, Aldi, M. R. H., A., L. T., & Ikaputra. (2019). Karakteristik dan pola kampung nelayan. Tesa Arsitektur, 17(2), 115–126.

Ari Pratiwi, D., Sekar Prihanti, G., & Endra Budi Setyawan, F. (2017). Hubungan Antara Pengetahuan Keluarga Dan Pola Konsumsi Pangan Terhadap Kejadian Gondok Pada Anak Usia Sekolah Di Sdn Pandansari 02 Kecamatan Poncokusumo Kabupaten Malang. Saintika Medika, 11(1), 45. https://doi.org/10.22219/sm.v11i1.4195

Bryere, J., Dejardin, O., Bouvier, V., Colonna, M., Guizard, A. V., Troussard, X., Pornet, C., Galateau-Salle, F., Bara, S., Launay, L., Guittet, L., & Launoy, G. (2014). Socioeconomic environment and cancer incidence: A French population-based study in Normandy. BMC Cancer, 14(1), 1–10. https://doi.org/10.1186/1471-2407-14-87

Crosby, H., Pontoh, V., & Marselus, A. M. (2016). Pola kelainan tiroid di RSUP Prof . Dr . R . D . Kandou Manado periode Januari 2013-2015. Jurnal E-Clinic (ECI), 4(1), 430–437.

Dahlan, M. S. (2013). Statistik untuk Kedokteran dan Kesehatan: Deskriptif, Bivariat, dan Multivariat, Dilengkapi AAplikasi dengan Menggunakan SPSS.

Diab, N., Daya, N. R., Juraschek, S. P., Martin, S. S., McEvoy, J. W., Schultheiß, U. T., Köttgen, A., & Selvin, E. (2019). Prevalence and Risk Factors of Thyroid Dysfunction in Older Adults in the Community. Scientific Reports, 9(1), 1–8. https://doi.org/10.1038/s41598-019-49540-z

Dinkes NTB. (2020). Profil Kesehatan NTB Tahun 2020. Dinas Kesehatan NTB, 100.

Diskominfo. (2021). INFORMASI IKLIM DASARIAN PROVINSI NTB UPDATE 10 DESEMBER 2021. https://diskominfo.dompukab.go.id/baca-berita-1177-informasi-iklim-dasarian-provinsi-ntb-update-10-desember-2021.html

Elias, E., Tsegaye, W., Stoecker, B. J., & Gebreegziabher, T. (2021). Excessive intake of iodine and low prevalence of goiter in school age children five years after implementation of national salt iodization in Shebedino woreda, southern Ethiopia. BMC Public Health, 21(1), 1–8. https://doi.org/10.1186/s12889-021-10215-y

Fitria, E. Z. C., Rumastika, N. S., & Wulandari, P. (2020). Association Between Risk Factors with The Event of Nasopharynx Carcinoma in Soebandi Hospital Period Of January 2017- March 2019. Journal of Agromedicine and Medical Sciences, 6(3), 130. https://doi.org/10.19184/ams.v6i3.13814

Fitzmaurice, C., Abate, D., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdel-Rahman, O., Abdelalim, A., Abdoli, A., Abdollahpour, I., Abdulle, A. S. M., Abebe, N. D., Abraha, H. N., Abu-Raddad, L. J., Abualhasan, A., Adedeji, I. A., Advani, S. M., Afarideh, M., Afshari, M., Aghaali, M., … Murray, C. J. L. (2019). Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-Adjusted life-years for 29 cancer groups, 1990 to 2017: A systematic analysis for the global burden of disease study. In JAMA Oncology (Vol. 5, Issue 12, pp. 1749–1768). https://doi.org/10.1001/jamaoncol.2019.2996

Julkrismi, E. (2018). Pengaruh Pola Kehidupan Masyarakat Pesisir Terhadap Pola Pemukiman Dipantai Pasar Bawah. Proceeding of The URECOL, 170–181.

Kimlin, M. G., Youlden, D. R., Brodie, A. M., DiSipio, T., Youl, P., Nair-Shalliker, V., & Baade, P. D. (2019). Risk of Second Primary Cancer in Survivors of In Situ Melanoma. Journal of Investigative Dermatology, 139(4), 842–847. https://doi.org/10.1016/j.jid.2018.11.001

Kumar V, Cotran RS, R. S. (2007). Buku ajar patologi, (7th ed, Vo). Penerbit Buku Kedokteran EGC.

Kumorowulan, S., Wahyuningrum, S. N., Kusrini, I., Sukandar, P. B., Kusumawardani, H. D., Riyanto, S., Prihatmi, E. B., Sudarinah, S., Mulyani, D., Astuti, B. D., & Janah, N. A. (2019). Hubungan Status Iodium Dengan Fungsi Tiroid Di Kota Yogyakarta, Kabupaten Purworejo, Dan Kota Bukittinggi. Media Gizi Mikro Indonesia, 11(1), 15–24. https://doi.org/10.22435/mgmi.v11i1.2530

Ling-zhi Cao, et al. (2017). The Relationship Between Iodine Intake and The Risk of Thyroid Cancer : A Meta-analysis (p. 6).

Longheu, A., Medas, F., Pisano, G., Gordini, L., Nicolosi, A., Sorrenti, S., Erdas, E., & Calò, P. G. (2016). Differentiated thyroid cancer in patients ≥75 years: Histopathological features and results of surgical treatment. International Journal of Surgery, 33, S159–S163. https://doi.org/10.1016/j.ijsu.2016.07.001

Nurlatifah, A., & Wulandari, E. P. (2020). Analysis of Rainfall Conditions Over Nusa Tenggara Barat During Enso Events Based on Trmm Data (Analisis Kondisi Curah Hujan Di Nusa Tenggara Barat Selama Terjadinya Enso Berdasarkan Data Trmm). 17(1), 49–60. https://doi.org/10.30536/j.jsd.2020.v17.a3123

Parura, Y., Pontoh, V., & Werung, M. (2016). Pola kanker tiroid periode Juli 2013 – Juni 2016 di RSUP Prof. Dr. R. D Kandou Manado. E-CliniC, 4(2). https://doi.org/10.35790/ecl.4.2.2016.14475

Putri, E., Khambri, D., & Rusjdi, S. R. (2017). Artikel Penelitian Hubungan Daerah Tempat Tinggal dengan Gambaran Histopatologi Karsinoma Tiroid pada Masyarakat Sumatera Barat. 6(1), 171–174.

Rahayuwati, L., Rizal, Iqbal, A., Lukman, M., & Juniarti, N. (2020). Pendidikan Kesehatan tentang Pencegahan Penyakit Kanker dan Menjaga Kualitas Kesehatan. Media Karya Kesehatan, 3(1), 59–69.

Sidemen, I. G. A. P. Y. (2022). NODUL TIROID SOLITER. Syria Studies, 7(1), 37–72. https://www.researchgate.net/publication/269107473_What_is_governance/link/548173090cf22525dcb61443/download%0Ahttp://www.econ.upf.edu/~reynal/Civil wars_12December2010.pdf%0Ahttps://think-asia.org/handle/11540/8282%0Ahttps://www.jstor.org/stable/41857625

Wang, H., Jiang, Y., Song, J., Liang, H., Liu, Y., Huang, J., Yin, P., Wu, D., Zhang, H., Liu, X., Zhou, D., Wei, W., Lei, L., Peng, J., & Zhang, J. (2022). The risk of perchlorate and iodine on the incidence of thyroid tumors and nodular goiter: a case-control study in southeastern China. Environmental Health: A Global Access Science Source, 21(1), 1–12. https://doi.org/10.1186/s12940-021-00818-8

Yulianti, I., Santoso, H., & Sutinigsih, D. (2016). Faktor-Faktor Risiko Kanker Payudara (Studi Kasus Pada Rumah Sakit Ken Saras Semarang). Jurnal Kesehatan Masyarakat Universitas Diponegoro, 4(4), 401–409.

Zimmermann, M. B., & Galetti, V. (2015). Iodine intake as a risk factor for thyroid cancer: A comprehensive review of animal and human studies. In Thyroid Research (Vol. 8, Issue 1). https://doi.org/10.1186/s13044-015-0020-8

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Published

2023-10-25

How to Cite

Nabil, A. A., Arina Windri Rivarti, Legis Ocktaviana Saputri, & Nurhidayati. (2023). Risk Factors Analysis of Thyroid Tumor In Family Cluster in The Coastal Area of West Nusa Tenggara Province. Jurnal Kedokteran, 12(3), 280–286. https://doi.org/10.29303/jku.v12i3.967

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