Omega-3 Memiliki Banyak Manfaat: Apakah Bisa Melawan Kanker?


  • Ahda Fatikha Rudia
  • Hendriani Aulia Dwi
  • Negara Baiq Ramdhani Amelia
  • Radwa Ghanniya Atifah
  • Nurhidayati



Abstract: Cancer is the biggest cause of death in the world, around 10 million deaths are caused by cancer. In 2020, 17 million new cases were recorded, of which 8.5 million people died each year from cancer, while 66% of patients can live up to 5 years after being diagnosed and 40% of patients can live more than 10 years after being diagnosed. Various prevention efforts against risk factors have been carried out. The main modalities of cancer therapy today are surgery, chemotherapy, and radiation with the choice of therapy based on the stage of the cancer. Research shows that giving omega-3 supplementation to patients undergoing chemotherapy is considered very beneficial because omega-3 works synergistically with chemotherapeutic agents and can also be used to increase the radiosensitivity of tumor cells so that it has a good impact on the success of therapy.


Asl, E. R., Rostamzadeh, D., Duijf, P. H. G., Mafi, S.,

Mansoori, B., Barati, S., Cho, W. C., & Mansoori, B.

(2023). Mutant P53 in the formation and progression

of the tumor microenvironment: Friend or foe. Life

sciences, 315, 121361.

Ayubi, N., Purwanto, B. and Rejeki, P. S. (2020) ‘Efek

Suplementasi Omega 3 dan Latihan Fisik Terhadap

Respon Inflamasi’, JOSSAE : Journal of Sport Science

and Education, 5(2), p. 116. doi:


Borek, C. (2017) ‘Dietary Antioxidants and Human

Cancer’, Journal of Restorative Medicine, 6(1), pp. 53–61.

doi: 10.14200/jrm.2017.6.0105.

Budhy, T. I., 2019. Mengapa Terjadi Kanker. 2nd ed.

Surabaya: Airlangga University Press.

Caruso, G. et al. (2020) ‘Fishery Wastes as a Yet

Undiscovered Treasure from the Sea: Biomolecules

Sources, Extraction Methods and Valorization’,

Marine Drugs, 18(12). doi: 10.3390/md18120622.

Cheng, M., Zhang, S., Ning, C., & Huo, Q. (2021).

Omega-3 Fatty Acids Supplementation Improve

Nutritional Status and Inflammatory Response in

Patients With Lung Cancer: A Randomized Clinical

Jurnal Kedokteran Unram June 2023, 12 (2), 217 – 221

Trial. Frontiers in nutrition, 8, 686752.

Dempsey, M., Rockwell, M. S., & Wentz, L. M. (2023).

The influence of dietary and supplemental omega-3

fatty acids on the omega-3 index: A scoping

review. Frontiers in

Nutrition, 10.

Figueiredo, A. R. P. et al. (2019) ‘The Effects of Different

Extraction Methods of Lipids from Nannochloropsis

oceanica on The Contents of Omega-3 Fatty Acids’,

Algal Research, 41(December 2018), p. 101556. doi:


Freitas, R. D. S. and Campos, M. M. (2019) ‘Protective

Effects of Omega-3 Fatty Acids in Cancer-Related

Complications’, Nutrients, pp. 1–23.

Gellrich, N. C. et al. (2015) ‘Oral cancer malnutrition

impacts weight and quality of life’, Nutrients, 7(4), pp.

–2160. doi: 10.3390/nu7042145.

Gutiérrez, S., Svahn, S. L. and Johansson, M. E. (2019)

‘Effects of Omega-3 Fatty Acids on Immune Cells’,

International Journal of Molecular Sciences, 20(20).

doi: 10.3390/ijms20205028.

Hausman, D.M. (2019). What Is Cancer?Perspectives in

Biology and Medicine 62(4), 778-784.


Huerta-Yépez, S., Tirado-Rodriguez, A. B. and

Hankinson, O. (2016) ‘Papel de las dietas ricas en

omega-3 y omega-6 en el desarrollo del cáncer’,

Boletin Medico del Hospital Infantil de Mexico, 73(6), pp.

–456. doi: 10.1016/j.bmhimx.2016.11.001.

Innis, S. M. (2014). Omega-3 Fatty Acid Biochemistry:

Perspectives from Human Nutrition. Military

Medicine, 179(11S), 82–

Klek S. (2016). Omega-3 Fatty Acids in Modern

Parenteral Nutrition: A Review of the Current

Evidence. Journal of clinical medicine, 5(3), 34.

Lavy, M. et al. (2021) ‘Specialized Pro-Resolving

Mediators Mitigate Cancer-Related Inflammation:

Role of Tumor-Associated Macrophages and

Therapeutic Opportunities’, Frontiers in Immunology,

(June), pp. 1–19. doi: 10.3389/fimmu.2021.702785.

Leuzzi, G. et al. (2016) ‘Baseline C-reactive protein level

predicts survival of early-stage lung cancer: Evidence

from a systematic review and meta-analysis’, Tumori,

(5), pp. 441–449. doi: 10.5301/tj.5000522.

Mansara, P. et al. (2015) ‘Improved antioxidant status by

omega-3 fatty acid supplementation in breast cancer

patients undergoing chemotherapy: A case series’,

Journal of Medical Case Reports, 9(1), pp. 1–6. doi:


Melgosa, R., Sanz, M. T. and Beltrán, S. (2021)

‘Supercritical CO2 Processing of Omega-3

Polyunsaturated Fatty Acids – Towards a Biorefinery

for Fish Waste Valorization’, Journal of Supercritical

Fluids, 169. doi: 10.1016/j.supflu.2020.105121.

Muscaritoli, M. et al. (2021) ‘ESPEN practical guideline:

Clinical Nutrition in cancer’, Clinical Nutrition, 40(5),

pp. 2898–2913. doi: 10.1016/j.clnu.2021.02.005.

Paixão, E. M. D. S. et al. (2017) ‘The effects of EPA and

DHA enriched fish oil on nutritional and

immunological markers of treatment naïve breast

cancer patients: A randomized double-blind

controlled trial’, Nutrition Journal, 16(1), pp. 1–11. doi:


Qi, X. et al. (2022) ‘Antioxidants in brain tumors: current

therapeutic significance and future prospects’,

Molecular Cancer, 21(1), pp. 1–32. doi: 10.1186/s12943-


Robbins, O. (2021). Omega-3s: Why Are They Important

— And What Are the Best Sources for Your Health?

(Updated August 17, 2021). Akses gambar pada:

Samanta, C. et al. (2022) ‘Omega-3 Fatty Acid and its

Protective Effect against Cancer and Cancer-related

Complication’, Journal of Pharmaceutical Research

International, 34, pp. 51–62. doi:


Santos, H. O., May, T. L., & Bueno, A. A. (2023). Eating

more sardines instead of fish oil supplementation:

Beyond omega-3 polyunsaturated fatty acids, a

matrix of nutrients with cardiovascular

benefits. Frontiers in

Nutrition, 10.

Sari, L. M. (2018) ‘Apoptosis: Mekanisme Molekuler

Kematian Sel’, Cakradonya Dental Journal, 10(2), pp.

–70. doi: 10.24815/cdj.v10i2.11701.

Sun SN, Jia WD, Chen H, Ma JL, Ge YS, Yu JH, Li JS.

Docosahexaenoic acid (DHA) induces apoptosis in

human hepatocellular carcinoma cells. International

Journal of Clinical and Experimental Pathology.


Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M.,

Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global

Cancer Statistics 2020: GLOBOCAN Estimates of

Incidence and Mortality Worldwide for 36 Cancers in

Countries. CA: a cancer journal for clinicians, 71(3),


Tantipaiboonwong, P. et al. (2021) ‘Molecular

mechanism of antioxidant and anti-inflammatory

effects of omega-3 fatty acids in perilla seed oil and

rosmarinic acid rich fraction extracted from perilla

seed meal on TNF-α induced A549 lung

adenocarcinoma cells’, Molecules, 26(22). doi:


Tao, X., Zhou, Q., & Rao, Z. (2022). Efficacy of ω-3

Polyunsaturated Fatty Acids in Patients with Lung

Jurnal Kedokteran Unram June 2023, 12 (2), 217 – 221

Cancer Undergoing Radiotherapy and

Chemotherapy: A Meta-Analysis. International

Journal of Clinical Practice, 2022, 1–




How to Cite

Rudia, A. F., Dwi, H. A., Amelia, N. B. R., Atifah, R. G., & Nurhidayati. (2023). Omega-3 Memiliki Banyak Manfaat: Apakah Bisa Melawan Kanker?. Jurnal Kedokteran, 12(2).



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