Beberapa Khasiat Buah Tin (Ficus Carica) Dari Antikonvulsan, Anti Alergik, Anti Inflamasi, Antihiperglikemik, Antitumor, Anti Kanker Hingga Terapi Hati
DOI:
https://doi.org/10.29303/jku.v9i3.409Abstrak
Buah tin (Ficus carica) adalah sumber zat besi, kalsium, fosfor, dan serat. Buah tin telah digunakan di seluruh dunia untuk mengobati berbagai gangguan kesehatan. Ficus carica Berasal dari Timur Tengah dan Asia Barat, tetapi menyebar ke banyak wilayah lain di dunia. Produk dari Ficus carica banyak digunakan sebagai sumber makanan dan obat-obatan untuk mengobati berbagai penyakit. Berdasarkan uraian yang disebutkan, maka peneliti tertarik untuk mengkaji lebih lanjut mengenai manfaat yang terkandung dalam Buah tin.
Referensi
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7. Mashile SP, Tshisikhawe MP, Masevhe NA. Indigenous fruit plants species of the Mapulana of Ehlanzeni district in Mpumalanga province, South Africa. South African J Bot [Internet]. 2019;122:180–3. Available from: https://doi.org/10.1016/j.sajb.2018.09.031
8. Nirwana I, Rianti D, Helal Soekartono R, Listyorini RD, Basuki DP. Antibacterial activity of fig leaf (Ficus carica Linn.) extract against Enterococcus faecalis and its cytotoxicity effects on fibroblast cells. Vet World. 2018;11(3):342–7.
9. Ling WT, Liew FC, Lim WY, Subramaniam S, Chew BL. Shoot induction from axillary shoot tip explants of fig (Ficus carica) cv. japanese BTM 6. Trop Life Sci Res. 2018;29(2):165–74.
10. Zhang Y, Wan Y, Huo B, Li B, Jin Y, Hu X. Extracts and components of ficus carica leaves suppress survival, cell cycle, and migration of triple-negative breast cancer MDA-MB-231 cells. Onco Targets Ther. 2018;11:4377–86.
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14. Comparin BC, Santos CHM dos, Dourado DM, Reichel PMG, Paola RS de, Pontes ERJC. Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extract. J Coloproctology [Internet]. 2018;38(4):283–9. Available from: http://dx.doi.org/10.1016/j.jcol.2018.05.009
15. Aldhebiani AY, Elbeshehy EKF, Baeshen AA, Elbeaino T. Inhibitory activity of different medicinal extracts from Thuja leaves, ginger roots, Harmal seeds and turmeric rhizomes against Fig leaf mottle-associated virus 1 (FLMaV-1) infecting figs in Mecca region. Saudi J Biol Sci [Internet]. 2017;24(4):936–44. Available from: http://dx.doi.org/10.1016/j.sjbs.2015.11.005
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18. Mijit M, HE Z, HONG J, LU M guang, LI S fang, ZHANG Z xiang. Analysis of fig tree virus type and distribution in China. J Integr Agric [Internet]. 2017;16(6):1417–21. Available from: http://dx.doi.org/10.1016/S2095-3119(16)61551-4
19. Raafat K, Wurglics M. Phytochemical analysis of Ficus carica L. active compounds possessing anticonvulsant activity. J Tradit Complement Med [Internet]. 2019;9(4):263–70. Available from: https://doi.org/10.1016/j.jtcme.2018.01.007
20. Yeganehzad S, Kiumarsi M, Nadali N, Rabie Ashkezary M. Formulation, development and characterization of a novel functional fruit snack based on fig (Ficus carica L.) coated with sugar-free chocolate. Heliyon [Internet]. 2020;6(7):e04350. Available from: https://doi.org/10.1016/j.heliyon.2020.e04350
21. Lu X, Wo G, Li B, Xu C, Wu J, Jiang C, et al. The anti-inflammatory NHE-06 restores antitumor immunity by targeting NF-?B/IL-6/STAT3 signaling in hepatocellular carcinoma. Biomed Pharmacother [Internet]. 2018;102(December 2017):420–7. Available from: https://doi.org/10.1016/j.biopha.2018.03.099
22. Turan A, Celik I. Antioxidant and hepatoprotective properties of dried fig against oxidative stress and hepatotoxicity in rats. Int J Biol Macromol [Internet]. 2016;91:554–9. Available from: http://dx.doi.org/10.1016/j.ijbiomac.2016.06.009
23. Zhang Y, Li Y, Ma P, Chen J, Xie W. Ficus carica leaves extract inhibited pancreatic ?-cell apoptosis by inhibiting AMPK/JNK/caspase-3 signaling pathway and antioxidation. Biomed Pharmacother [Internet]. 2020;122(November 2019):109689. Available from: https://doi.org/10.1016/j.biopha.2019.109689
24. Abbasi S, Kamalinejad M, Babaie D, Shams SM, Sadr Z, Gheysari M, et al. A new topical treatment of atopic dermatitis in pediatric patients based on Ficus carica L. (Fig): A randomized, placebo-controlled clinical trial. Complement Ther Med [Internet]. 2017;35(August 2017):85–91. Available from: http://dx.doi.org/10.1016/j.ctim.2017.10.003
25. Hedayat KM, Lapraz J-C. A general Endobiogenic approach to regulation of the immune system. The Theory of Endobiogeny. 2019;49–61.
26. Essid A, Aljane F, Ferchichi A. Morphological characterization and pollen evaluation of some Tunisian ex situ planted caprifig (Ficus carica L.) ecotypes. South African J Bot [Internet]. 2017;111:134–43. Available from: http://dx.doi.org/10.1016/j.sajb.2017.03.001
27. Hamed MB, El-Badry MO, Kandil EI, Borai IH, Fahmy AS. A contradictory action of procoagulant ficin by a fibrinolytic serine protease from Egyptian Ficus carica latex. Biotechnol Reports [Internet]. 2020;27:e00492. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2215017X20302988
28. Hald MM, Magnussen B, Appel L, Christensen JT, Hansen CH, Henriksen PS, et al. Fragments of meals in eastern Denmark from the Viking Age to the Renaissance: New evidence from organic remains in latrines. J Archaeol Sci Reports [Internet]. 2020;31(April):102361. Available from: https://doi.org/10.1016/j.jasrep.2020.102361
29. Ayoub L, Hassan F, Hamid S, Abdelhamid Z, Souad A. Phytochemical screening, antioxidant activity and inhibitory potential of Ficus carica and Olea europaea leaves. Bioinformation. 2019;15(3):226–32.
30. Bayoudh C, Elair M, Labidi R, Majdoub A, Mahfoudhi N, Mars M. Efficacy of tissue culture in virus elimination from caprifig and female fig varieties (Ficus carica L.). Plant Pathol J. 2017;33(3):288–95.
31. Mopuri R, Ganjayi M, Meriga B, Koorbanally NA, Islam MS. The effects of Ficus carica on the activity of enzymes related to metabolic syndrome. J Food Drug Anal [Internet]. 2018;26(1):201–10. Available from: https://doi.org/10.1016/j.jfda.2017.03.001
32. Mahjour M, Khoushabi A, Miri Ghale Novi M, Feyzabadi Z. Food strategies of renal atrophy based on Avicenna and conventional medicine. J Tradit Complement Med [Internet]. 2017;7(4):375–9. Available from: https://doi.org/10.1016/j.jtcme.2016.12.004
33. Ergül M, Ergül M, Eruygur N, Ata? M, Uçar E. In vitro evaluation of the chemical composition and various biological activities of ficus carica leaf extracts. Turkish J Pharm Sci. 2019;16(4):401–9.
34. Widyaningrum N, Hussana A, Adi RS, Tiastuti M, Utami KM, Kedokteran F, et al. Jurnal Farmasi Sains dan Praktis AKTIFITAS SITOTOKSIK KOMBINASI EKSTRAK BUAH TIN DAN MINYAK ZAITUN TERHADAP SEL KANKER PAYUDARA CYTOTOXIC ACTIVITY OF COMBINED FIG EXTRACT AND OLIVE OIL AGAINST BREAST CANCER CELLS. 2020;6(1):1–8.
35. Lazreg-Aref H, Gaaliche B, Ladhari A, Hammami M, Hammami SO. Co-evolution of enzyme activities and latex in fig (Ficus carica L.) during fruit maturity process. South African J Bot [Internet]. 2018;115:143–52. Available from: https://doi.org/10.1016/j.sajb.2018.01.022
36. Gaaliche B, Ladhari A, de Medeiros AG, Ben Mimoun M, Hajlaoui MR. Relationship between phytochemical profiles and phytotoxic proprieties of Tunisian fig leaf cultivars. South African J Bot [Internet]. 2017;112:322–8. Available from: http://dx.doi.org/10.1016/j.sajb.2017.06.015
37. Allegra A, Gallotta A, Carimi F, Mercati F, Inglese P, Martinelli F. Metabolic profiling and post-harvest behavior of “dottato” fig (Ficus carica L.) fruit covered with an edible coating from O. ficus-indica. Front Plant Sci. 2018;9(September):1–10.
38. Ahmed S, Hasan MM, Khan H, Mahmood ZA, Patel S. The mechanistic insight of polyphenols in calcium oxalate urolithiasis mitigation. Biomed Pharmacother [Internet]. 2018;106(July 2018):1292–9. Available from: https://doi.org/10.1016/j.biopha.2018.07.080
39. Mori K, Shirasawa K, Nogata H, Hirata C, Tashiro K, Habu T, et al. Corrigendum: Identification of RAN1 orthologue associated with sex determination through whole genome sequencing analysis in fig (Ficus carica L.) (Scientific Reports, (2017), 7, 1, (41124), 10.1038/srep41124). Sci Rep. 2017;7(1):1–3.
40. Nadeem M, Zeb A. Impact of maturity on phenolic composition and antioxidant activity of medicinally important leaves of Ficus carica L. Physiol Mol Biol Plants [Internet]. 2018;24(5):881–7. Available from: https://doi.org/10.1007/s12298-018-0550-3
41. Naghdi M, Maghbool M, Seifalah-Zade M, Mahaldashtian M, Makoolati Z, Kouhpayeh SA, et al. Effects of common fig (Ficus carica) leaf extracts on sperm parameters and testis of mice intoxicated with formaldehyde. Evidence-based Complement Altern Med. 2016;2016:18–20.
42. Agustina E. Uji Aktivitas Senyawa Antioksidan Dari Ekstrak Daun Tiin (Ficus carica Linn) dengan Pelarut Air, Metanol dan Campuran Metanol-Air. Klorofil. 2017;1(1):38–47.
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44. Bouyahya A, Abrini J, Et-Touys A, Bakri Y, Dakka N. Indigenous knowledge of the use of medicinal plants in the North-West of Morocco and their biological activities. Eur J Integr Med [Internet]. 2017;13(March 2017):9–25. Available from: http://dx.doi.org/10.1016/j.eujim.2017.06.004
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2. Choubane S, Cheba BA, Benourrad A. Screening and Phenotypic Diversity of Amylase Producing Rhizospheric Bacteria from Some North African Plants. Procedia Technol. 2016;22:1197–204.
3. Fernandez-Flores A, Llamas Velasco M, Saeb Lima M. Guarumbo (Cecropia obtusifolia) for Warts in Zapotec Medicine. Actas Dermosifiliogr [Internet]. 2020;111(3):189–91. Available from: http://dx.doi.org/10.1016/j.adengl.2018.10.027
4. Alzahrani HR, Kumakli H, Ampiah E, Mehari T, Thornton AJ, Babyak CM, et al. Determination of macro, essential trace elements, toxic heavy metal concentrations, crude oil extracts and ash composition from Saudi Arabian fruits and vegetables having medicinal values. Arab J Chem [Internet]. 2017;10(7):906–13. Available from: https://doi.org/10.1016/j.arabjc.2016.09.012
5. Chai L, Chai P, Chen S, Flaishman MA, Ma H. Transcriptome analysis unravels spatiotemporal modulation of phytohormone-pathway expression underlying gibberellin-induced parthenocarpic fruit set in San Pedro-type fig (Ficus carica L.). BMC Plant Biol. 2018;18(1):1–15.
6. Sharma SH, Kumar JS, Chellappan DR, Nagarajan S. Molecular chemoprevention by morin – A plant flavonoid that targets nuclear factor kappa B in experimental colon cancer. Biomed Pharmacother [Internet]. 2018;100(December 2017):367–73. Available from: https://doi.org/10.1016/j.biopha.2018.02.035
7. Mashile SP, Tshisikhawe MP, Masevhe NA. Indigenous fruit plants species of the Mapulana of Ehlanzeni district in Mpumalanga province, South Africa. South African J Bot [Internet]. 2019;122:180–3. Available from: https://doi.org/10.1016/j.sajb.2018.09.031
8. Nirwana I, Rianti D, Helal Soekartono R, Listyorini RD, Basuki DP. Antibacterial activity of fig leaf (Ficus carica Linn.) extract against Enterococcus faecalis and its cytotoxicity effects on fibroblast cells. Vet World. 2018;11(3):342–7.
9. Ling WT, Liew FC, Lim WY, Subramaniam S, Chew BL. Shoot induction from axillary shoot tip explants of fig (Ficus carica) cv. japanese BTM 6. Trop Life Sci Res. 2018;29(2):165–74.
10. Zhang Y, Wan Y, Huo B, Li B, Jin Y, Hu X. Extracts and components of ficus carica leaves suppress survival, cell cycle, and migration of triple-negative breast cancer MDA-MB-231 cells. Onco Targets Ther. 2018;11:4377–86.
11. Pathania D, Sharma S, Singh P. Removal of methylene blue by adsorption onto activated carbon developed from Ficus carica bast. Arab J Chem [Internet]. 2017;10:S1445–51. Available from: http://dx.doi.org/10.1016/j.arabjc.2013.04.021
12. Shivaprasad H V., Rajaiah R, Frey BM, Frey FJ, Vishwanath BS. “Pergularain e I” - a plant cysteine protease with thrombin-like activity from Pergularia extensa latex. Thromb Res [Internet]. 2010;125(3):e100–5. Available from: http://dx.doi.org/10.1016/j.thromres.2009.10.002
13. Sheikh BY, Sarker MMR, Kamarudin MNA, Ismail A. Prophetic medicine as potential functional food elements in the intervention of cancer: A review. Biomed Pharmacother [Internet]. 2017;95(2017):614–48. Available from: https://doi.org/10.1016/j.biopha.2017.08.043
14. Comparin BC, Santos CHM dos, Dourado DM, Reichel PMG, Paola RS de, Pontes ERJC. Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extract. J Coloproctology [Internet]. 2018;38(4):283–9. Available from: http://dx.doi.org/10.1016/j.jcol.2018.05.009
15. Aldhebiani AY, Elbeshehy EKF, Baeshen AA, Elbeaino T. Inhibitory activity of different medicinal extracts from Thuja leaves, ginger roots, Harmal seeds and turmeric rhizomes against Fig leaf mottle-associated virus 1 (FLMaV-1) infecting figs in Mecca region. Saudi J Biol Sci [Internet]. 2017;24(4):936–44. Available from: http://dx.doi.org/10.1016/j.sjbs.2015.11.005
16. Veselská T, Kola?ík M. Fungal metabolic profile dataset was not influenced by long-term in vitro preservation of strains. Data Br. 2019;27.
17. Nugraha WF, Mulyani T. REVIEW ARTIKEL?: ETNOFARMAKOLOGI TANAMAN TIN (Ficus Carica L.) (KAJIAN TAFSIR ILMI TENTANG BUAH TIN DALAM AL-QUR’AN). 2020;VII(1):58–65.
18. Mijit M, HE Z, HONG J, LU M guang, LI S fang, ZHANG Z xiang. Analysis of fig tree virus type and distribution in China. J Integr Agric [Internet]. 2017;16(6):1417–21. Available from: http://dx.doi.org/10.1016/S2095-3119(16)61551-4
19. Raafat K, Wurglics M. Phytochemical analysis of Ficus carica L. active compounds possessing anticonvulsant activity. J Tradit Complement Med [Internet]. 2019;9(4):263–70. Available from: https://doi.org/10.1016/j.jtcme.2018.01.007
20. Yeganehzad S, Kiumarsi M, Nadali N, Rabie Ashkezary M. Formulation, development and characterization of a novel functional fruit snack based on fig (Ficus carica L.) coated with sugar-free chocolate. Heliyon [Internet]. 2020;6(7):e04350. Available from: https://doi.org/10.1016/j.heliyon.2020.e04350
21. Lu X, Wo G, Li B, Xu C, Wu J, Jiang C, et al. The anti-inflammatory NHE-06 restores antitumor immunity by targeting NF-?B/IL-6/STAT3 signaling in hepatocellular carcinoma. Biomed Pharmacother [Internet]. 2018;102(December 2017):420–7. Available from: https://doi.org/10.1016/j.biopha.2018.03.099
22. Turan A, Celik I. Antioxidant and hepatoprotective properties of dried fig against oxidative stress and hepatotoxicity in rats. Int J Biol Macromol [Internet]. 2016;91:554–9. Available from: http://dx.doi.org/10.1016/j.ijbiomac.2016.06.009
23. Zhang Y, Li Y, Ma P, Chen J, Xie W. Ficus carica leaves extract inhibited pancreatic ?-cell apoptosis by inhibiting AMPK/JNK/caspase-3 signaling pathway and antioxidation. Biomed Pharmacother [Internet]. 2020;122(November 2019):109689. Available from: https://doi.org/10.1016/j.biopha.2019.109689
24. Abbasi S, Kamalinejad M, Babaie D, Shams SM, Sadr Z, Gheysari M, et al. A new topical treatment of atopic dermatitis in pediatric patients based on Ficus carica L. (Fig): A randomized, placebo-controlled clinical trial. Complement Ther Med [Internet]. 2017;35(August 2017):85–91. Available from: http://dx.doi.org/10.1016/j.ctim.2017.10.003
25. Hedayat KM, Lapraz J-C. A general Endobiogenic approach to regulation of the immune system. The Theory of Endobiogeny. 2019;49–61.
26. Essid A, Aljane F, Ferchichi A. Morphological characterization and pollen evaluation of some Tunisian ex situ planted caprifig (Ficus carica L.) ecotypes. South African J Bot [Internet]. 2017;111:134–43. Available from: http://dx.doi.org/10.1016/j.sajb.2017.03.001
27. Hamed MB, El-Badry MO, Kandil EI, Borai IH, Fahmy AS. A contradictory action of procoagulant ficin by a fibrinolytic serine protease from Egyptian Ficus carica latex. Biotechnol Reports [Internet]. 2020;27:e00492. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2215017X20302988
28. Hald MM, Magnussen B, Appel L, Christensen JT, Hansen CH, Henriksen PS, et al. Fragments of meals in eastern Denmark from the Viking Age to the Renaissance: New evidence from organic remains in latrines. J Archaeol Sci Reports [Internet]. 2020;31(April):102361. Available from: https://doi.org/10.1016/j.jasrep.2020.102361
29. Ayoub L, Hassan F, Hamid S, Abdelhamid Z, Souad A. Phytochemical screening, antioxidant activity and inhibitory potential of Ficus carica and Olea europaea leaves. Bioinformation. 2019;15(3):226–32.
30. Bayoudh C, Elair M, Labidi R, Majdoub A, Mahfoudhi N, Mars M. Efficacy of tissue culture in virus elimination from caprifig and female fig varieties (Ficus carica L.). Plant Pathol J. 2017;33(3):288–95.
31. Mopuri R, Ganjayi M, Meriga B, Koorbanally NA, Islam MS. The effects of Ficus carica on the activity of enzymes related to metabolic syndrome. J Food Drug Anal [Internet]. 2018;26(1):201–10. Available from: https://doi.org/10.1016/j.jfda.2017.03.001
32. Mahjour M, Khoushabi A, Miri Ghale Novi M, Feyzabadi Z. Food strategies of renal atrophy based on Avicenna and conventional medicine. J Tradit Complement Med [Internet]. 2017;7(4):375–9. Available from: https://doi.org/10.1016/j.jtcme.2016.12.004
33. Ergül M, Ergül M, Eruygur N, Ata? M, Uçar E. In vitro evaluation of the chemical composition and various biological activities of ficus carica leaf extracts. Turkish J Pharm Sci. 2019;16(4):401–9.
34. Widyaningrum N, Hussana A, Adi RS, Tiastuti M, Utami KM, Kedokteran F, et al. Jurnal Farmasi Sains dan Praktis AKTIFITAS SITOTOKSIK KOMBINASI EKSTRAK BUAH TIN DAN MINYAK ZAITUN TERHADAP SEL KANKER PAYUDARA CYTOTOXIC ACTIVITY OF COMBINED FIG EXTRACT AND OLIVE OIL AGAINST BREAST CANCER CELLS. 2020;6(1):1–8.
35. Lazreg-Aref H, Gaaliche B, Ladhari A, Hammami M, Hammami SO. Co-evolution of enzyme activities and latex in fig (Ficus carica L.) during fruit maturity process. South African J Bot [Internet]. 2018;115:143–52. Available from: https://doi.org/10.1016/j.sajb.2018.01.022
36. Gaaliche B, Ladhari A, de Medeiros AG, Ben Mimoun M, Hajlaoui MR. Relationship between phytochemical profiles and phytotoxic proprieties of Tunisian fig leaf cultivars. South African J Bot [Internet]. 2017;112:322–8. Available from: http://dx.doi.org/10.1016/j.sajb.2017.06.015
37. Allegra A, Gallotta A, Carimi F, Mercati F, Inglese P, Martinelli F. Metabolic profiling and post-harvest behavior of “dottato” fig (Ficus carica L.) fruit covered with an edible coating from O. ficus-indica. Front Plant Sci. 2018;9(September):1–10.
38. Ahmed S, Hasan MM, Khan H, Mahmood ZA, Patel S. The mechanistic insight of polyphenols in calcium oxalate urolithiasis mitigation. Biomed Pharmacother [Internet]. 2018;106(July 2018):1292–9. Available from: https://doi.org/10.1016/j.biopha.2018.07.080
39. Mori K, Shirasawa K, Nogata H, Hirata C, Tashiro K, Habu T, et al. Corrigendum: Identification of RAN1 orthologue associated with sex determination through whole genome sequencing analysis in fig (Ficus carica L.) (Scientific Reports, (2017), 7, 1, (41124), 10.1038/srep41124). Sci Rep. 2017;7(1):1–3.
40. Nadeem M, Zeb A. Impact of maturity on phenolic composition and antioxidant activity of medicinally important leaves of Ficus carica L. Physiol Mol Biol Plants [Internet]. 2018;24(5):881–7. Available from: https://doi.org/10.1007/s12298-018-0550-3
41. Naghdi M, Maghbool M, Seifalah-Zade M, Mahaldashtian M, Makoolati Z, Kouhpayeh SA, et al. Effects of common fig (Ficus carica) leaf extracts on sperm parameters and testis of mice intoxicated with formaldehyde. Evidence-based Complement Altern Med. 2016;2016:18–20.
42. Agustina E. Uji Aktivitas Senyawa Antioksidan Dari Ekstrak Daun Tiin (Ficus carica Linn) dengan Pelarut Air, Metanol dan Campuran Metanol-Air. Klorofil. 2017;1(1):38–47.
43. Janghel V, Patel P, Chandel SS. Plants used for the treatment of icterus (jaundice) in Central India: A review. Ann Hepatol [Internet]. 2019;18(5):658–72. Available from: https://doi.org/10.1016/j.aohep.2019.05.003
44. Bouyahya A, Abrini J, Et-Touys A, Bakri Y, Dakka N. Indigenous knowledge of the use of medicinal plants in the North-West of Morocco and their biological activities. Eur J Integr Med [Internet]. 2017;13(March 2017):9–25. Available from: http://dx.doi.org/10.1016/j.eujim.2017.06.004
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Unduhan
Diterbitkan
2020-10-17
Cara Mengutip
ruslan, fadhilah nur azizah, & Makmun, A. . (2020). Beberapa Khasiat Buah Tin (Ficus Carica) Dari Antikonvulsan, Anti Alergik, Anti Inflamasi, Antihiperglikemik, Antitumor, Anti Kanker Hingga Terapi Hati. Baphomet University : Situs Slot Online Gacor Terbaik Hari Ini Server Thailand Gampang Maxwin 2024, 9(3), 184–201. https://doi.org/10.29303/jku.v9i3.409
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