Omega-3 Memiliki Banyak Manfaat: Apakah Bisa Melawan Kanker?
DOI:
https://doi.org/10.29303/jku.v12i2.951Abstract
Abstract: Cancer is the biggest cause of death in the world, around 10 million deaths are caused by cancer. In 2020, 17 million new cases were recorded, of which 8.5 million people died each year from cancer, while 66% of patients can live up to 5 years after being diagnosed and 40% of patients can live more than 10 years after being diagnosed. Various prevention efforts against risk factors have been carried out. The main modalities of cancer therapy today are surgery, chemotherapy, and radiation with the choice of therapy based on the stage of the cancer. Research shows that giving omega-3 supplementation to patients undergoing chemotherapy is considered very beneficial because omega-3 works synergistically with chemotherapeutic agents and can also be used to increase the radiosensitivity of tumor cells so that it has a good impact on the success of therapy.
References
Asl, E. R., Rostamzadeh, D., Duijf, P. H. G., Mafi, S.,
Mansoori, B., Barati, S., Cho, W. C., & Mansoori, B.
(2023). Mutant P53 in the formation and progression
of the tumor microenvironment: Friend or foe. Life
sciences, 315, 121361.
https://doi.org/10.1016/j.lfs.2022.121361.
Ayubi, N., Purwanto, B. and Rejeki, P. S. (2020) ‘Efek
Suplementasi Omega 3 dan Latihan Fisik Terhadap
Respon Inflamasi’, JOSSAE : Journal of Sport Science
and Education, 5(2), p. 116. doi:
26740/jossae.v5n2.p116-123.
Borek, C. (2017) ‘Dietary Antioxidants and Human
Cancer’, Journal of Restorative Medicine, 6(1), pp. 53–61.
doi: 10.14200/jrm.2017.6.0105.
Budhy, T. I., 2019. Mengapa Terjadi Kanker. 2nd ed.
Surabaya: Airlangga University Press.
Caruso, G. et al. (2020) ‘Fishery Wastes as a Yet
Undiscovered Treasure from the Sea: Biomolecules
Sources, Extraction Methods and Valorization’,
Marine Drugs, 18(12). doi: 10.3390/md18120622.
Cheng, M., Zhang, S., Ning, C., & Huo, Q. (2021).
Omega-3 Fatty Acids Supplementation Improve
Nutritional Status and Inflammatory Response in
Patients With Lung Cancer: A Randomized Clinical
Jurnal Kedokteran Unram June 2023, 12 (2), 217 – 221
Trial. Frontiers in nutrition, 8, 686752.
https://doi.org/10.3389/fnut.2021.686752.
Dempsey, M., Rockwell, M. S., & Wentz, L. M. (2023).
The influence of dietary and supplemental omega-3
fatty acids on the omega-3 index: A scoping
review. Frontiers in
Nutrition, 10. https://doi.org/10.3389/fnut.2023.107
Figueiredo, A. R. P. et al. (2019) ‘The Effects of Different
Extraction Methods of Lipids from Nannochloropsis
oceanica on The Contents of Omega-3 Fatty Acids’,
Algal Research, 41(December 2018), p. 101556. doi:
1016/j.algal.2019.101556.
Freitas, R. D. S. and Campos, M. M. (2019) ‘Protective
Effects of Omega-3 Fatty Acids in Cancer-Related
Complications’, Nutrients, pp. 1–23.
Gellrich, N. C. et al. (2015) ‘Oral cancer malnutrition
impacts weight and quality of life’, Nutrients, 7(4), pp.
–2160. doi: 10.3390/nu7042145.
Gutiérrez, S., Svahn, S. L. and Johansson, M. E. (2019)
‘Effects of Omega-3 Fatty Acids on Immune Cells’,
International Journal of Molecular Sciences, 20(20).
doi: 10.3390/ijms20205028.
Hausman, D.M. (2019). What Is Cancer?Perspectives in
Biology and Medicine 62(4), 778-784.
doi:10.1353/pbm.2019.0046.
Huerta-Yépez, S., Tirado-Rodriguez, A. B. and
Hankinson, O. (2016) ‘Papel de las dietas ricas en
omega-3 y omega-6 en el desarrollo del cáncer’,
Boletin Medico del Hospital Infantil de Mexico, 73(6), pp.
–456. doi: 10.1016/j.bmhimx.2016.11.001.
Innis, S. M. (2014). Omega-3 Fatty Acid Biochemistry:
Perspectives from Human Nutrition. Military
Medicine, 179(11S), 82–
https://doi.org/10.7205/milmed-d-14-00147
Klek S. (2016). Omega-3 Fatty Acids in Modern
Parenteral Nutrition: A Review of the Current
Evidence. Journal of clinical medicine, 5(3), 34.
https://doi.org/10.3390/jcm5030034.
Lavy, M. et al. (2021) ‘Specialized Pro-Resolving
Mediators Mitigate Cancer-Related Inflammation:
Role of Tumor-Associated Macrophages and
Therapeutic Opportunities’, Frontiers in Immunology,
(June), pp. 1–19. doi: 10.3389/fimmu.2021.702785.
Leuzzi, G. et al. (2016) ‘Baseline C-reactive protein level
predicts survival of early-stage lung cancer: Evidence
from a systematic review and meta-analysis’, Tumori,
(5), pp. 441–449. doi: 10.5301/tj.5000522.
Mansara, P. et al. (2015) ‘Improved antioxidant status by
omega-3 fatty acid supplementation in breast cancer
patients undergoing chemotherapy: A case series’,
Journal of Medical Case Reports, 9(1), pp. 1–6. doi:
1186/s13256-015-0619-3.
Melgosa, R., Sanz, M. T. and Beltrán, S. (2021)
‘Supercritical CO2 Processing of Omega-3
Polyunsaturated Fatty Acids – Towards a Biorefinery
for Fish Waste Valorization’, Journal of Supercritical
Fluids, 169. doi: 10.1016/j.supflu.2020.105121.
Muscaritoli, M. et al. (2021) ‘ESPEN practical guideline:
Clinical Nutrition in cancer’, Clinical Nutrition, 40(5),
pp. 2898–2913. doi: 10.1016/j.clnu.2021.02.005.
Paixão, E. M. D. S. et al. (2017) ‘The effects of EPA and
DHA enriched fish oil on nutritional and
immunological markers of treatment naïve breast
cancer patients: A randomized double-blind
controlled trial’, Nutrition Journal, 16(1), pp. 1–11. doi:
1186/s12937-017-0295-9.
Qi, X. et al. (2022) ‘Antioxidants in brain tumors: current
therapeutic significance and future prospects’,
Molecular Cancer, 21(1), pp. 1–32. doi: 10.1186/s12943-
-01668-9.
Robbins, O. (2021). Omega-3s: Why Are They Important
— And What Are the Best Sources for Your Health?
(Updated August 17, 2021). Akses gambar pada:
https://foodrevolution.org/blog/omega-3s-vegan/
Samanta, C. et al. (2022) ‘Omega-3 Fatty Acid and its
Protective Effect against Cancer and Cancer-related
Complication’, Journal of Pharmaceutical Research
International, 34, pp. 51–62. doi:
9734/jpri/2022/v34i18a35785.
Santos, H. O., May, T. L., & Bueno, A. A. (2023). Eating
more sardines instead of fish oil supplementation:
Beyond omega-3 polyunsaturated fatty acids, a
matrix of nutrients with cardiovascular
benefits. Frontiers in
Nutrition, 10. https://doi.org/10.3389/fnut.2023.110
Sari, L. M. (2018) ‘Apoptosis: Mekanisme Molekuler
Kematian Sel’, Cakradonya Dental Journal, 10(2), pp.
–70. doi: 10.24815/cdj.v10i2.11701.
Sun SN, Jia WD, Chen H, Ma JL, Ge YS, Yu JH, Li JS.
Docosahexaenoic acid (DHA) induces apoptosis in
human hepatocellular carcinoma cells. International
Journal of Clinical and Experimental Pathology.
;6(2):281.
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M.,
Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global
Cancer Statistics 2020: GLOBOCAN Estimates of
Incidence and Mortality Worldwide for 36 Cancers in
Countries. CA: a cancer journal for clinicians, 71(3),
–249. https://doi.org/10.3322/caac.21660
Tantipaiboonwong, P. et al. (2021) ‘Molecular
mechanism of antioxidant and anti-inflammatory
effects of omega-3 fatty acids in perilla seed oil and
rosmarinic acid rich fraction extracted from perilla
seed meal on TNF-α induced A549 lung
adenocarcinoma cells’, Molecules, 26(22). doi:
3390/molecules26226757.
Tao, X., Zhou, Q., & Rao, Z. (2022). Efficacy of ω-3
Polyunsaturated Fatty Acids in Patients with Lung
Jurnal Kedokteran Unram June 2023, 12 (2), 217 – 221
Cancer Undergoing Radiotherapy and
Chemotherapy: A Meta-Analysis. International
Journal of Clinical Practice, 2022, 1–
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