Pathophysiological Aspects of Tuberculous Meningitis and Tuberculom


  • Putu Wika Pramesti Iswari
  • Ni Putu Visty Widhiani Faculty of Medicine, Mataram University, Indonesia
  • Shalsa Damai Akelba Faculty of Medicine, Mataram University, Indonesia
  • Tri Sastra Pradhini Faculty of Medicine, Mataram University, Indonesia
  • Herpan Syafii Harahap Department of Neurology, Faculty of Medicine, University of Mataram, Mataram, Indonesia
  • Safat Wahyudi Department of Neurology, Faculty of Medicine, University of Mataram, Mataram, Indonesia
  • Stephanie Elizabeth Gunawan Department of Neurology, Faculty of Medicine, University of Mataram, Mataram, Indonesia



Pathophysiology, Tuberculosis, Meningitis


In the world, tuberculosis (TB) remains to be a health issue. Although its spread can be stopped, tuberculosis is an infectious disease with a high fatality rate. TB can result in a variety of side effects, among them TB meningitis. The mechanism for the spread of TB bacteria through blood vessels to other organs is influenced by the immune system. TB bacteria use the "Trojan horse" mechanism to enter the blood-brain barrier (BBB). In the central nervous system, there is immune activity that will fight TB bacteria and form tuberculoma, or rich foci. If this rich focus ruptures, TB bacteria will be released into the subarachnoid space or ventricular system, causing TB meningitis.


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How to Cite

Iswari, P. W. P. ., Ni Putu Visty Widhiani, Shalsa Damai Akelba, Tri Sastra Pradhini, Herpan Syafii Harahap, Safat Wahyudi, & Stephanie Elizabeth Gunawan. (2023). Pathophysiological Aspects of Tuberculous Meningitis and Tuberculom. Jurnal Kedokteran, 12(3), 262–268.

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