Korelasi antara Kadar Asam Urat Serum dan Probabilitas Stroke Iskemik pada Penduduk di Kecamatan Sekarbela Mataram
DOI:
https://doi.org/10.29303/jku.v6i3.1.263Keywords:
kadar asam urat serum, stroke iskemik, Framingham stroke risk scoreAbstract
Latar Belakang: Stroke merupakan salah satu penyebab utama kematian yang dapat dicegah. Probabilitas stroke iskemik dapat diukur dengan menggunakan penilaian skor risiko stroke menurut Framingham. Korelasi antara kadar asam urat serum dengan probabilitas stroke iskemik hingga kini menjadi kontroversi. Tujuan penelitian ini untuk mengetahui kadar asam urat serum, probabilitas stroke iskemik dan hubungan antara kadar asam urat serum dan probabilitas stroke iskemik pada penduduk di Kecamatan Sekarbela Mataram.
Metode Penelitian: Penelitian ini merupakan penelitian deskriptif analitik dengan desain potong lintang dan melibatkan 59 orang penduduk di Kecamatan Sekarbela Mataram. Data yang diperiksa meliputi usia, kadar asam urat serum, penyakit kardiovaskular, diabetes mellitus, terapi anti hipertensi, fibrilasi atrium, hipertrofi ventrikel kiri, tekanan darah sistolik dan merokok.
Hasil: Hasil uji korelasi yang dilakukan menunjukkan bahwa tidak terdapat hubungan yang signifikan antara kadar asam urat serum dan probabilitas stroke iskemik pada penduduk di Kecamatan Sekarbela Mataram (p=0,167).
Kesimpulan: Tidak terdapat hubungan yang signifikan antara kadar asam urat serum dan probabilitas stroke iskemik pada penduduk di Kecamatan Sekarbela Mataram.
References
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14. Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells.Journal of the American Society of Nephrology. 2005. 16(12):3553-62.
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17. Qin LV, Xian-Fang,M, Fang-Fang H, Shan C, Hua S, Jing X. High Serum Uric Acid and Increased Risk of Type 2 Diabetes: A Systemic Review and Meta-Analysis ofProspective Cohort Studies. Plos ONE. 2013 8(2): 1-7.
18. Dahlan MS. Besar Sampel dan Cara Pengambilan Sampel dalam Penelitian Kedokteran dan Kesehatan. Edisi 3. Jakarta: Salemba Medika; 2013. p.35-80
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20. Heinig M and RJ Johnson. Role of Uric Acid in Hypertension, RenalDisease, and Metabolic Syndrome. Cleveland Clinic Journal of Medicine. 2006:11:1059-64.
21. Tousoulis D, Kampoli AM, Tentolouris C, Papageorgiou N, Stefanadis C.The role of nitric oxide on endothelial function. Journal Impacting Vascular Pharmacology.2012;10(1):4-18.
22. Koppula L, Kaul S, Rao AV, Jyothy A, Munshi A. Association of serum uric acid level with ischemic stroke, stroke subtypes and clinical outcome. Neurology Asia. 2013; 18(4) : 349 – 353.
23. Prasad C, Dwivedi NC, Gupta P, Shukla SK, Shukla R., Yadav RK. Serum Uric Acid Level in Patients of Acute Stroke. International Journal of Advances in Medicine. 2016 May;3(2):393-397.
2. Price SA and Wilson LM. Patofisiologi: Konsep Klinis Proses-Proses penyakit. Vol 2. Edisi 6. Jakarta: EGC. 2013.
3. Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan Republik Indonesia (Badan Litabangkes). Riset Kesehatan Dasar 2013. Jakarta: Bakti Husada. 2013.
4. Mozaffarian D, Benjamin EJ, Go AS, Amett DK, Blaha MJ, Cushman, M, et al. Heart disease and stroke statistics-2015 update : A report from the American Heart Association. American Heart Association Journal. 2015;131:e29-e322.
5. Yudiarto F, Machfoed M, Darwin A, Ong A, Karyana M, Siswanto. Indonesia Stroke Registry. The Official Journal of the American Academy of Neurology. 2014;81(10).
6. Goldstein LB, Bushnell CD, Adams RJ, Appel LJ, Braun LT, Chaturvedi S,et al. Guidelines for the primary prevention of stroke: A Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association. American Heart Association Journal; 2011;42:517–584.
7. Meschia JF, Bushnell C, Albala BB, Braun LT, Bravata DM, Chaturvedi S, et al. Guidelines for the primary prevention of stroke: A statement for healthcare professionals from the American heart association/American stroke association. American Heart Association Journal; 2014;45:1-10.
8. Wolf PA, D’Agostino RB, Belanger RJ, Kannel WB. Probability of stroke: a risk profile from the Framingham Study. American Heart Association Journal. 1991. 22:312-318.
9. Bos MJ, Koudstall PJ, Hofman A, Witteman JC, Breteler MM. Uric Acid Is a Risk Factor for Myocardial Infarction The Rotterdam Study.American Heart Association Journal. 2006;37:1503-1507.
10. Dawson J & Walters M. Uric acid and xanthine oxidase: Future therapeutic targets in the prevention of cardiovascular disease? British Journal of Clinical Pharmacology, 2006;62(6), pp.633–64.
11. Storhaug HM, Norvik JV, Toft I, Eriksen BO, Løchen ML, Zykova S, et al. Uric Acid is a Risk Factor for Ischemic Stroke and All-Cause Mortality in the General Population: a Gender Specific Analysis from the Thomso Study. Bio Med Central Cardiovascular Disorders. 2013; 13:115
12. Iranmanesh F, Sheykholeslami NZ, Gadari F, Ahmady J. Acute ischemic non-embolic stroke andserum level of uric acid. Iranian Journalof Neurology2012; 11(1): 1-5.
13. Mehrpour M, Khuzan M, Najimi N, Motamed, MR, Fereshtehnejad SM. Serum Uric Acid Level in Acute Stroke Patients. Iran: Iran University of Medical Science. Medical Journal of Islamic Republic of Iran; 2012 ;26(2):66-72.
14. Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells.Journal of the American Society of Nephrology. 2005. 16(12):3553-62.
15. Shankar A, Klein R, Klein BE, Nieto FJ. The association between serum uric acid level and long-term incidence of hypertension: Population-based cohort study. Journal of Human Hypertersion. 2006. 20(12):937-45.
16. Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovascular risk. The New England Journal of Medicine. 2009. 359(17):1811-1821.
17. Qin LV, Xian-Fang,M, Fang-Fang H, Shan C, Hua S, Jing X. High Serum Uric Acid and Increased Risk of Type 2 Diabetes: A Systemic Review and Meta-Analysis ofProspective Cohort Studies. Plos ONE. 2013 8(2): 1-7.
18. Dahlan MS. Besar Sampel dan Cara Pengambilan Sampel dalam Penelitian Kedokteran dan Kesehatan. Edisi 3. Jakarta: Salemba Medika; 2013. p.35-80
19. Johnson RJ, Kang DH, Feig DI, Kivlighn S, Kanelis J, Watanabe S, et al. Is There a Pathogenic Rule of Uric Acid in Hypertension, Cardiovascular and Renal Disease? Hypertension Journal. 2003:22(3):1183-90.
20. Heinig M and RJ Johnson. Role of Uric Acid in Hypertension, RenalDisease, and Metabolic Syndrome. Cleveland Clinic Journal of Medicine. 2006:11:1059-64.
21. Tousoulis D, Kampoli AM, Tentolouris C, Papageorgiou N, Stefanadis C.The role of nitric oxide on endothelial function. Journal Impacting Vascular Pharmacology.2012;10(1):4-18.
22. Koppula L, Kaul S, Rao AV, Jyothy A, Munshi A. Association of serum uric acid level with ischemic stroke, stroke subtypes and clinical outcome. Neurology Asia. 2013; 18(4) : 349 – 353.
23. Prasad C, Dwivedi NC, Gupta P, Shukla SK, Shukla R., Yadav RK. Serum Uric Acid Level in Patients of Acute Stroke. International Journal of Advances in Medicine. 2016 May;3(2):393-397.
Published
2018-12-14
How to Cite
Cahyadi, A., Harahap, H. S., & Padauleng, N. (2018). Korelasi antara Kadar Asam Urat Serum dan Probabilitas Stroke Iskemik pada Penduduk di Kecamatan Sekarbela Mataram. Jurnal Kedokteran, 6(3.1). https://doi.org/10.29303/jku.v6i3.1.263
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Section
Research
