Effectiveness of Betahistine in the Management of Vertigo

Authors

  • Ath-Thariq Ramadhan Fakultas Kedokteran Universitas Mataram
  • Ilsa Hunaifi Bagian Neurologi Fakultas Kedokteran Universitas Mataram/RSUD Propinsi NTB

DOI:

https://doi.org/10.29303/jku.v11i4.812

Keywords:

Vertigo, Treatment, Betahistine

Abstract

Vertigo is an illusion of self-movement or environmental movement. This symptom produces some sensation of disorientation in space and is accompanied by vegetative disturbances (nausea, vomiting, sweating) or auditory symptoms (hearing loss, tinnitus, ear fullness). Benign paroxysmal positional vertigo (BPPV), Ménière's disease, and vestibular neuritis are common cases in clinical practice. Treatment of vertigo usually includes the use of medication, physical therapy, and lifestyle adaptations. The most commonly used pharmacological modality is betahistine for the treatment of Ménière's disease and BPPV. Betahistine has activity modulating the histaminergic system, causing vasodilation and improving blood flow to the cochlea, thereby improving vertigo symptoms.

References

1. Dommaraju S, Perera E. An approach to vertigo in general practice. Aust Fam Physician. 2016;45(4):190–4.
2. Labuguen RH. Initial evaluation of vertigo. Am Fam Physician. 2006;73(11–12):585–90.
3. Nur anggraini D, Wurllete WE, Permana WE. Menganalisis Dampak Penggunaan Betahistine Mesilate Terhadap Pasien Gejala Vertigo Perifer Di Klinik Al Ma’soem Cibulareng. J Sos Sains. 2021;1(10):1315–25.
4. Thursina C, Dewati E. Pedoman Tatalaksana Vertigo. Edisi kedu. Jakarta; 2017.
5. Ramos Alcocer R, Ledezma Rodríguez JG, Navas Romero A, Cardenas Nuñez JL, Rodríguez Montoya V, Deschamps J, et al. Use of betahistine in the treatment of peripheral vertigo. Acta Otolaryngol. 2015;135(12):1205–11.
6. Murdin L, Hussain K, Schilder AGM. Betahistine for symptoms of vertigo. Cochrane Database Syst Rev. 2016;2013(8).
7. Pinzon RT, Sanyasi RDLR. Betahistine as a treatment for vertigo: A systematic review of randomized controlled trial. Asian J Pharm Pharmacol. 2018;4(1):6–12.
8. Indriawati KR, Pinzon RT. Dampak Penggunaan Betahistin Mesilate Terhadap Perbaikan Gejala Vertigo Perifer Di Rumah Sakit Bethesda Yogyakarta. Berk Ilm Kedokt Duta Wacana. 2017;2(3):427.
9. Sokolova L, Hoerr R, Mishchenko T. Treatment of Vertigo: A Randomized, Double-Blind Trial Comparing Efficacy and Safety of Ginkgo biloba Extract EGb 761 and Betahistine . Int J Otolaryngol. 2014;2014:1–6.
10. Motamed H, Moezzi M, Rooyfard AD, Angali KA, Izadi Z. A Comparison of the Effects and Side Effects of Oral Betahistine with Injectable Promethazine in the Treatment of Acute Peripheral Vertigo in Emergency. J Clin Med Res. 2017;9(12):994–7.
11. Al?tamimi DJ, Ammoo AM, Alani ME, Ibraheem JJ. Pharmacokinetics and dose proportionality of betahistine in healthy individuals. Sci Pharm. 2020;88(1).
12. Lacour M. Betahistine treatment in managing vertigo and improving vestibular compensation: Clarification. J Vestib Res Equilib Orientat. 2013;23(3):139–51.
13. Biswas A, Dutta N. Role of Betahistine in the Management of Vertigo. Ann Otol Neurotol. 2018;01(02):051–7.
14. Parfenov VA, Golyk VA, Matsnev EI, Morozova S V., Melnikov OA, Antonenko LM, et al. Effectiveness of betahistine (48 mg/day) in patients with vestibular vertigo during routine practice: The VIRTUOSO study. PLoS One. 2017;12(3):1–11.
15. Benecke H, Pérez-Garrigues H, Bin Sidek D, Uloziene I, Kuessner D, Sondag E, et al. Effects of betahistine on patient-reported outcomes in routine practice in patients with vestibular vertigo and appraisal of tolerability: Experience in the OSVaLD study. Int Tinnitus J. 2010;16(1):14–24.

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Published

2022-12-30

How to Cite

Ramadhan, A.-T., & Hunaifi, I. (2022). Effectiveness of Betahistine in the Management of Vertigo. Jurnal Kedokteran, 11(4), 1177–1182. https://doi.org/10.29303/jku.v11i4.812

Issue

Section

Literature Review