HUBUNGAN ANTARA GAMBARAN HISTOPATOLOGI DENGAN JUMLAH LEUKOSIT PADA PENDERITA LIMFADENITIS TUBERKULOSIS DI NUSA TENGGARA BARAT TAHUN 2019
DOI:
https://doi.org/10.29303/jku.v10i1.453Kata Kunci:
Limfadenitis tuberkulosis, gambaran histopatologi, well organized granuloma, poorly organized granuloma, jumlah leukosit, respon imunAbstrak
Latar Belakang: Indonesia merupakan negara ke-3 dengan insidensi Tuberkulosis (TB) terbanyak di dunia. 15% kasus TB merupakan Extra Pulmonary TB (EPTB) dengan 50% kasus diantaranya merupakan Limfadenitis TB (LNTB). Gambaran histopatologi dari sampel biopsi yang diambil dari limfonodi terdampak memegang peran penting dalam diagnosis penyakit ini dengan mengasilkan gambaran Well Organized Granuloma (WOG) atau Poorly Organized Granuloma (POG). Jumlah leukosit dapat menggambarkan respon imun pada penderita LNTB.
Metode : Penelitian ini merupakan penelitian analitik observasional dengan metode pendekatan potong lintang. Data diperoleh dengan melakukan dokumentasi rekam medis pasien LNTB yang dirawat di Rumah Sakit Umum Daerah (RSUD) Provinsi NTB dan RSUD Kota Mataram dalan rentang waktu Januari tahun 2019 – Februari tahun 2020.
Hasil : Total subjek penelitian berjumlah 51 orang. Pada gambaran histopatologi, 37 sampel termasuk WOG dan 14 sampel termasuk POG. Pada jumlah leukosit, tidak ada pasien yang mengalami leukopenia, 39 pasien mempunyai jumlah leukosit yang normal dan 12 pasien mengalami leukositosis. Hasil dari uji korelasi Spearman didapatkan p = 0.005 dan r = 0.384
Kesimpulan : Terdapat hubungan yang bermakna antara gambaran histopatologi dengan jumlah leukosit pada penderita LNTB di NTB pada Januari 2019 – Februari 2020. Korelasi tersebut bersifat lemah.
Referensi
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18. Miranda MS, Breiman A, Allain S, Deknuydt F, Altare F. The tuberculous granuloma: An unsuccessful host defence mechanism providing a safety shelter for the bacteria? Clin Dev Immunol. 2012;2012.
19. Prezzemolo T, Guggino G, La Manna MP, Di Liberto D Di, Dieli F, Caccamo N. Functional signatures of human CD4 and CD8 T cell responses to Mycobacterium tuberculosis. Front Immunol. 2014;5(180):1–13.
20. Volkman HE, Clay H, Beery D, Chang JCW, Sherman DR, Ramakrishnan L. Tuberculous granuloma formation is enhanced by a Mycobacterium virulence determinant. PLoS Biol. 2004;2(11).
21. Patterson KC, Queval CJ, Gutierrez MG. Granulomatous Inflammation in Tuberculosis and Sarcoidosis: Does the Lymphatic System Contribute to Disease? BioEssays. 2019;41(11):1–8.
22. Wang J, Yin Y, Wang X, Pei H, Kuai S, Gu L, et al. Ratio of monocytes to lymphocytes in peripheral blood in patients diagnosed with active tuberculosis. Brazilian J Infect Dis [Internet]. 2015;19(2):125–31. Available from: http://dx.doi.org/10.1016/j.bjid.2014.10.008
23. Rees CA, Pineros DB, Amour M, Munseri P, Said J, Magohe A, et al. The potential of CBC-derived ratios (monocyte-to-lymphocyte, neutrophil-to-lymphocyte, and platelet-to-lymphocyte) to predict or diagnose incident TB infection in Tanzanian adolescents. BMC Infect Dis. 2020;20(1):1–10.
24. Iliaz S, Iliaz R, Ortakoylu G, Bahadir A, Bagci BA, Caglar E. Value of neutrophil/lymphocyte ratio in the differential diagnosis of sarcoidosis and tuberculosis. Ann Thorac Med. 2014;9(4):232–5.
25. Özdemir C, Sökücü SN, Önür ST. Can neutrophil/lymphocyte ratio and platelet/lymphocyte ratio be used in differential diagnosis of Stage I sarcoidosis from tuberculosis lymphadenopathy? Eurasian J Pulmonol. 2018;20(1).
26. Ayed H Ben, Koubaa M, Marrakchi C, Rekik K, Jemaa T Ben, Jemaa M Ben, et al. Could neutrophil to lymphocyte ratio be a prognostic predictor of relapse in patients with extra-pulmonary tuberculosis? Electron J Gen Med. 2018;15(4).
27. Rahman EY, Tjokrosonto S. Hubungan antara ekspresi CD4+ dan CD8+ dengan gambaran histopatologis dan gambaran klinis pada pasien limfadenitis tuberkulosis [Internet]. Universitas Gajah Mada; 2004. Available from: http://etd.repository.ugm.ac.id/home/detail_pencarian/24389
28. Silva AA, Mauad T, Saldiva PHN, Pires-Neto RC, Coletta RD, Graner E, et al. Immunophenotype of lung granulomas in HIV and non-HIV associated tuberculosis. Med Express. 2014;1(4).
29. Eliandy S, Lubis MND. Hubungan Gambaran Bercak-Bercak Gelap ( Dark Specks ) pada Latar Belakang Material Nekrotik Granular Eosinofilik dengan Kadar CD4 Penderita Limfadenitis Tuberkulosis Servikalis yang Disertai HIV / AIDS. Maj Patol. 20(3):8–14.
30. Rao JS, Kumari J, Kini U. Correlation of CD4 Counts with the FNAC Patterns of Tubercular Lymphadenitis in Patients with HIV: A Cross Sectional Pilot Study. Diagn Cytopathol. 2014;43(1):16–20.
2. Kartasasmita CB. Epidemiologi Tuberkulosis. Sari Pediatr [Internet]. 2009;11(2). Available from: https://saripediatri.org/index.php/sari-pediatri/article/view/605
3. Wahid F, Rehman H, Ahmad I. Extrapulmonary tuberculosis in patients with cervical lymphadenopathy. J Pak Med Assoc [Internet]. 2013;63(9):1094–7. Available from: https://jpma.org.pk/article-details/4623?article_id=4623
4. Ahmed HGE, Nassar AS, Ginawi I. Screening for Tuberculosis and Its Histological Pattern in Patients with Enlarged Lymph Node. Patholog Res Int. 2011;2011:417635.
5. Goldszmid RS, Dzutsev A, Trinchieri G. Host immune response to infection and cancer: unexpected commonalities. Cell Host Microbe. 2015;15(3):295–305.
6. Chaplin DD. Overview of the Immune Response. J Allergy Clin Immunol. 2010;125(2):S3-23.
7. Kumar V, Abbas AK, Aster JC. Robbins Basic Pathology. 9th ed. Philadelphia: Elsevier Inc.; 2013.
8. Hong LF, Li XL, Luo SH, Guo YL, Liu J, Zhu CG, et al. Relation of leukocytes and its subsets counts with the severity of stable coronary artery disease in patients with diabetic mellitus. PLoS One. 2014;9(3):1–7.
9. Chmielewski PP, Strzelec B. Elevated leukocyte count as a harbinger of systemic inflammation, disease progression, and poor prognosis: A review. Folia Morphol. 2018;77(2):171–8.
10. Dragu R, Huri S, Zuckerman R, Suleiman M, Mutlak D, Agmon Y, et al. Predictive value of white blood cell subtypes for long-term outcome following myocardial infarction. Atherosclerosis. 2008;196(1):405–12.
11. Ramakrishnan L. Revisiting the role of the granuloma in tuberculosis. Nat Rev Immunol [Internet]. 2012;12(5):352–66. Available from: http://dx.doi.org/10.1038/nri3211
12. Ehlers S, Schaible UE. The granuloma in tuberculosis: Dynamics of a host-pathogen collusion. Front Immunol. 2012;3:1–9.
13. Pagán AJ, Ramakrishnan L. The Formation and Function of Granulomas. Annu Rev Immunol. 2018;36(13:7):639–65.
14. Petersen HJ, Smith AM. The Role of the Innate Immune System in Granulomatous Disorders. Front Immunol. 2013;4(May):1–11.
15. Hines ME, Kreeger JM, Herron AJ. Mycobacterial Infecions of Animals?: Pathology and Pathogenesis. Lab Anim Sci. 1995;45(4):334–51.
16. Martinot AJ. Microbial Offense vs Host Defense: Who Controls the TB Granuloma? Vet Pathol. 2018;55(1):14–26.
17. Flynn JL, Chan J, Lin PL. Macrophages and control of granulomatous inflammation in tuberculosis. Mucosal Immunol [Internet]. 2011;4(3):271–8. Available from: http://dx.doi.org/10.1038/mi.2011.14
18. Miranda MS, Breiman A, Allain S, Deknuydt F, Altare F. The tuberculous granuloma: An unsuccessful host defence mechanism providing a safety shelter for the bacteria? Clin Dev Immunol. 2012;2012.
19. Prezzemolo T, Guggino G, La Manna MP, Di Liberto D Di, Dieli F, Caccamo N. Functional signatures of human CD4 and CD8 T cell responses to Mycobacterium tuberculosis. Front Immunol. 2014;5(180):1–13.
20. Volkman HE, Clay H, Beery D, Chang JCW, Sherman DR, Ramakrishnan L. Tuberculous granuloma formation is enhanced by a Mycobacterium virulence determinant. PLoS Biol. 2004;2(11).
21. Patterson KC, Queval CJ, Gutierrez MG. Granulomatous Inflammation in Tuberculosis and Sarcoidosis: Does the Lymphatic System Contribute to Disease? BioEssays. 2019;41(11):1–8.
22. Wang J, Yin Y, Wang X, Pei H, Kuai S, Gu L, et al. Ratio of monocytes to lymphocytes in peripheral blood in patients diagnosed with active tuberculosis. Brazilian J Infect Dis [Internet]. 2015;19(2):125–31. Available from: http://dx.doi.org/10.1016/j.bjid.2014.10.008
23. Rees CA, Pineros DB, Amour M, Munseri P, Said J, Magohe A, et al. The potential of CBC-derived ratios (monocyte-to-lymphocyte, neutrophil-to-lymphocyte, and platelet-to-lymphocyte) to predict or diagnose incident TB infection in Tanzanian adolescents. BMC Infect Dis. 2020;20(1):1–10.
24. Iliaz S, Iliaz R, Ortakoylu G, Bahadir A, Bagci BA, Caglar E. Value of neutrophil/lymphocyte ratio in the differential diagnosis of sarcoidosis and tuberculosis. Ann Thorac Med. 2014;9(4):232–5.
25. Özdemir C, Sökücü SN, Önür ST. Can neutrophil/lymphocyte ratio and platelet/lymphocyte ratio be used in differential diagnosis of Stage I sarcoidosis from tuberculosis lymphadenopathy? Eurasian J Pulmonol. 2018;20(1).
26. Ayed H Ben, Koubaa M, Marrakchi C, Rekik K, Jemaa T Ben, Jemaa M Ben, et al. Could neutrophil to lymphocyte ratio be a prognostic predictor of relapse in patients with extra-pulmonary tuberculosis? Electron J Gen Med. 2018;15(4).
27. Rahman EY, Tjokrosonto S. Hubungan antara ekspresi CD4+ dan CD8+ dengan gambaran histopatologis dan gambaran klinis pada pasien limfadenitis tuberkulosis [Internet]. Universitas Gajah Mada; 2004. Available from: http://etd.repository.ugm.ac.id/home/detail_pencarian/24389
28. Silva AA, Mauad T, Saldiva PHN, Pires-Neto RC, Coletta RD, Graner E, et al. Immunophenotype of lung granulomas in HIV and non-HIV associated tuberculosis. Med Express. 2014;1(4).
29. Eliandy S, Lubis MND. Hubungan Gambaran Bercak-Bercak Gelap ( Dark Specks ) pada Latar Belakang Material Nekrotik Granular Eosinofilik dengan Kadar CD4 Penderita Limfadenitis Tuberkulosis Servikalis yang Disertai HIV / AIDS. Maj Patol. 20(3):8–14.
30. Rao JS, Kumari J, Kini U. Correlation of CD4 Counts with the FNAC Patterns of Tubercular Lymphadenitis in Patients with HIV: A Cross Sectional Pilot Study. Diagn Cytopathol. 2014;43(1):16–20.
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Diterbitkan
2021-04-04
Cara Mengutip
Alfaridzi, M., Lestarini, I. A., & Djannah, F. . (2021). HUBUNGAN ANTARA GAMBARAN HISTOPATOLOGI DENGAN JUMLAH LEUKOSIT PADA PENDERITA LIMFADENITIS TUBERKULOSIS DI NUSA TENGGARA BARAT TAHUN 2019. Baphomet University : Situs Slot Online Gacor Terbaik Hari Ini Server Thailand Gampang Maxwin 2024, 10(1), 405–412. https://doi.org/10.29303/jku.v10i1.453
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