The Neuroprotective Role of Cognitive Reserve Against Type 2 Diabetes Mellitus-associated Cognitive Impairment




type 2 diabetes mellitus, glycemic control, insulin resistance, cognitive reserve, functional activity


Cognitive impairment is one of the important complications of type 2 diabetes mellitus. Type 2 diabetes mellitus-associated cognitive impairment has wide spectrum, ranging from mild cognitive impairment to dementia. The susceptibility of patients with type 2 diabetes mellitus to experiencing cognitive impairment is also determined by their previous cognitive reserve status. A good cognitive reserve of a patient with type 2 diabetes mellitus will protect him from cognitive impairment. The components of cognitive reserve, including education, occupation, hobbies, and social and physical activities provide a protective effect through neural reserve and neural compensation mechanisms that lead to a serial processes of neurogenesis, production of neurotropic factors, and neurotransmitter regulation. An understanding of the neuroprotective effects of the components of cognitive reserve is very important in determining optimal cognitive impairment management strategies in type 2 diabetes mellitus patients, in such a way that they are still able to carry out daily functional activities properly.

Author Biography

Herpan Syafii Harahap, Department of Neurology, Faculty of Medicine, Universitas Mataram

Department of Neurology


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How to Cite

Harahap, H. S., & Indrayana, Y. (2021). The Neuroprotective Role of Cognitive Reserve Against Type 2 Diabetes Mellitus-associated Cognitive Impairment. Jurnal Kedokteran, 9(4), 256–263.



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