Oleic Acid sebagai Terapi Komplementer Kanker
DOI:
https://doi.org/10.29303/jku.v12i2.950Abstract
Abstract: Cancer is a global health problem that is responsible for one in six deaths worldwide. Over the last few decades, there were only a few cancer treatment options for patients, namely surgery, radiation therapy, and chemotherapy as a single treatment or in combination. This method is considered to have many shortcomings, so alternative therapy is needed. Several natural compounds are reported to have anti-cancer properties, one of which is Oleic Acid (OA). Some of the benefits of oleic acid are inhibiting cancer cell proliferation, inducing apoptosis and autophagy in cancer cells, and as an antitumor. Various types of cancer that significantly affect the content of oleic acid, namely, human lung carcinoma, Tongue Squamous Cell Carcinoma (TSCC), esophageal cancer, breast cancer, and lung adenocarcinoma. In general, the results of studies regarding the anti-inflammatory and
anti-cancer functions of omega-9 apart from oleic acid are quite scarce. Thus, further studies are needed to better understand the mechanism of omega-9, especially oleic acid, which can reduce cancer risk.
References
Atef, B., Ishak, R. A. H., Badawy, S. S., & Osman, R.
(2023). 10-Hydroxy Decanoic Acid-Based Vesicles
as a Novel Topical Delivery System: Would It Be a
Better Platform Than Conventional Oleic Acid
Ufasomes for Skin Cancer Treatment?
Pharmaceutics, 15(5).
https://doi.org/10.3390/pharmaceutics15051461
Blagosklonny, M. V. (2001). Cell Cycle Checkpoints and
Cancer. In Molecular Biology.
Carrillo, C., Cavia, M. del M., & Alonso-Torre, S. R.
(2012). Efecto antitumoral del ácido oleico;
mecanismos de acción; revisión científica.
Nutricion Hospitalaria, 27(6), 1860–1865.
https://doi.org/10.3305/nh.2012.27.6.6010
Debela, D. T., Muzazu, S. G. Y., Heraro, K. D., Ndalama,
M. T., Mesele, B. W., Haile, D. C., Kitui, S. K., &
Manyazewal, T. (2021). New approaches and
procedures for cancer treatment: Current
perspectives. SAGE Open Medicine, 9.
https://doi.org/10.1177/20503121211034366
Farag, M. A., & Gad, M. Z. (2022). Omega-9 fatty acids:
potential roles in inflammation and cancer
management. Journal of Genetic Engineering and
Biotechnology, 20(1).
https://doi.org/10.1186/s43141-022-00329-0
Garcia Martin, A., Fernandez Rodriguez, E. J., Sanchez
Gomez, C., & Rihuete Galve, M. I. (2022). Study on
the Socio-Economic Impact of Cancer Disease on
Cancer Patients and Their Relatives. Healthcare, 1–
https://doi.org/10.3390/healthcare10122370
Habermann, N., Schön, A., Lund, E. K., & Glei, M. (2010).
Fish fatty acids alter markers of apoptosis in
colorectal adenoma and adenocarcinoma cell lines
but fish consumption has no impact on apoptosisinduction ex vivo. Apoptosis, 15(5), 621–630.
https://doi.org/10.1007/s10495-010-0459-y
Jiang, L., Wang, W., He, Q., Wu, Y., Lu, Z., Sun, J., Liu,
Z., Shao, Y., & Wang, A. (2017). Oleic acid induces
apoptosis and autophagy in the treatment of
Tongue Squamous cell carcinomas. Scientific
Reports, 7(1), 1–11.
https://doi.org/10.1038/s41598-017-11842-5
Kementerian Kesehatan RI. (2022). Panduan
Pelaksanaan Hari Kanker Sedunia 2022.
Kementerian Kesehatan RI, 1–17.
https://promkes.kemkes.go.id/download/ftjl/fil
es90159BUKU PANDUAN HKS 2022 (3).pdf
Lee, S., & Na, K. (2020). Oleic acid conjugated polymeric
photosensitizer for metastatic cancer targeting in
photodynamic therapy. Biomaterials Research, 24(1),
–9. https://doi.org/10.1186/s40824-019-0177-7
Liotti, A., Cosimato, V., Mirra, P., Calì, G., Conza, D.,
Secondo, A., Luongo, G., Terracciano, D.,
Jurnal Kedokteran Unram June 2023, 12 (2), 222 – 227
(2)
Formisano, P., Beguinot, F., Insabato, L., &
Ulianich, L. (2018). Oleic acid promotes prostate
cancer malignant phenotype via the G proteincoupled receptor FFA1/GPR40. Journal of Cellular
Physiology, 233(9), 7367–7378.
https://doi.org/10.1002/jcp.26572
Moon, H. S., Batirel, S., & Mantzoros, C. S. (2014). Alpha
linolenic acid and oleic acid additively downregulate malignant potential and positively crossregulate AMPK/S6 axis in OE19 and OE33
esophageal cancer cells. Metabolism: Clinical and
Experimental, 63(11), 1447–1454.
https://doi.org/10.1016/j.metabol.2014.07.009
Mora, E., Emrizal, & Selpas, N. (2013). Isolasi dan
Karakterisasi Asam Oleat dari Kulit Buah Kelapa
Sawit (Elais guinensis Jacq.). Jurnal Penelitian
Farmasi Indonesia, 1(2), 47–51.
Nahla, E. S. E. S. O. (2013). Nutritional value of some
Egyptian sea cucumbers. African Journal of
Biotechnology, 12(35), 5466–5472.
https://doi.org/10.5897/ajb2013.13020
Niederhuber, J. E., Armitage, J. O., Doroshow, J. H.,
Kastan, M. B., & Tepper, J. E. (2016). Abeloff’s
Clinical Oncology (6th ed.). Elsevier.
Özyurt, G., Şimşek, A., Etyemez, M., & Polat, A. (2013).
Fatty acid composition and oxidative stability of
fish oil products in turkish retail market. Journal of
Aquatic Food Product Technology, 22(3), 322–329.
https://doi.org/10.1080/10498850.2011.644882
Piegari, M., Soria, E. A., Eynard, A. R., & Valentich, M.
A. (2017). Delay of Lung Adenocarcinoma (LAC-1)
Development in Mice by Dietary Oleic Acid.
Nutrition and Cancer, 69(7), 1069–1074.
https://doi.org/10.1080/01635581.2017.1359319
Pravst, I. (2014). Oleic acid and its potential health
effects. In Oleic Acid: Production, Uses and Potential
Health Effects (Issue August).
Pringgenies, D., Indrajati, R. M., & Djunaedi, A. (2020).
Study of Nutritional Contents of Sea Urchin Gonad
From Drini Beach, Gunung Kidul, Yogyakarta.
Jurnal Kelautan: Indonesian Journal of Marine Science
and Technology, 13(3), 219–227.
https://doi.org/10.21107/jk.v13i3.7808
Saini, A., Kumar, M., Bhatt, S., & Saini, V. (2020).
CANCER CAUSES AND TREATMENTS.
International Journal of Pharmaceutical Sciences and
Research, 11(7), 3121–3134.
https://doi.org/10.13040/IJPSR.0975-
11(7).3121-34.
Shahidi, F., & Zhong, Y. (2015). Measurement of
antioxidant activity. Journal of Functional Foods, 18,
–781. https://doi.org/10.1016/j.jff.2015.01.047
Tarin, D. (2022). Understanding Cancer The Molecular
Mechanisms, Biology, Pathology and Clinical
Implications of Malignant Neoplasia. In
Understanding Cancer. Springer.
https://doi.org/10.56021/9780801884177
Truong, D. H., Nguyen, D. H., Ta, N. T. A., Bui, A. V.,
Do, T. H., & Nguyen, H. C. (2019). Evaluation of
the use of different solvents for phytochemical
constituents, antioxidants, and in vitro antiinflammatory activities of severinia buxifolia.
Journal of Food Quality, 2019.
https://doi.org/10.1155/2019/8178294
World Health Organisation. (2020). Latest global cancer
data: Cancer burden rises to 19.3 million new cases
and 10.0 million cancer deaths in 2020. International
Agency for Research on Cancer, December, 13–15.
Yamagata, K., Uzu, E., Yoshigai, Y., Kato, C., & Tagami,
M. (2021). Oleic acid and oleoylethanolamide
decrease interferon-γ-induced expression of PD-L1
and induce apoptosis in human lung carcinoma
cells. European Journal of Pharmacology,
(November 2020), 174116.
https://doi.org/10.1016/j.ejphar.2021.174116
Zhang, Q. W., Lin, L. G., & Ye, W. C. (2018). Techniques
for extraction and isolation of natural products: A
comprehensive review. Chinese Medicine (United
Kingdom), 13(1), 1–26.
https://doi.org/10.1186/s13020-018-0177-x
Zhong, S., Liu, S., Chen, S., Liu, H., Zhou, S., Qin, X., &
Wang, W. (2015). Cytotoxicity and apoptosis
induction of bovine alpha-lactalbumin-oleic acid
complex in human breast cancer cells. Food Science
and Technology Research, 21(1), 103–110.
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