Tinjauan Pustaka: Pengaruh Vitamin C, Vitamin D, dan Zinc Terhadap COVID-19
DOI:
https://doi.org/10.29303/jku.v10i4.597Kata Kunci:
Vitamin C, zinc, Vitamin D, Covid-19Abstrak
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) adalah virus corona yang baru muncul, sangat menular, dan bersifat patogen. Hingga saat ini belum ada terapi definitif untuk infeksi SARS-CoV2 yang dikenal dengan COVID-19. Terapi suportif yang dapat dilakukan adalah pemberian suplementasi vitamin dan mineral dengan konsumsi vitamin C, vitamin D, dan Zinc. Beberapa penelitian menunjukkan pemberian vitamin C secara oral dan intravena dapat mengurangi peningkatan risiko komplikasi, mengurangi tingkat keparahan, mengatasi gejala maupun meningkatkan prognosis pasien dengan COVID-19.Vitamin D diketahui memiliki efek positif terhadap sistem imun tubuh dengan cara meredam proses inflamasi berlebihan. Zinc berpotensi mengurangi risiko infeksi SARS-CoV-2 dan memperpendek durasi dan tingkat keparahan penyakit.
Referensi
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15. Mittal, A., Manjunath, K., Ranjan, R. K., Kaushik, S., Kumar, S., & Verma, V. (2020). COVID-19 pandemic: Insights into structure, function, and hACE2 receptor recognition by SARS-CoV-2. PLoS pathogens, 16(8), e1008762. https://doi.org/10.1371/journal.ppat.1008762
16. Li, H., Liu, S. M., Yu, X. H., Tang, S. L., & Tang, C. K. (2020). Coronavirus disease 2019 (COVID-19): current status and future perspectives. International journal of antimicrobial agents, 55(5), 105951. https://doi.org/10.1016/j.ijantimicag.2020.105951
17. Pal, A., Squitti, R., Picozza, M., Pawar, A., Rongioletti, M., Dutta, A. K., Sahoo, S., Goswami, K., Sharma, P., & Prasad, R. (2021). Zinc and COVID-19: Basis of Current Clinical Trials. Biological trace element research, 199(8), 2882–2892. https://doi.org/10.1007/s12011-020-02437-9
18. Simonson W. (2020). Vitamin C and coronavirus. Geriatric nursing (New York, N.Y.), 41(3), 331–332. https://doi.org/10.1016/j.gerinurse.2020.05.002
19. Teshome, A., Adane, A., Girma, B., & Mekonnen, Z. A. (2021). The Impact of Vitamin D Level on COVID-19 Infection: Systematic Review and Meta-Analysis. Frontiers in public health, 9, 624559. https://doi.org/10.3389/fpubh.2021.624559
20. Wessels, I., Rolles, B., & Rink, L. (2020). The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis. Frontiers in immunology, 11, 1712. https://doi.org/10.3389/fimmu.2020.01712
21. Yisak, H., Ewunetei, A., Kefale, B., Mamuye, M., Teshome, F., Ambaw, B., & Yideg Yitbarek, G. (2021). Effects of Vitamin D on COVID-19 Infection and Prognosis: A Systematic Review. Risk management and healthcare policy, 14, 31–38. https://doi.org/10.2147/RMHP.S291584
22. Yuki, K., Fujiogi, M., & Koutsogiannaki, S. (2020). COVID-19 pathophysiology: A review. Clinical immunology (Orlando, Fla.), 215, 108427. https://doi.org/10.1016/j.clim.2020.108427
23. Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst Rev. (2013) 18:CD001364. doi: 10.1002/14651858.CD001364.pub4
24. Isaacs D, Flowers D, Clarke JR, Valman HB, MacNaughton MR. Epidemiology of coronavirus respiratory infections. Arch Dis Child. (1983) 58:500–3. doi: 10.1136/adc.58.7.500
25. Wang MX, Win SS, Pang J. Zinc supplementation reduces common cold duration among healthy adults: a systematic review of randomized controlled trials with micronutrients supplementation. Am J Trop Med Hyg. (2020). doi: 10.4269/ajtmh.19-0718
26. Kim WY, Jo EJ, Eom JS, Mok J, Kim MH, Kim KU, et al. hydrocortisone, and thiamine therapy for patients with severe pneumonia who were admitted to the intensive care unit: Propensity score-based analysis of a before-after cohort study. J Crit Care (2018) 47:211–8. doi: 10.1016/j.jcrc.2018.07.004
27. Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. Chest (2017) 151:1229–38. doi: 10.1016/j.chest.2016.11.036
28. Mason SA, Della Gatta PA, Snow RJ, Russell AP, Wadley GD. Ascorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: Findings of a randomized controlled study. Free Radic Biol Med (2016) 93:227–38. doi: 10.1016/j.freeradbiomed.2016.01.006
29. Karahan S, Katkat F. Impact of serum 25(OH) vitamin D level on mortality in patients with COVID-19 in Turkey. J Nutr Health Aging. (2020);5:1-8.
2. Annweiler, C., Hanotte, B., Grandin de l'Eprevier, C., Sabatier, J. M., Lafaie, L., & Célarier, T. (2020). Vitamin D and survival in COVID-19 patients: A quasi-experimental study. The Journal of steroid biochemistry and molecular biology, 204, 105771. https://doi.org/10.1016/j.jsbmb.2020.105771
3. Arentz, S., Hunter, J., Yang, G., Goldenberg, J., Beardsley, J., Myers, S. P., Mertz, D., & Leeder, S. (2020). Zinc for the prevention and treatment of SARS-CoV-2 and other acute viral respiratory infections: a rapid review. Advances in integrative medicine, 7(4), 252–260. https://doi.org/10.1016/j.aimed.2020.07.009
4. Bergman P. (2021). The link between vitamin D and COVID-19: distinguishing facts from fiction. Journal of internal medicine, 289(1), 131–133. https://doi.org/10.1111/joim.13158
5. Brenner H. (2021). Vitamin D Supplementation to Prevent COVID-19 Infections and Deaths-Accumulating Evidence from Epidemiological and Intervention Studies Calls for Immediate Action. Nutrients, 13(2), 411. https://doi.org/10.3390/nu13020411
6. Carr, A. C., & Maggini, S. (2017). Vitamin C and Immune Function. Nutrients, 9(11), 1211. https://doi.org/10.3390/nu9111211
7. Cerullo, G., Negro, M., Parimbelli, M., Pecoraro, M., Perna, S., Liguori, G., Rondanelli, M., Cena, H., & Giuseppe D. (2020). The Long History of Vitamin C: From Prevention of the Common Cold to Potential Aid in the Treatment of COVID-19. Italy: University of Pavia. Doi 10.3389/fimmu.2020.574029
8. Grant WB, Lahore H, McDonell SL, Baggerly CA, French CB, Aliano JL, et al. Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 2020;12(4):988.
9. Giuseppe, M., Giovanni, P., & Simone, N. (2020). Vitamin D and Covid-19: an update on evidence and potential therapeutic implications. doi: 10.1186/s12948-020-00139-0
10. Hoang, B. X., Shaw, G., Fang, W., & Han, B. (2020). Possible application of high-dose vitamin C in the prevention and therapy of coronavirus infection. Journal of global antimicrobial resistance, 23, 256–262. https://doi.org/10.1016/j.jgar.2020.09.025
11. Joachimiak M. P. (2021). Zinc against COVID-19? Symptom surveillance and deficiency risk groups. PLoS neglected tropical diseases, 15(1), e0008895. https://doi.org/10.1371/journal.pntd.0008895
12. Kumar, A., Kubota, Y., Chernov, M., & Kasuya, H. (2020). Potential role of zinc supplementation in prophylaxis and treatment of COVID-19. Medical hypotheses, 144, 109848. https://doi.org/10.1016/j.mehy.2020.109848
13. Li, H., Liu, S. M., Yu, X. H., Tang, S. L., & Tang, C. K. (2020). Coronavirus disease 2019 (COVID-19): current status and future perspectives. International journal of antimicrobial agents, 55(5), 105951. https://doi.org/10.1016/j.ijantimicag.2020.105951
14. Milani, G. P., Macchi, M., & Guz-Mark, A. (2021). Vitamin C in the Treatment of COVID-19. Nutrients, 13(4), 1172. https://doi.org/10.3390/nu13041172
15. Mittal, A., Manjunath, K., Ranjan, R. K., Kaushik, S., Kumar, S., & Verma, V. (2020). COVID-19 pandemic: Insights into structure, function, and hACE2 receptor recognition by SARS-CoV-2. PLoS pathogens, 16(8), e1008762. https://doi.org/10.1371/journal.ppat.1008762
16. Li, H., Liu, S. M., Yu, X. H., Tang, S. L., & Tang, C. K. (2020). Coronavirus disease 2019 (COVID-19): current status and future perspectives. International journal of antimicrobial agents, 55(5), 105951. https://doi.org/10.1016/j.ijantimicag.2020.105951
17. Pal, A., Squitti, R., Picozza, M., Pawar, A., Rongioletti, M., Dutta, A. K., Sahoo, S., Goswami, K., Sharma, P., & Prasad, R. (2021). Zinc and COVID-19: Basis of Current Clinical Trials. Biological trace element research, 199(8), 2882–2892. https://doi.org/10.1007/s12011-020-02437-9
18. Simonson W. (2020). Vitamin C and coronavirus. Geriatric nursing (New York, N.Y.), 41(3), 331–332. https://doi.org/10.1016/j.gerinurse.2020.05.002
19. Teshome, A., Adane, A., Girma, B., & Mekonnen, Z. A. (2021). The Impact of Vitamin D Level on COVID-19 Infection: Systematic Review and Meta-Analysis. Frontiers in public health, 9, 624559. https://doi.org/10.3389/fpubh.2021.624559
20. Wessels, I., Rolles, B., & Rink, L. (2020). The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis. Frontiers in immunology, 11, 1712. https://doi.org/10.3389/fimmu.2020.01712
21. Yisak, H., Ewunetei, A., Kefale, B., Mamuye, M., Teshome, F., Ambaw, B., & Yideg Yitbarek, G. (2021). Effects of Vitamin D on COVID-19 Infection and Prognosis: A Systematic Review. Risk management and healthcare policy, 14, 31–38. https://doi.org/10.2147/RMHP.S291584
22. Yuki, K., Fujiogi, M., & Koutsogiannaki, S. (2020). COVID-19 pathophysiology: A review. Clinical immunology (Orlando, Fla.), 215, 108427. https://doi.org/10.1016/j.clim.2020.108427
23. Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst Rev. (2013) 18:CD001364. doi: 10.1002/14651858.CD001364.pub4
24. Isaacs D, Flowers D, Clarke JR, Valman HB, MacNaughton MR. Epidemiology of coronavirus respiratory infections. Arch Dis Child. (1983) 58:500–3. doi: 10.1136/adc.58.7.500
25. Wang MX, Win SS, Pang J. Zinc supplementation reduces common cold duration among healthy adults: a systematic review of randomized controlled trials with micronutrients supplementation. Am J Trop Med Hyg. (2020). doi: 10.4269/ajtmh.19-0718
26. Kim WY, Jo EJ, Eom JS, Mok J, Kim MH, Kim KU, et al. hydrocortisone, and thiamine therapy for patients with severe pneumonia who were admitted to the intensive care unit: Propensity score-based analysis of a before-after cohort study. J Crit Care (2018) 47:211–8. doi: 10.1016/j.jcrc.2018.07.004
27. Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. Chest (2017) 151:1229–38. doi: 10.1016/j.chest.2016.11.036
28. Mason SA, Della Gatta PA, Snow RJ, Russell AP, Wadley GD. Ascorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: Findings of a randomized controlled study. Free Radic Biol Med (2016) 93:227–38. doi: 10.1016/j.freeradbiomed.2016.01.006
29. Karahan S, Katkat F. Impact of serum 25(OH) vitamin D level on mortality in patients with COVID-19 in Turkey. J Nutr Health Aging. (2020);5:1-8.
Unduhan
Diterbitkan
2022-01-22
Cara Mengutip
Eva Hikmatul Damayanti, & Budyono, C. (2022). Tinjauan Pustaka: Pengaruh Vitamin C, Vitamin D, dan Zinc Terhadap COVID-19. Baphomet University : Situs Slot Online Gacor Terbaik Hari Ini Server Thailand Gampang Maxwin 2024, 10(4), 694–702. https://doi.org/10.29303/jku.v10i4.597
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