Peran Neuroprotektif Cognitive Reserve Dalam Menghambat Progresivitas Gangguan Kognitif Terkait Diabetes Melitus Tipe 2
DOI:
https://doi.org/10.29303/jku.v9i4.432Kata Kunci:
diabetes melitus tipe 2, kontrol glikemik, resistensi insulin, cognitive reserve, aktivitas fungsionalAbstrak
Gangguan kognitif merupakan salah satu komplikasi penting dari diabetes melitus tipe 2. Gangguan kognitif terkait diabetes melitus tipe 2 tersebut memiliki spektrum yang cukup luas, mulai dari gangguan kognitif ringan sampai dengan demensia. Kerentanan penderita diabetes melitus tipe 2 untuk mengalami gangguan kognitif turut ditentukan oleh status cognitive reserve dari penderitanya tersebut. Cognitive reserve yang baik dari seorang penderita diabetes melitus tipe 2 akan memberikan proteksi penderita tersebut dari terjadinya gangguan kognitif. Komponen-komponen cognitive reserve, antara lain pendidikan, pekerjaan, hobi, aktivitas sosial dan fisik memberikan efek proteksi melalui mekanisme neural reserve dan neural compensation yang mampu menginduksi proses neurogenesis, produksi neurotropik, dan regulasi neurotransmiter. Pemahaman mengenai efek neuroprotektif dari komponen-komponen cognitive reserve sangat penting dalam menentukan strategi tatalaksana gangguan kognitif pada pasien diabetes melitus tipe 2, sedemikian rupa sehingga penderitanya masih mampu melakukan aktivitas fungsional sehari-hari dengan baik.
Referensi
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2. Umegaki H. Type 2 diabetes as a risk factor for cognitive impairment: current insights. Clin Interv Aging. 2014;9:1011–9.
3. Saedi E, Gheini MR, Faiz F, Arami MA. Diabetes mellitus and cognitive impairments. World J Diabetes. 2016;7(17):412–22.
4. Biessels GJ, Despa F. Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications. Nat Rev Endocrinol. 2018;14(10):591–604.
5. Li W, Sun L, Li G, Xiao S. Prevalence, Influence Factors and Cognitive Characteristics of Mild Cognitive Impairment in Type 2 Diabetes Mellitus. Front Aging Neurosci. 2019;11:180.
6. Teixeira MM, Passos VMA, Barreto SM, Schmidt MI, Duncan BB, Beleigoli AMR, et al. Association between diabetes and cognitive function at baseline in the Brazilian Longitudinal Study of Adult Health (ELSA- Brasil). Sci Rep. 2020;10:1596.
7. Xia S-S, Xia W-L, Huang J-J, Zou H-J, Tao J, Yang Y. The factors contributing to cognitive dysfunction in type 2 diabetic patients. Ann Transl Med. 2020;8(4):104.
8. Cheng S-T. Cognitive Reserve and the Prevention of Dementia: the Role of Physical and Cognitive Activities. Curr Psychiatry Rep. 2016;18:85. Available from: http://dx.doi.org/10.1007/s11920-016-0721-2
9. Darwish H, Farran N, Assaad S, Chaaya M. Cognitive Reserve Factors in a Developing Country: Education and Occupational Attainment Lower the Risk of Dementia in a Sample of Lebanese Older Adults. Front Aging Neurosci. 2018;10:277.
10. Pinto C, Tandel KY. Cognitive reserve: Concept , determinants , and promotion. J Geriatr Ment Heal. 2016;3:44–51.
11. Zhu X, Qiu C, Zeng Y, Li J. Leisure activities, education, and cognitive impairment in Chinese older adults: a population-based longitudinal study. Int P. 2017;29(5):727–39.
12. WHO. GLOBAL REPORT ON DIABETES. Geneva; 2016.
13. Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018;14:88–98. Available from: http://dx.doi.org/10.1038/nrendo.2017.151
14. Fan W. Epidemiology in diabetes mellitus and cardiovascular disease. Cardiovasc Endocrinol. 2017;6(1):8–16.
15. Verny C, Doucet J, Bauduceau B, Constans T, Mondon K, Le Floch JP. Prevalence of cognitive decline and associated factors in elderly type 2 diabetic patients at inclusion in the GERODIAB cohort. Eur Geriatr Med. 2015;6(1):36–40. Available from: http://dx.doi.org/10.1016/j.eurger.2014.10.006
16. Lavielle P, Talavera JO, Reynoso N, González M, Gomez-Diaz RA, Cruz M, et al. Prevalence of Cognitive Impairment in Recently Diagnosed Type 2 Diabetes Patients: Are Chronic Inflammatory Diseases Responsible for Cognitive Decline? PLoS One. 2015;10(10):e0141325.
17. Zilliox LA, Chadrasekaran K, Kwan JY, Russel JW. Diabetes and Cognitive Impairment. Curr Diab Rep. 2016;16(9):87. Available from: doi:10.1007/s11892-016-0775-x
18. Seto SW, Yang GY, Kiat H, Bensoussan A, Kwan YW, Chang D. Diabetes Mellitus, Cognitive Impairment, and Traditional Chinese Medicine. Int J Endocrinol. 2015;2015:810439.
19. Kim H-G. Cognitive dysfunctions in individuals with diabetes mellitus. Yeungnam Univ J Med. 2019;36(3):183–91. Available from: https://doi.org/10.12701/yujm.2019.00255
20. Verma N, Despa F. Contributing Factors to Diabetic Brain Injury and Cognitive Decline. Diabetes Metab J. 2019;43:560–7. Available from: https://doi.org/10.12701/yujm.2019.00255
21. Burda JE, Sofroniew M V. Reactive gliosis and the multicellular response to CNS damage and disease. Neuron. 2014;81(2):229–48.
22. Tang BL. Amyloid Precursor Protein (APP) and GABAergic Neurotransmission. Cells. 2019;8:550.
23. Stern Y. Cognitive Reserve: Implications for Assessment and Intervention. Folia Phoniatr Logop. 2013;65(2):49–54.
24. Steffener J, Stern Y. Exploring the neural basis of cognitive reserve in aging. Biochim Biophys Acta. 2012;1822(3):467–73. Available from: http://dx.doi.org/10.1016/j.bbadis.2011.09.012
25. Wang H-X, Xu W, Pei J-J. Leisure activities , cognition and dementia. BBA - Mol Basis Dis. 2012;1822:482–91. Available from: http://dx.doi.org/10.1016/j.bbadis.2011.09.002
26. Peña-González P, Mondragón-Maya A, Silva-Pereyra J, Roa-Rojas P. Cognitive Reserve and Executive Functions in Adults with Type 2 Diabetes. J Diabetes Res. 2020;2020:7941543.
27. Vivar C, Potter MC, Praag H Van. All About Running: Synaptic Plasticity, Growth Factors and Adult Hippocampal Neurogenesis. Curr Top Behav Neurosci. 2013;15:189–210.
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Diterbitkan
2021-01-11
Cara Mengutip
Harahap, H. S., & Indrayana, Y. . (2021). Peran Neuroprotektif Cognitive Reserve Dalam Menghambat Progresivitas Gangguan Kognitif Terkait Diabetes Melitus Tipe 2. Baphomet University : Situs Slot Online Gacor Terbaik Hari Ini Server Thailand Gampang Maxwin 2024, 9(4), 256–263. https://doi.org/10.29303/jku.v9i4.432
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