Gut-Brain Connection : The Role Of Gut Microbiome in Preventing Stroke
DOI:
https://doi.org/10.29303/jku.v11i1.536Kata Kunci:
Gut-Brain Connection, Gut-Brain Axis, Microbiota Usus, StrokeAbstrak
Stroke merupakan penyakit penyebab kematian terbanyak kedua didunia dan peringkat ketiga terbanyak sebagai penyebab kecacatan. Stroke tidak hanya berdampak pada bidang kesehatan, tetapi dapat mempengaruhi bidang sosial, fisik, dan psikologis karena penurunan kualitas hidup penderita dan bidang ekonomi karena memerlukan biaya yang besar dalam perawatannya. Hingga saat ini penanganan stroke masih terpusat dalam pengobatan dan rehabilitasi, diperlukan upaya promotif dan preventif dalam penanganan stroke. Beberapa studi menunjukkan bahwa terdapat hubungan antara mikrobiota usus dan sistem saraf yang disebut Gut-Brain Connection atau Gut-brain Axis (GBA). Mikrobiota usus memiliki peranan penting dalam GBA. Menjaga keseimbangan mikrobiota usus merupakan salah satu cara dalam mencegah terjadinya stroke, melalui komunikasi dua arah baik secara neuronal atau non-neuronal yang terjadi antara otak dan usus.
Referensi
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[2] W. Johnson, O. Onuma, M. Owolabi and S. Sachdev, "Stroke: a global response is needed," Bulletin of the World Health Organization, vol. 94, no. 9, pp. 633-708, 2016.
[3] Y. Turana, K. Kario and e. al, "Hypertension and stroke in Asia: A comprehensive review from HOPE Asia," The Journal of Clinical Hypertension, vol. 23, no. 3, pp. 513-521, 2020.
[4] Kementrian Kesehatan RI, "Pusdatin Kemenkes," 28 Oktober 2019. [Online]. Available: https://pusdatin.kemkes.go.id/download.php?file=download/pusdatin/infodatin/infodatin-stroke-dont-be-the-one.pdf. [Accessed 12 April 2021].
[5] A. K. Hasan, "STUDY KASUS GANGGUAN PERFUSI JARINGAN SEREBRAL DENGAN PENURUNAN KESADARAN PADA KLIEN STROKE HEMORAGIK SETELAH DIBERIKAN POSISI KEPALA ELEVASI 30º," Jurnal Ilmiah Multi Science Kesehatan Volume 9 NO 2, 2018.
[6] V. M. Adams RD, The Neurology of Aging. In Adams and Victor’s Principle Of Neurology, 9th Edition, USA:The McGraw: Hill Companies, 2009.
[7] A. K. Wijaya, "Patofisiologi Stroke Non-Hemoragik Akibat Trombus," Bagian SMF Ilmu Penyakit Saraf Fakultas Kedokteran universitas Udayana, 2013.
[8] T. d. W. Aninditha, Buku Ajar Neurologi, Jakarta: Departemen Neurologi FKUI, 2017.
[9] M. Carabotti, A. Scirocco, M. A. Maselli and C. Severi, "The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems," Ann Gastroenterol, 2015.
[10] M. Carabotti, A. Scirocco, M. A. Maselli and C. Severia, "The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems," Annals of Gastroenterology, vol. 28, no. 2, pp. 203-209, 2015.
[11] J. Appleton, "The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health," IMCJ, vol. 17, no. 2, pp. 28-32, 2018.
[12] P. David J. Durgan, P. Juneyoung Lee, M. P. Louise D. McCullough and P. Robert M. Bryan Jr, "Examining the Role of the Microbiota-Gut-Brain Axis in Stroke," ahajournals, vol. 50, no. 8, pp. 2270-2277, 2019.
[13] J. Appleton, "The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health," Integrative Medicine : a Clinician's Journal, vol. 17, no. 4, pp. 28-32, 2018.
[14] C. R. Martin, V. Osadchiy, A. Kalani and E. A. Mayer, "The Brain-Gut-Microbiome Axis," CMGH, vol. 6, no. 2, pp. 133-148, 2018.
[15] C. R. Martin, V. Osadchiy, A. Kalani and a. E. A. Mayer, "The Brain-Gut-Microbiome Axis," Cellular and Molecular Gastroenterohepatology, vol. 6, no. 2, pp. 133-148, 2018.
[16] Y. K. K. a. C. Shin, "The Microbiota-Gut-Brain Axis in Neuropsychiatric Disorders: Patho-physiological Mechanisms and Novel Treatments," Current Neuropharmacology, vol. 16, no. 5, pp. 559-573, 2018.
[17] B. Y. Q. Tan, P. R. Paliwal and a. V. K. Sharma, "Gut Microbiota and Stroke," Annals of Indian Academy of Neurology, vol. 23, no. 2, pp. 155-158, 2020.
[18] V. Singh, S. Roth, G. Llovera, R. Sadler, D. Garzetti, B. Stecher, M. Dichgans and a. A. Liesz, "Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke," The Journal of Neuroscience, vol. 36, no. 28, pp. 7428-7440, 2016.
[19] A. K. Arya and B. Hu, "Brain–gut axis after stroke," Brain Circulation, vol. 4, no. 4, pp. 165-173, 2018.
[20] C. Benakis, D. Brea, S. Caballero, G. Faraco, J. Moore, M. Murphy, G. Sita, G. Racchumi, L. Ling, E. G. Pamer, C. Iadecola and a. J. Anrather, "Commensal microbiota affects ischemic stroke outcome by regulating intestinal ??T cells," Nature Med, vol. 22, no. 5, pp. 516-523, 2016.
Unduhan
Diterbitkan
2022-03-30
Cara Mengutip
Baiq Annisa Pratiwi, Putri Atmaja, P. D. A., Qurrata’yuni Pratiwi, & Ilsa Hunaifi. (2022). Gut-Brain Connection : The Role Of Gut Microbiome in Preventing Stroke. Baphomet University : Situs Slot Online Gacor Terbaik Hari Ini Server Thailand Gampang Maxwin 2024, 11(1), 726–731. https://doi.org/10.29303/jku.v11i1.536
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