Korelasi Skor Mini Mental State Examination (MMSE) dan Montreal Cognitive Assessment Versi Indonesia (MoCA-Ina) Sebagai Instrumen Evaluasi Fungsi Kognitif pada Pasien Epilepsi di Kota Mataram
DOI:
https://doi.org/10.29303/jku.v10i1.470Kata Kunci:
Epilepsi, fungsi kognitif, MMSE, MoCA-InaAbstrak
Latar Belakang : Epilepsi merupakan penyakit neurologi dengan prevalensi tertinggi di dunia. Salah satu komplikasi penting dari epilepsi adalah penurunan fungsi kognitif. Penelitian ini bertujuan untuk menganalisis korelasi skor Mini-mental State Examination (MMSE) dan Montreal Cognitive Assessment Versi Indonesia (MoCA-Ina) pada pasien Epilepsi di kota Mataram.
Metode : Penelitian observasional dengan metode potong lintang ini melibatkan 56 subjek dengan epilepsi di dua rumah sakit rujukan utama di Mataram, Nusa Tenggara Barat. Dilakukan pengambilan data skor MMSE dan MoCA-Ina pada subjek tersebut. Disamping itu juga dilakukan pengambilan data yang meliputi usia, jenis kelamin, tingkat pendidikan, kontrol bangkitan, etiologi epilepsi, tipe bangkitan, obat antiepilepsi yang digunakan, dan status merokok dari subjek. Korelasi rerata skor MMSE dan MoCA-Ina dari subjek dianalisis secara statistik dengan uji korelasi Spearman.
Hasil : Hasil penelitian menunjukkan bahwa subjek penelitian ini memiliki rerata usia 32.9 tahun, jenis kelamin perempuan (55.4%), dan tingkat pendidikan rendah (62.5%). Terkait dengan karakteristik klinik, sebagian besar pasien tidak mengalami depresi (67%), memiliki kontrol bangkitan yang buruk (55.4%), etiologi idiopatik (66.9%), tipe bangkitan umum (71.4%), dan mendapatkan monoterapi (85.7%). Sebagian besar subjek adalah bukan perokok (76.8%). Hasil penelitian juga menunjukkan bahwa rerata skor MMSE dan MoCA-Ina dari subjek adalah 25.3 dan 21.3. Rerata skor MMSE memiliki korelasi kuat dengan rerata skor MoCA-Ina (r=0.766; p<0.001).
Kesimpulan : Rerata skor MMSE dan MoCA-Ina pasien epilepsi di Kota Mataram memiliki korelasi yang kuat. Dengan demikian, kedua instrumen tersebut dapat digunakan untuk evaluasi fungsi kogitif pada pasien epilepsi.
Referensi
2. World Health Organization, 2019. Epilepsy , available at : https://www.who.int/news-room/fact-sheets/detail/epilepsy
3. PERDOSSI, 2013. Available at : http://yankes.kemkes.go.id/read-epilepsi-4812.html
4. Harahap, H.S., Indrayana, Y., Amalia,E., 2017. Pola Pengobatan dan Fungsi Kognitif Pasien Epilepsi RSJ Mutiara Sukma, Jurnal Kedokteran Brawijaya, Vol 29, hh. 335-340.
5. Kerr, 2012. The Impact of Epilepsy on Patient’s Live, Acta Neurologica Scandinavica,Vol 126, hh 1 – 9.
6. Steiger dan Jokeit, 2017. Why Epilepsy Challanges Social Life, Elsevier, Seizure 44(2017), pp. 194-198.
7. Sheehan, Bart. 2012. Assessment scales in dementia, Therapeutic Advance Neurological Disorders, Vol 5, hh. 349-358.
8. Prasetyo, Lumempouw, Ramli dan Herquanto, 2011. NILAI NORMAL MONTREAL
COGNITIVE ASSESSMENT VERSI INDONESIA (MOCA-INA), NEURONA,
Vol 29 No. 1.
9. Biundo, R., Weis, L., Fiorenzato, E., Antonini, A., 2017. Cognitive Function in Parkinson’s Disease : is it feasible ?, Archieves of Clinical Neuropsychology, Vol 32, hh. 840- 860.
10. Trzepacz, Hochstetler, Wang, Walker, dan Saykin,2015. Relationship between the Montreal Cognitive Assessment and Mini-mental State Examination forassessment of mild cognitive impairment in older adults, BMC Geriart, Vol 15,hh. 107
11. Rambe dan Fitri, 2017. Correlation between the Montreal Cognitive AssessmentIndonesian Version (MoCA-Ina) and the Mini-Mental State Examination(MMSE) in Elderly, Open Access Macedonian Journal of Medical Sciences, Vol5, hh. 915-919.
12. Carnero-Pardo, 2014. Should the Mini-Mental State Examination be retired?,Neurologia, Vol 29, hh.473-481.
13. Lestari,S., Mistivani, I., Rumende, C.M., Kusumaningsih, W., 2017Comparison between mini mental state examination (MMSE) and Montreal cognitive assessment Indonesian version (MoCA-Ina) as an early detection of cognitive impairments in post-stroke patients
14. Lessig, Nie, D., Xu, R., Corey-Bloom, J., 2012. Changes on brief cognitive instruments overtime in Parkinson's disease, Wiley Movement Disorders, Vol 27, hh. 1125-8
15. Hu, Szewczyk-Królikowski, Tomlinson, P., Nithi, K., Rolinski, M., Murray, C., Talbot, K.,Ebmeier, Mackay, Ben-Shlomo, 2014. Predictors of cognitive impairment in an early stage Parkinson’s disease cohort, Wiley Movement Disorders, Vol 29, hh. 351-359
16. Kim, Sunwoo, Sohn, Lee, Hong, 2016. The MMSE and MoCA for Screening CognitiveImpairment in Less Educated Patients with Parkinson’s Disease, Journal of Movement Disorders, Vol 9, hh. 152-159
17. Folstein, F., Folstein, E., dan McHugh, 1975. “Mini-mental state”: A practical method forgrading the cognitive state of patients for the clinician, Elsevier, Vol 12, hh. 189-198
18. Nasreddine, Z.S., Philips, N.A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I.,Cummings, J.L., Chertkow, H.,2005. The Montreal Cognitive Assessment,MoCA:a brief screening tool for mild cognitive impairment, Journal ofAmerican Geriatrics Society, Vol 53, hh. 695-9
19. Fisekovic, Memic, dan Pasalic, 2012. CORRELATION BETWEEN MOCA ANDMMSE FOR THE ASSESSMENT OF COGNITION IN SCHIZOPHRENIA, Acta Informatica Medica, Vol 20, hh. 186-189
20. Zhao, Kang, You, Rastogi, Venkatesh, dan Chandra, 2014. Neuropsychological deficits intemporal lobe epilepsy: A comprehensive review, Annals of Indian Academy of Neurology, Vol 17, hh. 374-382
21. Hermann, B., Seidenberg, M., 2007. Epilepsy and Cognition, Epilepsy Curr, Vol 7, hh. 1-6
22. Upadhayay, dan Guragain, 2014. Comparison of cognitive functions between male and female medical students: a pilot study, Journal of Clinical and Diagnostic Research, Vol 8, hh. 12-15
23. Thomann, A., Goettel, N., Monsch, R.J., Berres, M., Jahn, T., Steiner, Monsch, A.U., 2018. TheMontreal Cognitive Assessment: Normative Data from a German-Speaking Cohort and Comparison with International Normative Samples, Journal of Alzheimer’s Disease, Vol 64, hh. 643-655
24. Loughman, A., Seneviratne, U., Bowden, S.C., D’Souza, W.J., 2016. Epilepsy Beyond Seizure : Predicting Enduring Cognitive Dysfungction in Genetic General Epilepsy, Epilepsy & Behavior, Vol 62, hh. 297-303
25. Sokka, A., Olsen, P., Kirjavainen, J., Harju, M., Keski-Nisula, L., Raisanen, S., Heinonen, S., Kalviainen, R., 2017. Etiology, syndrome diagnosis, and cognition in childhood?onset epilepsy: A population?based study, Epilepsia Open, Vol 2, hh. 76-83
26. Poudel, P., Chitlangia, M., Pokharel, R., 2016. Predictors of Poor Seizure Control in Children Managed at a Tertiary Care Hospital of Eastern Nepal, Iranian Journal of Child Neurology, Vol 10, hh. 48-56
27. Witt, dan Helmstaedter, 2012. Monitoring the cognitive effects of antiepilepticpharmacotherapy — approaching the individual patient, Elsevier, Vol 26, hh. 450-456
28. Natham, Arunachalam, dan Amirthalingam 2018. Comparison of Montreal Cognitive Assessment (MOCA) with Mini Mental State Examination (MMSE) on association between homocysteine and cognitive status in epilepsy patients with phenytoin monotherapy, Asia Pasific Journal of Councelling and Psychotherapy, Vol 9, hh 160 - 170
29. Elkana, O., Tal, N., Oren, N., 2019. Is the Cutoff of the MoCA too High? Longitudinal Data From Highly Educated Older Adults, Journal of Geriatric Psychiatry and Neurology, Vol 33, hh. 155-160
30. Harahap, H.S., Rizki, M., Nurfadia, M.F, Nabiela, A.S., Sari, I.P., 2020, Characteristics of Cognitive Status of Epilepsy Patients Treated WithMonotherapy of First-Generation Antiepileptic Drugs, Malaysian Journal ofPublic Health, Vol 20, hh. 11-18.
31. Milani, S.A., Marsiske, M., Cottler, L.B., Chen, C., Striley, C.W., 2018. Optimal cutoffs for the Montreal Cognitive Assessment vary by race and ethnicity, Alzheimers & Dementia Amsterdam, Vol 3, hh. 773-781
32. Kang, J.M., Cho, Y-S., Park, S., Lee, B.H., Sohn, B.K., Choi, C.H., Choi, J-S., Jeong, H.Y., Cho, S-J., Lee, J-H., Lee, J-Y., 2018. Montreal cognitive assessment reflects cognitive reserve, BMC Geriatrics, Vol 18, hh. 261
33. Phabphal, dan Kanjanasatien, 2011Montreal Cognitive Assessment in cryptogenic epilepsy patients with normal Mini-Mental State Examination scores, Epileptic Discord, Vol 13. hh. 375-381
